Zhengzhao Liu

Retraction Note: Aged bone matrix-derived extracellular vesicles as a messenger for calcification paradox

Zhen‐Xing Wang, Zhong‐Wei Luo, Fu‐Xing‐Zi Li, Jia Cao et autres

The Authors have retracted this Article following the identification of multiple irregularities in the figures and data, including but not limited to, partial duplication of the field of view between Figs. 3j and 7f duplicated quantitative values in several histology-related quantitative panels …

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BMSC-targeting aptamer conjugation enhances bone delivery of a rice bran peptide to mitigate osteoporosis via eIF3L

Hao Yin, Tengfei Wan, Shan‐Shan Rao, Ze-Hui He et autres

Osteoporosis is frequently accompanied by a shift in the fate of bone marrow mesenchymal stromal cells (BMSCs) from osteogenesis toward adipogenesis, contributing to bone-fat imbalance and fragility fractures. Here, we evaluated a naturally occurring eight-amino acid rice bran-derived peptide, RBAP (KHNRGDEF), together …

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A prospective study to compare the efficacy and safety of glucocorticoid-free maintenance therapy versus low-dose glucocorticoid maintenance therapy for lupus nephritis—a pilot, single-center, randomized controlled study

Yuxin Rong, Jingjing Wang, Di Wu, Xinyue Wang et autres

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Long-term outcome and clinicopathological characteristics of propylthiouracil-induced ANCA-associated glomerulonephritis: a case-control study

Di Wu, Ruifeng Zhang, Xinyue Wang, Zhengzhao Liu et autres

OBJECTIVES: This retrospective study aims to determine the clinical and histological features and outcomes of propylthiouracil (PTU)-induced anti-neutrophil cytoplasmic antibody (ANCA) associated glomerulonephritis with primary ANCA-associated glomerulonephritis (AAGN). METHODS: Twenty-five patients diagnosed with PTU-induced AAGN and 379 patients with primary AAGN, who …

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Heterogeneous ageing of brain networks across the Alzheimer’s disease continuum

Yanxi Huo, Weijie Huang, Zhengzhao Liu, Tianyu Bai et autres

Abstract Accelerated brain ageing has been implicated in Alzheimer’s disease (AD), which is shaped by genetic risk, molecular pathology, and disease processes. However, the spatial heterogeneity of brain ageing patterns across different functional networks along the AD continuum remained largely unexplored. In …

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Fasting activates optineurin-mediated mitophagy in chondrocytes to protect against osteoarthritis

Minna Zhang, Ran Duan, Gui-Hong Chen, Meijun Chen et autres

Mitochondrial homeostasis plays a crucial role in the pathogenesis of osteoarthritis (OA), a chronic musculoskeletal disorder characterized by articular cartilage degeneration and chondrocyte apoptosis. However, molecular mechanisms underlying the association between mitophagy and OA remain unclear. Here, we aimed to investigate the …

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Actinin-1 binds to the C-terminus of A2B adenosine receptor (A2BAR) and enhances A2BAR cell-surface expression.

Zhengzhao Liu, Pingbo Huang, Xiaojie Yu, Wenbao Hu et autres

A2BAR (A2B adenosine receptor) has been implicated in several physiological conditions, such as allergic or inflammatory disorders, vasodilation, cell growth and epithelial electrolyte secretion. For mediating the protein-protein interactions of A2BAR, the receptor's C-terminus is recognized to be crucial. In the present …

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Transplantation of olfactory mucosa mesenchymal stromal cells repairs spinal cord injury by inducing microglial polarization

Xin Wang, Chun‐Gu Hong, Ran Duan, Zhi‐Lin Pang et autres

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Young osteocyte-derived extracellular vesicles facilitate osteogenesis by transferring tropomyosin-1

Zhen‐Xing Wang, Xiao Lin, Jia Cao, Yi-Wei Liu et autres

BACKGROUND: Bone marrow mesenchymal stem cells (BMSCs) can undergo inadequate osteogenesis or excessive adipogenesis as they age due to changes in the bone microenvironment, ultimately resulting in decreased bone density and elevated risk of fractures in senile osteoporosis. This study aims to …

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A Variable Wingspan Scroll Telescopic Wing for Multimodal Underwater Vehicles

Xiaoyan Zhao, Hui Zhi, Xinyu Fei, Xiaoya Qin et autres

This paper presents the design of a variable wingspan scroll telescopic wing for multimodal underwater vehicles, enabling the vehicles to adjust their wingspans as needed for optimal maneuverability. Detailed descriptions of the mechanical structure, geometric relationships, and force analysis of the scroll …

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Olfactory mucosa mesenchymal stem cells alleviate pulmonary fibrosis via the immunomodulation and reduction of inflammation

Ran Duan, Chun‐Gu Hong, Xin Wang, Ming Lu et autres

BACKGROUND: Pulmonary fibrosis (PF) is a progressive fibrosing interstitial pneumonia that leads to respiratory failure and other complications, which is ultimately fatal. Mesenchymal stem cells (MSCs) transplant is a promising strategy to solve this problem, while the procurement of MSCs from the …

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Reassessing endothelial-to-mesenchymal transition in mouse bone marrow: insights from lineage tracing models

Jia Cao, Ling Jin, Ziqi Yan, Xiaokai Wang et autres

Abstract Endothelial cells (ECs) and bone marrow stromal cells (BMSCs) play crucial roles in supporting hematopoiesis and hematopoietic regeneration. However, whether ECs are a source of BMSCs remains unclear. Here, we evaluate the contribution of endothelial-to-mesenchymal transition to BMSC generation in postnatal …

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