Lídia Mateo

Author Correction: The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2

Selim Chaib, José A López-Domínguez, Marta Lalinde-Gutiérrez, Neus Prats et autres

In the version of this article initially published, the representative images for the control and 5 μM palbociblib treatments of SK-MEL-103 cells in Fig. 1a corresponded to control and 1 μM palbociclib-treated cells that we had previously discussed in another article (Llanos, …

us, es, gb (code pays fourni par la source)

Posttranscriptional reprogramming controls MASLD progression through chronic ER stress adaptation

Eulàlia Belloc, Vittorio Calderone, Salvador Naranjo-Suarez, Lídia Mateo et autres

Metabolic dysfunction-associated steatohepatitis (MASH) and its progression to hepatocellular carcinoma remain major clinical challenges. Chronic endoplasmic reticulum (ER) stress, induced by sustained high-fat diet (HFD) intake, promotes hepatic inflammation, lipid accumulation, and hepatocellular dysfunction during MASH pathogenesis. While transcriptional responses are well …

es, de (code pays fourni par la source)

TGF-β builds a dual immune barrier in colorectal cancer by impairing T cell recruitment and instructing immunosuppressive SPP1+ macrophages

Ana Henriques, Maria Salvany-Celades, Paula Nieto, Sergio Palomo‐Ponce et autres

es, nl (code pays fourni par la source)

Post transcriptional control restrains the IL17–GCSF axis and limits neutrophil-driven breast cancer metastasis

Raúl Méndez, Belén Guillén Tirado, Judit Martín, Marcos Fernández Alfara et autres

es (code pays fourni par la source)

Systematic study of hybrid triplex topology and stability suggests a general triplex-mediated regulatory mechanism

Vito Genna, Guillem Portella, Alba Sala, Montserrat Terrazas et autres

By combining in silico, biophysical, and in vitro experiments, we decipher the topology, physical, and potential biological properties of hybrid-parallel nucleic acids triplexes, an elusive structure at the basis of life. We found that hybrid triplex topology follows a stability order: r(Py)-d(Pu)·r(Py) …

es, gb (code pays fourni par la source)

Systematic study of hybrid triplex topology and stability suggests a general triplex-mediated regulatory mechanism

Vito Genna, Guillem Portella, Alba Sala, Montserrat Terrazas et autres

ABSTRACT By combining in-silico , biophysical and in-cellulo experiments, we decipher the topology, physical and potential biological properties of hybrid-parallel nucleic acids triplexes; an elusive structure at the basis of life. We found that hybrid triplex topology follows a stability order: r(Py)-d(Pu)·r(Py)> …

es (code pays fourni par la source)

The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2

Selim Chaib, José A López-Domínguez, Marta Lalinde-Gutiérrez, Neus Prats et autres

Chemotherapy often generates intratumoral senescent cancer cells that strongly modify the tumor microenvironment, favoring immunosuppression and tumor growth. We discovered, through an unbiased proteomics screen, that the immune checkpoint inhibitor programmed cell death 1 ligand 2 (PD-L2) is highly upregulated upon induction …

us, es, gb (code pays fourni par la source)

Abstract C040: Investigating oncogene-inflammation cooperativity in pancreatic cancer

Katharina Woess, Sandra Blázquez Araguás, Andrea Diéguez, Lídia Mateo et autres

Abstract Pancreatic ductal adenocarcinoma (PDAC) is generally diagnosed at advanced late stages when current treatments are usually ineffective. It is initiated from a poorly understood interplay between genetic mutations (mutant KRAS) and inflammatory insults that cooperatively remodel the pancreatic epithelium and its …

es (code pays fourni par la source)

Iron accumulation drives fibrosis, senescence and the senescence-associated secretory phenotype

Máté Maus, Vanessa López-Polo, Lídia Mateo, Miguel Lafarga et autres

Fibrogenesis is part of a normal protective response to tissue injury that can become irreversible and progressive, leading to fatal diseases. Senescent cells are a main driver of fibrotic diseases through their secretome, known as senescence-associated secretory phenotype (SASP). Here, we report …

es, de, gb (code pays fourni par la source)

Metastatic recurrence in colorectal cancer arises from residual EMP1+ cells

Adrià Cañellas‐Socias, Carme Cortina, Xavier Hernando‐Momblona, Sergio Palomo‐Ponce et autres

es, gb, be, nl (code pays fourni par la source)

The efficacy of chemotherapy is limited by intratumoural senescent cells that persist through the upregulation of PD-L2

Selim Chaib, José A López-Domínguez, Marta Lalinde-Gutiérrez, Neus Prats et autres

Abstract Anti-cancer therapies often result in a subset of surviving cancer cells that undergo therapy-induced senescence (TIS). Senescent cancer cells strongly modify the intratumoural microenvironment favoring immunosuppression and, thereby, tumour growth. An emerging strategy to optimise current therapies is to combine them …

us, es, gb (code pays fourni par la source)

Mex3a marks drug-tolerant persister colorectal cancer cells that mediate relapse after chemotherapy

Adrián Álvarez-Varela, Laura Novellasdemunt, Francisco M. Barriga, Xavier Hernando‐Momblona et autres

es, us, de, it, nl, be (code pays fourni par la source)