Stephanie Borlase

A kit formulated under good manufacturing practices (GMP) for preparing [89Zr]Zr-Bn-DFO-Pembrolizumab injection for human administration and associated preclinical imaging, biodistribution, dosimetry and toxicity studies

Stephanie Borlase, Conrad Chan, Zhongli Cai, Raymond M. Reilly

PET with [ 89 Zr]Zr-Bn-DFO-pembrolizumab is a potential imaging biomarker to assess delivery of pembrolizumab to tumours and predict response to PD-1 checkpoint immunotherapy. Clinical quality [ 89 Zr]Zr-Bn-DFO-pembrolizumab injection has been prepared under Good Manufacturing Practices (GMP) through multistep radiolabeling processes …

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Treatment of Human Glioblastoma Multiforme in NRG Mice by Convection-Enhanced Delivery of EGFR-Targeted or Nontargeted Auger Electron–Emitting 197g Hg-Labeled Gold Nanoparticles

Madeline K. Brown, Zhongli Cai, Yumeela Ganga-Sah, Laila Alshafai et autres

The effectiveness and safety of Auger electron (AE)–emitting epidermal growth factor receptor (EGFR)–targeted panitumumab-197gHg-gold nanoparticles (AuNPs) or nontargeted 197gHg-AuNPs for treating glioblastoma multiforme (GBM) were studied after convection-enhanced delivery (CED) in NOD-Rag1nullIL2rgnull (NRG) mice with orthotopic GBM tumors. We hypothesized that EGFR …

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STEM-09. A GROUP 3 MEDULLOBLASTOMA STEM CELL PROGRAM IS MAINTAINED BY OTX2-MEDIATED ALTERNATIVE SPLICING

Olivier Saulnier, Jamie L. Zagozewski, Lisa Liang, Liam D. Hendrikse et autres

Abstract Group 3 medulloblastomas (MBs) are highly metastatic pediatric brain tumors with limited therapeutic options. The transcription factor orthodenticle homeobox 2 (OTX2) is a known driver and molecular hallmark of Group 3 MB. We previously demonstrated that OTX2 regulates Group 3 MB …

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A group 3 medulloblastoma stem cell program is maintained by OTX2-mediated alternative splicing

Olivier Saulnier, Jamie L. Zagozewski, Lisa Liang, Liam D. Hendrikse et autres

OTX2 is a transcription factor and known driver in medulloblastoma (MB), where it is amplified in a subset of tumours and overexpressed in most cases of group 3 and group 4 MB. Here we demonstrate a noncanonical role for OTX2 in group …

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MDB-06. ALTERNATIVE SPLICING MEDIATED BY OTX2 DRIVES THE DEVELOPMENT OF GROUP 3 MEDULLOBLASTOMA

Olivier Saulnier, Jamie L. Zagozewski, Lisa Liang, Liam D. Hendrikse et autres

Abstract BACKGROUND OTX2 is a transcription factor and known molecular hallmark of Group 3 medulloblastoma (MB). While previous studies have focused on its association with active enhancer elements to modulate the chromatin landscape, here, we demonstrate an unexpected role for OTX2 in …

fr, ca, us (code pays fourni par la source)

Cross-species analysis of SHH medulloblastoma models reveals significant inhibitory effects of trametinib on tumor progression

Stephanie Borlase, Alexandria DeCarlo, Ludivine Coudière-Morrison, Lisa Liang et autres

Sonic Hedgehog (SHH) medulloblastomas (MBs) exhibit an intermediate prognosis and extensive intertumoral heterogeneity. While SHH pathway antagonists are effective in post-pubertal patients, younger patients exhibit significant side effects, and tumors that harbor mutations in downstream SHH pathway genes will be drug resistant. …

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MDB-21. THE OTX2-REGULATED ALTERNATIVE SPLICING LANDSCAPE CONTROLS DIFFERENTIATION AND RECONSTITUTES THE DEVELOPMENTAL ORIGINS OF GROUP 3 MEDULLOBLASTOMA

Olivier Saulnier, Jamie L. Zagozewski, Lisa Liang, Liam D. Hendrikse et autres

Abstract Medulloblastoma (MB) is the most common malignant primary pediatric brain tumor with Group 3 MB exhibiting the worst prognosis. Overexpression/amplification of OTX2 is a molecular hallmark of Group 3 MB and is primarily known to control tumor growth through regulation of …

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Primary Pediatric Brain Tumors of the Posterior Fossa: Part II A Comprehensive Overview of Medulloblastoma

Lisa Liang, Stephanie Borlase, Christopher R. Aiken, Kathleen E. A. Felton et autres

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Author Correction: Failure of human rhombic lip differentiation underlies medulloblastoma formation

Liam D. Hendrikse, Parthiv Haldipur, Olivier Saulnier, Jake Millman et autres

ca, us, fr, de, kr, pl, nl, cz, hu, es, hk, mx, jp, it, br, pt (code pays fourni par la source)

Failure of human rhombic lip differentiation underlies medulloblastoma formation

Liam D. Hendrikse, Parthiv Haldipur, Olivier Saulnier, Jake Millman et autres

ca, us, fr, de, kr, pl, nl, cz, hu, es, hk, mx, jp, it, br, pt (code pays fourni par la source)

Combined MEK and JAK/STAT3 pathway inhibition effectively decreases SHH medulloblastoma tumor progression

Jamie L. Zagozewski, Stephanie Borlase, Brent J. Guppy, Ludivine Coudière-Morrison et autres

Medulloblastoma (MB) is the most common primary malignant pediatric brain cancer. We recently identified novel roles for the MEK/MAPK pathway in regulating human Sonic Hedgehog (SHH) MB tumorigenesis. The MEK inhibitor, selumetinib, decreased SHH MB growth while extending survival in mouse models. …

ca, us (code pays fourni par la source)