Luisa Sophie Rajcsanyi

Benign form of monogenic obesity conferred by the melanocortin 4 receptor

Anke Hinney, Triinu Peters, Luisa Sophie Rajcsanyi

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Redesigning medicine: integrating sex and gender for better health outcomes

Luisa Sophie Rajcsanyi, Maren A. Jochimsen, Andrea Kindler‐Röhrborn, Anke Hinney

Both the biological sex and the socio-cultural gender play a central role in medical care, influencing diagnosis, disease progression, and treatment decisions. Despite well-established and substantial differences between men and women, sex-specific differentiation in guidelines, and dosing protocols remain limited. This gap …

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Distinct liver sections exhibit sex-specific gene expression patterns in Lewis rats

Luisa Sophie Rajcsanyi, Simge Oral, Julia Borgardt, Florian W. R. Vondran et autres

Abstract Sex-specific differences in liver gene expression have previously been reported in humans and rodents. Clinically, female-to-male liver transplants are known to be associated with adverse post-transplantation outcomes. However, the underlying molecular mechanisms remain largely unknown. Sex-specific gene expression differences may be …

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Genetische Varianten im GLP1-R-Gen und ihre geschlechtsspezifische Bedeutung bei Adipositas

Luisa Sophie Rajcsanyi, J. Alexander Schmidt, Alex B. Novikoff, Carol Coupland et autres

Die Wirksamkeit von Inkretin-basierten Therapien für Adipositas wird möglicherweise durch genetische Varianten beeinflusst. Daher wurden umfassende genetische und funktionelle Analysen der Gene GIP, GIP-R, GCG, GCG-R und GLP1-R in diversen Kollektiven von Patient*innen mit schwerer Adipositas durchgeführt.Basierend auf publizierten Daten einer genomweiten …

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Relevanz von Geschlecht und Gender für Adipositas und Essstörungen

Anke Hinney, Luisa Sophie Rajcsanyi

Jährlich ist in Deutschland mehr als ein Viertel der erwachsenen Bevölkerung von einer psychischen Erkrankung betroffen. Weniger als 20 Prozent davon suchen sich professionelle Hilfe. Dabei unterscheiden sich Männer und Frauen sowohl in ihrem Erleben und Verhalten als auch in der Art …

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No indications of weight gain associated DNA methylation changes in patients with anorexia nervosa

Luisa Sophie Rajcsanyi, Miriam Kesselmeier, Christopher Schröder, Carolin Schmelting et autres

Abstract Anorexia nervosa (AN) is a mental disorder marked by a significantly low body weight. Differentially methylated CpG sites have been reported to be involved in body weight regulation. Methylation pattern may change during considerable weight gain by in-patient treatment. Consequently, we …

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Sex-specific survival in advanced metastatic melanoma – a DeCOG study on 2032 patients of the multicenter prospective skin cancer registry ADOREG

Anna‐Sophia Leven, Triinu Peters, Luisa Sophie Rajcsanyi, Michael Weichenthal et autres

BACKGROUND: Females and males differ in their innate and acquired immune responses. Thus, it is hypothesized that the efficacy of anti-tumor immunotherapies may differ by sex. This study aimed to investigate sex-specific survival differences upon different therapy types in metastatic melanoma. PATIENTS …

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Morning clock gene expression in young adults of early and late chronotypes

Bettina Krueger, Luisa Sophie Rajcsanyi, Katharina Hundertmark, Bianca Stutz et autres

Abstract Variations in circadian rhythm-related genes influence the individual chronotype. Here, we hypothesize that the peak of clock gene expression at 7 a.m. differs between young adults with a late chronotype and young adults with an early chronotype. Participants of the Chronotype …

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Presence of brain metastasis differentially impacts long-term survival after first-line therapy in melanoma depending on BRAF mutation status

Jan‐Malte Placke, Luisa Sophie Rajcsanyi, Rudolf Herbst, Patrick Terheyden et autres

Background: Modern therapeutic strategies have significantly improved the prognosis of advanced melanoma patients. Predictive factors of therapy response include serum LDH; however, predictive markers for long-term survival are currently largely lacking. Patients and methods: Patients diagnosed with stage IV melanoma (AJCCv8) of …

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Sex-Specific Survival in Advanced Metastatic Melanoma – a Decog Study on 2032 Patients of the Multicenter Prospective Skin Cancer Registry Adoreg

Anna‐Sophia Leven, Triinu Peters, Luisa Sophie Rajcsanyi, Michael Weichenthal et autres

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Circular RNAs in Metabolic Diseases

Luisa Sophie Rajcsanyi, Triinu Peters, Anke Hinney

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Medicine for everyone : why sex and gender can make a difference

Luisa Sophie Rajcsanyi, Anke Hinney