Arati A. Inamdar

Type II interferon-driven crosstalk between effector memory CART and myeloid cells is associated with CART19 resistance in relapsed refractory large B-cell lymphomas

Alice Wang, Luca Paruzzo, Martina Bonomi, Chia-Hui Chen et autres

Abstract Background: CD19-directed CART cell (CART19) therapy is standard of care for relapsed/refractory large B-cell lymphomas (r/r LBCL), but only one-third of patients (pts) maintain remission beyond 5 years. Mechanisms of resistance to CART range from antigen-negative escape to CART cell dysfunction. …

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Evaluating Non-Invasive Methods for Collateral Circulation Assessment in Radial Forearm Free Flap Surgery

Arati A. Inamdar

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CD5 deletion enhances the antitumor activity of adoptive T cell therapies

Ruchi P. Patel, Guido Ghilardi, Yunlin Zhang, Yi‐Hao Chiang et autres

Most patients treated with US Food and Drug Administration (FDA)-approved chimeric antigen receptor (CAR) T cells eventually experience disease progression. Furthermore, CAR T cells have not been curative against solid cancers and several hematological malignancies such as T cell lymphomas, which have …

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Hematological entities with plasmacytic differentiation: a case report

Arati A. Inamdar, Siddharth Bhattacharyya

INTRODUCTION: Plasmacytoma, a localized tumor of monoclonal plasma cells without any clinical, radiological or physical evidence of plasma cell neoplasm (PCN), is a rare entity that accounts for 1% of PCN. Immunoglobulin M (IgM) extramedullary plasmacytoma of mediastinal region has never been …

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DLBCL-associated NOTCH2 mutations escape ubiquitin-dependent degradation and promote chemoresistance

Nan Zhou, Jaewoo Choi, Grant P. Grothusen, Bang‐Jin Kim et autres

Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma. Up to 40% of patients with DLBCL display refractory disease or relapse after standard chemotherapy treatment (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone [R-CHOP]), leading to significant morbidity and mortality. …

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A Rare Case of a Translocation-Associated Perivascular Epithelioid Cell Neoplasm (PEComa)

K.L. Pereira, Arati A. Inamdar, Aditi Zaveri, Jonathan E. Teitelbaum et autres

A perivascular epithelioid cell tumor (PEComa) is a rare mesenchymal neoplasm composed of perivascular epithelioid cells with distinctive histologic, immunohistochemical, and genetic features. PEComas arising from various anatomical sites have been reported, but gastrointestinal PEComas are extremely rare entities. Here, we discuss …

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An Aggressive Presentation of Mantle Cell Lymphoma With Unique Molecular Features

Arati A. Inamdar, Abraham Loo, Nagy Mikhail, Patrick Lee

Mantle cell lymphoma (MCL) is an aggressive non-Hodgkin lymphoma (NHL) with a dismal prognosis. The pathogenesis of MCL is complex and involves molecular alterations in various genes and pathways including the regulatory elements of the cell cycle machinery and senescence, DNA damage …

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Biomarkers and novel therapeutic approaches for diffuse large B-cell lymphoma in the era of precision medicine

Niraj Lodhi, Moe Tun, Poonam Nagpal, Arati A. Inamdar et autres

// Niraj Lodhi 1 , 2 , * , Moe Tun 2 , * , Poonam Nagpal 2 , 3 , Arati A. Inamdar 2 , Nehad M. Ayoub 4 , Noor Siyam 2 , Lucia Oton-Gonzalez 5 , Angela Gerona 2 …

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715. A 79 year old Female with Bloody Diarrhea and Hypovolemic Shock: Keep the Differential Diagnosis Open

Sindhura Inkollu, Sindhuja Korem, Sukrut Dwivedi, Ramy Osman et autres

Abstract Background Schistosomiasis is considered one of the neglected tropical diseases which is rarely seen in USA. We are reporting herein a case of intestinal schistosomiasis presented as bloody diarrhea and hypovolemic shock at Monmouth Medical Center, New Jersey. Methods: Case Report …

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Fungal Volatile Organic Compounds: More Than Just a Funky Smell?

Arati A. Inamdar, Shannon U. Morath, Joan W. Bennett

Many volatile organic compounds (VOCs) associated with industry cause adverse health effects, but less is known about the physiological effects of biologically produced volatiles. This review focuses on the VOCs emitted by fungi, which often have characteristic moldy or "mushroomy" odors. One …

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Secondary Plasma Cell Leukemia in a Recurrent Multiple Myeloma: Rare Case Scenario

Arati A. Inamdar, Abraham Loo, Nagy Mikhail, Patrick Lee

Plasma cell leukemia (PCL) is an aggressive hematological condition characterized by the presence of plasma cells in the peripheral smear. It presents as de novo or may arise from multiple myeloma (MM), and hence is diagnosed as primary or secondary PCL, respectively. …

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Gender-Discordant Monochorionic-Diamniotic Twins Both With 45,X/46,X, Idic(Y) Mosaicism and a Novel Deletion Within the TBC1D5 Gene

Arati A. Inamdar, Michael P. Diamond, Wendy Shertz

The occurrence of monochorionic diamniotic twins with sex discordance is a very rare phenomenon. We present a case of spontaneously conceived gender-discordant monochorionic diamniotic twins born to a 23-year-old female, both twins demonstrating similar blood karyotype 45,X/46,X, idic(Y) and a novel 99 …

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