Jaana Haka

Subcutaneous Allergen Immunotherapy With Thermosensitive Hydrogel and Recombinant Birch Pollen Allergen Variant, a Randomised Controlled Trial

Anna Nilson, Patricia Couroux, Jaana Haka, Silja Halme et autres

ABSTRACT Background This paper reports a Phase 1, randomised, placebo‐controlled, dose‐escalation trial (NCT06037148) with DM‐101PX that contains a recombinant hypoallergenic Bet v 1 variant formulated with thermosensitive hydrogel. The objectives of the study included assessment of treatment‐related adverse events and the number …

fi, nl, gb (code pays fourni par la source)

Genetically engineered allergens formulated with thermosensitive hydrogel enable safe and fast up-dosing in allergen immunotherapy and induce a strong protective immune response

Juha Rouvinen, Jaana Haka, Silja Halme, Pekka Mattila et autres

Development of hypoallergenic variants of the major horse allergen Equ c 1 for immunotherapy by rational structure based engineering

Jaana Haka, Merja H. Niemi, Pekka Mattila, Janne Jänis et autres

The use of recombinant allergens is a promising approach in allergen-specific immunotherapy (AIT). Considerable limitation, however, has been the ability of recombinant allergens to activate effector cells leading to allergic reactions. Recombinant hypoallergens with preserved protein folding and capacity to induce protective …

fi (code pays fourni par la source)

6th International Symposium on Molecular Allergology (ISMA)

Christiane Hilger, Kyra Swiontek, Jörg Fischer, François Hentges et autres

Background: Delayed food anaphylaxis upon consumption of red meat is attributed to specific IgE-antibodies directed to galactose-α-1,3-galactose (α-Gal).Anaphylactic reactions may occur after ingestion of meat from different mammals, mainly beef and pork, but reactions to lamb, rabbit or horse have also been …

lu, de, es, at, se, fr, br, be, it, pt (code pays fourni par la source)

Isolation of Mal d 1 and Api g 1 - specific recombinant antibodies from mouse IgG Fab fragment libraries – Mal d 1-specific antibody exhibits cross-reactivity against Bet v 1

Jaana Haka, Merja H. Niemi, Kristiina Iljin, Vanga Siva Reddy et autres

BACKGROUND: Around 3-5% of the population suffer from IgE-mediated food allergies in Western countries and the number of food-allergenic people is increasing. Individuals with certain pollen allergies may also suffer from a sensitisation to proteins in the food products. As an example …

fi, in (code pays fourni par la source)

Development of recombinant antibodies for reliable and sensitive food allergen detection

Jaana Haka, Merja H. Niemi, Kristiina Iljin, Vanga Siva Reddy et autres

Around 4 % of the population suffer from IgE-mediated food allergies in Western countries and the number of food-allergenic people is increasing. Individuals with certain pollen allergies may also suffer from a sensitisation to proteins in the foods. As an example a …

fi, in (code pays fourni par la source)