Richard D. Hayward

Touching the invisible: exploring intracellular host–pathogen interactions through multisensory art

Rachel Elizabeth Jackson, Georgia Miller, Rachel Weild, Svetlana Atlavina et autres

The microscopic world of intracellular bacteria is rarely communicated to non-scientists. By participating in the Sensory Science Exhibition, held at St Catharine's College, University of Cambridge as part of the Cambridge Festival, we sought to address this problem by creating a 3D …

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Transcriptional reprogramming post-peripheral nerve injury: A systematic review

Richard D. Hayward, Spencer M. Moore, D. Artun, Ajay A. Madhavan et autres

Neuropathic pain is characterised by periodic or continuous hyperalgesia, numbness, or allodynia, and results from insults to the somatosensory nervous system. Peripheral nerve injury induces transcriptional reprogramming in peripheral sensory neurons, contributing to increased spinal nociceptive input and the development of neuropathic …

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Touching the Invisible: Communicating Intracellular Bacterial Pathogens through Multisensory Art

Rachel Jackson, Georgia Miller, Rachel Weild, Svetlana Atlavina et autres

Microbial life flourishes all around us and is invisible to the naked eye. Within this microscopic world are intracellular bacteria, including Salmonella enterica, Chlamydia trachomatis, and Orientia tsutsugamushi. By hijacking eukaryotic host cellular machinery and avoiding detection, these bacteria orchestrate their own …

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Outcomes following cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for peritoneal malignancies: 10 Year experience

Isabella Graham, Anna Boston, Richard D. Hayward, Richard Berri

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Does Mode of Transport Affect Outcomes in Trauma Patients? Data from an Urban Trauma Center

Lauren F. Messer, Richard D. Hayward, Elango Edhayan

Introduction: Trauma systems are designed to rapidly transport patients to their highest level of care by the Emergency Medical Services (EMS). Transport time to a trauma center (TC) may be a variable in decreasing the first and second peaks in trimodal trauma …

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Protamine use in transcarotid arterial revascularization

John J. Kanitra, Rebekah L Bjorklund, David J Clausen, Richard D. Hayward et autres

OBJECTIVE: The literature suggests that heparin reversal with protamine in transcarotid arterial revascularization (TCAR) decreases postoperative bleeding complications without an increase in stroke or death. However, the dosing of protamine in TCAR has not yet been evaluated. We aimed to evaluate our …

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Chlamydia Uses K+ Electrical Signalling to Orchestrate Host Sensing, Inter-Bacterial Communication and Differentiation

Susan C. Andrew, Maud Dumoux, Richard D. Hayward

Prokaryotic communities coordinate quorum behaviour in response to external stimuli to control fundamental processes including inter-bacterial communication. The obligate intracellular bacterial pathogen Chlamydia adopts two developmental forms, invasive elementary bodies (EBs) and replicative reticulate bodies (RBs), which reside within a specialised membrane-bound …

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A direct role for SNX9 in the biogenesis of filopodia.

Iris K. Jarsch, Jonathan R Gadsby, Annalisa Nuccitelli, Julia Mason et autres

Filopodia are finger-like actin-rich protrusions that extend from the cell surface and are important for cell-cell communication and pathogen internalization. The small size and transient nature of filopodia combined with shared usage of actin regulators within cells confounds attempts to identify filopodial …

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A direct role for SNX9 in the biogenesis of filopodia

Iris K. Jarsch, Jonathan R Gadsby, Annalisa Nuccitelli, Julia Mason et autres

Filopodia are finger-like actin-rich protrusions that extend from the cell surface and are important for cell-cell communication and pathogen internalization. The small size and transient nature of filopodia combined with shared usage of actin regulators within cells confounds attempts to identify filopodial …

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Protein Secretion in Chlamydia

Agathe Subtil, Richard D. Hayward

Containing nineteen chapters this comprehensive book is essential reading for every Chlamydia researcher. Topics covered range from an up-to-date review of the clinical infections to recent advances in chlamydial genetics and genomics.

The Pseudomonas aeruginosa T6SS Delivers a Periplasmic Toxin that Disrupts Bacterial Cell Morphology

Thomas E. Wood, Sophie A. Howard, Andreas Förster, Laura M. Nolan et autres

and confirm it is a member of the zinc-metallopeptidase family of enzymes. We show that this effector causes membrane blebbing at midcell, which suggests a distinct type of T6SS-mediated growth inhibition through interference with cell division, mimicking the impact of β-lactam antibiotics. …

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Impact of Alcohol and Illicit Drug Usage on Trauma Morbidity: A Review of Michigan Data

Edmund Michael Grady, Richard D. Hayward, Elango Edhayan

Grady, Edmund M. MD; Hayward, Richard D. PhD; Edhayan, Elango MBBS, FACS Author Information

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