A sex‐specific “hormone–bone–brain” axis in Alzheimer's disease: Integrating Global Burden of Disease data and Mendelian randomization analysis to reveal the causal role of osteocalcin
Zhiyang Zheng, Yifan Ren, Jingzhe Gao, Ke Yuan et autres
Abstract BACKGROUND Alzheimer's disease (AD) shows a significant sex disparity, with a higher incidence in women. Although reduced estradiol (E2) is a conventional explanation, inconsistent hormone‐replacement therapy outcomes suggest that other regulators, like the postmenopausal rise in follicle‐stimulating hormone (FSH), may be …
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Alzheimer s & Dementia Translational Research & Clinical Interventions