Xia Lei

STING Aggravates Ferroptosis in Septic Acute Kidney Injury by Promoting Ubiquitin–Proteasome–Dependent Degradation of FSP1

Xia Lei, Haixia Chai, Yunlai Zhao, Jingwen Sun et autres

Sepsis-associated acute kidney injury (SA-AKI) is a common and life-threatening complication of sepsis. Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, plays an important role in the pathogenesis of SA-AKI. However, the role of STING in regulating ferroptosis …

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A sex‐specific “hormone–bone–brain” axis in Alzheimer's disease: Integrating Global Burden of Disease data and Mendelian randomization analysis to reveal the causal role of osteocalcin

Zhiyang Zheng, Yifan Ren, Jingzhe Gao, Ke Yuan et autres

Abstract BACKGROUND Alzheimer's disease (AD) shows a significant sex disparity, with a higher incidence in women. Although reduced estradiol (E2) is a conventional explanation, inconsistent hormone‐replacement therapy outcomes suggest that other regulators, like the postmenopausal rise in follicle‐stimulating hormone (FSH), may be …

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Melatonin Alleviates Diquat-Induced Acute Liver Injury by Inhibiting Oxidative Stress and Ferroptosis via Activation of the Nrf2/HO-1 Pathway

Xia Lei, GuangHe Liu, Yuxin Dong, Fang Chen et autres

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Case Report: SMARCA4-deficient NSCLC with brain metastasis harboring co-mutations in chromatin remodeling and DNA damage repair pathways

Shikun Yang, Xia Lei

SMARCA4 (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4) is the core ATPase subunit of SWI/SNF chromatin remodeling complexes. Its deficiency constitutes a rare and aggressive subtype of non-small cell lung cancer (SMARCA4-DNSCLC) characterized by rapid progression, propensity for early …

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STING–FSP1 signaling drives endothelial ferroptosis and vascular leakage in sepsis

Tianyi Zhang, Yuxin Dong, Zhibo Li, Xia Lei et autres

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Oral microbiota: Roles and treatment in radiation injury (Review)

Xia Lei

While radiotherapy for malignant tumors increases the rate of local control for patients, it also inevitably causes damage to the surrounding normal tissues, resulting in different types and degrees of radiation injury (RI). RI has a significant negative impact on quality of …

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Curcumin inhibits aortic dissection progression: Insights from the integrated analysis of network pharmacology, gut microbiota, and serum metabolomics

S R Liu, Shuai Cheng, Xia Lei, Zhen Li

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Long‐term survival and association of neoadjuvant chemotherapy with or without immunotherapy in resectable esophageal squamous cell carcinoma

Lin Lu, Xia Lei, Xinhong Shi, Yingying Dai et autres

Long-term survival and association of neoadjuvant chemotherapy with

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Anemarrhena asphodeloides Bunge and Phellodendri Chinensis Cortex inhibits the PTGS2/EP2/cAMP/Epac1 signaling pathway to reduce microglial M1 polarization, thereby blocking chronic stress-induced depression-like behavior

Deping Zhao, Ao X, Ke Yuan, Kun Zuo et autres

Anemarrhena asphodeloides Bunge and Phellodendri Chinensis Cortex (AP) is a synergistic drug combination used to treat depression. However, the molecular mechanism underlying the therapeuticeffects of AP requires further elucidation. To investigate the potential of AP in the treatment of depression and its …

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Exploring the active components and potential mechanisms of Zhimu-Huangbai herb-pair in the treatment of depression

Xia Lei, Deping Zhao, Tongtong Chen, Qing Li et autres

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Calycosin-7-O-β-D-Glucoside Ameliorates Palmitate-Induced Lipid Accumulation in HT22 Cells

Yanming Xu, Dalong Li, Xue Ao, Jiaming Gu et autres

BACKGROUND: The pathogenesis of Alzheimer's disease (AD) is complex. Recent research suggests that AD patients have early disorders in brain cholesterol metabolism. Cholesterol and its derivatives accumulate in neurons, leading to p-Tau overproduction and synaptic dysfunction, initiating AD progression. Calycosin-7-O-β-D-glucoside (CG), a …

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Sofalcone attenuates neurodegeneration in MPTP-induced mouse model of Parkinson’s disease by inhibiting oxidative stress and neuroinflammation

Mulan Chen, Xin He, Yepeng Fan, Xia Lei et autres

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