Victor Gordon

A hierarchical mixed-effects modeling framework with Weibull reliability characterization for spatiotemporal throughput variability in cellular networks

Victor Gordon, Amevi Acakpovi

Reliable cellular throughput is essential for ensuring consistent user experience in modern mobile networks, yet it exhibits significant variability across spatial and operational conditions due to propagation effects, interference, and network congestion. This study proposes a hierarchical mixed-effects modeling framework integrated with …

Ghana (code pays fourni par la source)

Titre indisponible

Victor Gordon, Amevi Acakpovi

Reliable cellular throughput is essential for ensuring consistent user experience in modern mobile networks, yet it exhibits significant variability across spatial and operational conditions due to propagation effects, interference, and network congestion. This study proposes a hierarchical mixed-effects modeling framework integrated with …

Ghana (code pays fourni par la source)

Raindrop and bit drop effects on millimeter wave network performance: a critical review

Victor Gordon, Amevi Acakpovi, George Kwamena Aggrey, Michael Gameli Dziwornu

This PRISMA guided review examines how rain precipitation degrades 5G millimeter wave (mmWave) network performance, with emphasis on rain induced bit drop and its impact on end-to-end quality of service (QoS). From an initial corpus of 13,317 publications screened across IEEE Xplore, …

Ghana (code pays fourni par la source)

Strategic deployment of 5G mm Wave networks: a narrative review of technical challenges, socioeconomic imperatives and strategic pathways

Victor Gordon, Amevi Acakpovi, George K. Aggrey, Michael Gameli Dziwornu

The deployment of fifth-generation (5G) millimeter-wave (mmWave) networks represents a significant advancement in wireless communication, enabling peerless data capacity, near-instant responsiveness, and seamless connectivity for multiple devices. However, widespread implementation faces challenges such as high infrastructure costs, signal propagation limitations, interference management, …

Ghana (code pays fourni par la source)

STEM-09. A GROUP 3 MEDULLOBLASTOMA STEM CELL PROGRAM IS MAINTAINED BY OTX2-MEDIATED ALTERNATIVE SPLICING

Olivier Saulnier, Jamie L. Zagozewski, Lisa Liang, Liam D. Hendrikse et autres

Abstract Group 3 medulloblastomas (MBs) are highly metastatic pediatric brain tumors with limited therapeutic options. The transcription factor orthodenticle homeobox 2 (OTX2) is a known driver and molecular hallmark of Group 3 MB. We previously demonstrated that OTX2 regulates Group 3 MB …

fr, ca, us (code pays fourni par la source)

A group 3 medulloblastoma stem cell program is maintained by OTX2-mediated alternative splicing

Olivier Saulnier, Jamie L. Zagozewski, Lisa Liang, Liam D. Hendrikse et autres

OTX2 is a transcription factor and known driver in medulloblastoma (MB), where it is amplified in a subset of tumours and overexpressed in most cases of group 3 and group 4 MB. Here we demonstrate a noncanonical role for OTX2 in group …

fr, ca, us, gb (code pays fourni par la source)

MDB-06. ALTERNATIVE SPLICING MEDIATED BY OTX2 DRIVES THE DEVELOPMENT OF GROUP 3 MEDULLOBLASTOMA

Olivier Saulnier, Jamie L. Zagozewski, Lisa Liang, Liam D. Hendrikse et autres

Abstract BACKGROUND OTX2 is a transcription factor and known molecular hallmark of Group 3 medulloblastoma (MB). While previous studies have focused on its association with active enhancer elements to modulate the chromatin landscape, here, we demonstrate an unexpected role for OTX2 in …

fr, ca, us (code pays fourni par la source)

MDB-21. THE OTX2-REGULATED ALTERNATIVE SPLICING LANDSCAPE CONTROLS DIFFERENTIATION AND RECONSTITUTES THE DEVELOPMENTAL ORIGINS OF GROUP 3 MEDULLOBLASTOMA

Olivier Saulnier, Jamie L. Zagozewski, Lisa Liang, Liam D. Hendrikse et autres

Abstract Medulloblastoma (MB) is the most common malignant primary pediatric brain tumor with Group 3 MB exhibiting the worst prognosis. Overexpression/amplification of OTX2 is a molecular hallmark of Group 3 MB and is primarily known to control tumor growth through regulation of …

ca, us (code pays fourni par la source)

Author Correction: Failure of human rhombic lip differentiation underlies medulloblastoma formation

Liam D. Hendrikse, Parthiv Haldipur, Olivier Saulnier, Jake Millman et autres

ca, us, fr, de, kr, pl, nl, cz, hu, es, hk, mx, jp, it, br, pt (code pays fourni par la source)

Failure of human rhombic lip differentiation underlies medulloblastoma formation

Liam D. Hendrikse, Parthiv Haldipur, Olivier Saulnier, Jake Millman et autres

ca, us, fr, de, kr, pl, nl, cz, hu, es, hk, mx, jp, it, br, pt (code pays fourni par la source)

Combined MEK and JAK/STAT3 pathway inhibition effectively decreases SHH medulloblastoma tumor progression

Jamie L. Zagozewski, Stephanie Borlase, Brent J. Guppy, Ludivine Coudière-Morrison et autres

Medulloblastoma (MB) is the most common primary malignant pediatric brain cancer. We recently identified novel roles for the MEK/MAPK pathway in regulating human Sonic Hedgehog (SHH) MB tumorigenesis. The MEK inhibitor, selumetinib, decreased SHH MB growth while extending survival in mouse models. …

ca, us (code pays fourni par la source)

An empirical assessment of information security best practices and information technology disaster recovery readiness in Ghanaian micro-finance sector

Stephen Bekoe, Victor Gordon, Paul Danquah