Accès ouvert
2025
conference-abstract
OpenAlex
Fatima Barbar‐Smiley, E.Q. Wu, Stéphane M. Gagné, P. Quartier et autres
Background: Pediatric antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a rare organ- and life-threatening autoimmune disease characterized by inflammation of small- to medium-sized blood vessels [1]. Despite the critical need for targeted therapies, clinical trials specifically addressing pediatric AAV remain limited, forcing …
us, fr, ca, be
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Accès ouvert
2025
article
OpenAlex
Fatima Barbar‐Smiley, Fengming Tang, Sandra Garcês, Amit Saxena et autres
PT014 / #285 Topic: AS24 - SLE-Treatment POSTER TOUR 03: RECENT ADVANCEMENTS IN SLE CLINICAL OUTCOMES AND THERAPY 23-05-2025 10:00 AM - 10:40 AM Background/Purpose SLE is a multisystem autoimmune disorder driven by diverse immunological mechanisms. Dysregulation of T and B cell …
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Accès ouvert
2024
article
OpenAlex
Y. Ingrid Goh, Meghan E. Ryan, Shoghik Akoghlanian, Rajdeep Pooni et autres
Introduction: Juvenile idiopathic arthritis (JIA) is the most common childhood rheumatic disease which is commonly monitored by a combination of history, physical examination, bloodwork, and imaging. The COVID-19 pandemic prompted a rapid shift to telemedicine to ensure that patients continued to receive …
ca, us
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Accès ouvert
2024
article
OpenAlex
Margaret H. Chang, Fatima Barbar‐Smiley, Shoghik Akoghlanian, Joanne Drew et autres
BACKGROUND: Chronic anterior uveitis (CAU) carries a significant risk for eye complications and vision loss. The Childhood Arthritis and Rheumatology Research Alliance (CARRA) introduced consensus treatment plans (CTPs) to standardize treatment for CAU and facilitate future comparative effectiveness studies. Two CTPs were …
us
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Accès ouvert
2024
article
OpenAlex
Fatima Barbar‐Smiley, Cagri Yildirim‐Toruner, Shoghik Akoghlanian, Ohoud AlAhmed et autres
Introduction: Childhood-onset systemic lupus erythematosus (c-SLE) presents unique challenges due to increased risk for severe morbidity and mortality compared to adult-onset SLE. Effective disease management relies on accurate disease assessment and documentation. Our project aimed to improve the documentation of the Lupus …
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2024
conference-abstract
OpenAlex
Danlei Zhou, Samantha Coss, Rabheh Abdul‐Aziz, Joanne Drew et autres
Abstract Complement activation on autologous cells causes tissue injuries but the process is not well studied. We seek to elucidate how C4 variants, their activation products and isotype deficiencies contribute to increased risks of children systemic lupus erythematous (cSLE) and juvenile dermatomyositis …
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Accès ouvert
2024
article
OpenAlex
Mona Riskalla, Fatima Barbar‐Smiley, Nicholas Marka, Melissa A. Lerman
OBJECTIVES: Treatment with tumour necrosis factor inhibitors (TNFi) has significantly improved outcomes in uveitis associated with juvenile idiopathic arthritis (JIA-U). This study examines a CARRA Registry cohort of JIA-U patients on TNFi to analyse utilisation patterns and identify factors associated with response. …
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Accès ouvert
2023
conference-abstract
OpenAlex
Samantha Coss, Rabheh Abdul‐Aziz, Danlei Zhou, Bi Zhou et autres
Abstract Juvenile dermatomyositis (JDM) is an autoimmune myopathy characterized by rash and muscle weakness. Complement C4 gene copy number (GCN) variation is a known risk factor for JDM. JDM patients often develop autoantibodies. We investigated the relationship between C4 GCN, clinical features, …
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Accès ouvert
2022
article
OpenAlex
Timothy Beukelman, George Tomlinson, Peter A. Nigrović, Anne Dennos et autres
BACKGROUND: The Childhood Arthritis and Rheumatology Research Alliance (CARRA) developed consensus treatment plans (CTPs) to compare treatment initiation strategies for systemic juvenile idiopathic arthritis (sJIA). First-line options for sJIA treatment (FROST) was a prospective observational study to assess CTP outcomes using the …
us, ca
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2022
article
OpenAlex
V. Mruk, Kelly Wise, Kyla Driest, Edward J. Oberle et autres
BACKGROUND: Adolescents with chronic disease engage in sexual activity similar to their healthy peers, with generally low utilization of contraception. Adolescents with rheumatic diseases prescribed teratogenic medications may be at risk for unplanned pregnancy. METHODS: Using structured quality improvement (QI) methods with …
us, cz
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Accès ouvert
2022
article
OpenAlex
Timothy Hahn, Carrie Daymont, Timothy Beukelman, Brandt Groh et autres
BACKGROUND: Children with juvenile idiopathic arthritis (JIA) who achieve a drug free remission often experience a flare of their disease requiring either intraarticular steroids (IAS) or systemic treatment with disease modifying anti-rheumatic drugs (DMARDs). IAS offer an opportunity to recapture disease control …
us
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Accès ouvert
2022
article
OpenAlex
Aliese Sarkissian, Edward J. Oberle, Ohoud Al Ahmed, Dawn Piccinich et autres
Introduction: Monitoring levels of 25-hydroxyvitamin D (25-OHD) is an integral part of bone health assessment in the general pediatric population, especially in at-risk populations such as children with juvenile idiopathic arthritis (JIA), childhood-onset systemic lupus erythematosus (c-SLE), and juvenile dermatomyositis (JDM). However, …
us, ru
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