Giovanni Natile

Lothar Meyer’s contribution to the transition between the early (1869) and later (1872) formulation of Mendeleev’s periodic table

Fabio Arnesano, Giovanni Natile

it (code pays fourni par la source)

Probing the interaction of cisplatin with calmodulin and its effect upon binding to myosin light-chain kinase

Siming Yuan, S. Wang, Kaiming Cao, Yu Wang et autres

Cisplatin inhibits the interaction between CaM and MLCK, leading to the mobilization of bound Ca 2+ ions and disruption of CaM functions. The findings provide mechanistic insights into the neurotoxicity caused by the drug.

cn, it (code pays fourni par la source)

Interactions with DNA Models of the Oxaliplatin Analog (cis-1,3-DACH)PtCl2

Alessandra Barbanente, Paride Papadia, Anna Maria Di Cosola, Concetta Pacifico et autres

It is generally accepted that adjacent guanine residues in DNA are the primary target for platinum antitumor drugs and that differences in the conformations of the Pt-DNA adducts can play a role in their antitumor activity. In this study, we investigated the …

it, us (code pays fourni par la source)

Hydrophobic Nanocrystals Coated with an Amphiphilic Polymer Shell: A General Route to Water Soluble Nanocrystals

Teresa Pellegrino, Liberato Manna, Stefan Kudera, Tim Liedl et autres

A general strategy is described which allows for transferring hydrophobically capped nanocrystals from organic to aqueous solution by wrapping an amphiphilic polymer around the particles. In particular, high quality CoPt 3 , Au, CdSe/ZnS, and Fe 2 O 3 nanocrystals have been …

Cisplatin and zoledronic acid: two drugs combined in a Pt( ii ) complex with potential antitumor activity towards bone tumors and metastases

Alessandra Barbanente, Nicoletta Ditaranto, Antonio Laghezza, Paolo Tortorella et autres

Two drugs already approved by the U.S. Food and Drug Administration and the European Medicinal Agency combined in a dinuclear Pt( ii ) complex.

it (code pays fourni par la source)

Pt( ii ) and Pt( iv ) complexes with a major component of royal jelly as innovative antitumor drug candidates

Alessandra Barbanente, Valentina Gandin, Chiara Donati, Carmela Ilaria Pierro et autres

The major and unique fatty acid in Royal Jelly, trans -10-hydroxy-2-decenoic acid, which have anti-tumor, immunomodulatory, and other properties, has been combined with the antitumor platinum moiety of clinically used oxaliplatin.

it (code pays fourni par la source)

Crystal Structure of the Human Copper Chaperone ATOX1 Bound to Zinc Ion

Vincenzo Mangini, Benny Danilo Belviso, Maria Incoronata Nardella, Giovanni Natile et autres

The bioavailability of copper (Cu) in human cells may depend on a complex interplay with zinc (Zn) ions. We investigated the ability of the Zn ion to target the human Cu-chaperone Atox1, a small cytosolic protein capable of anchoring Cu(I), by a …

it (code pays fourni par la source)

Improvement of Kiteplatin Efficacy by a Benzoato Pt(IV) Prodrug Suitable for Oral Administration

Alessandra Barbanente, Valentina Gandin, C Ceresa, Cristina Marzano et autres

Kiteplatin, [PtCl2(cis-1,4-DACH)] (DACH = diaminocyclohexane), contains an isomeric form of the oxaliplatin diamine ligand trans-1R,2R-DACH and has been proposed as a valuable drug candidate against cisplatin- and oxaliplatin-resistant tumors, in particular, colorectal cancer. To further improve the activity of kiteplatin, it has …

it, us (code pays fourni par la source)

Multinuclear Metal-Binding Ability of the N-Terminal Region of Human Copper Transporter Ctr1: Dependence Upon pH and Metal Oxidation State

Maria Incoronata Nardella, Mariagrazia Fortino, Alessandra Barbanente, Giovanni Natile et autres

The 14mer peptide corresponding to the N-terminal region of human copper transporter Ctr1 was used to investigate the intricate mechanism of metal binding to this plasma membrane permease responsible for copper import in eukaryotic cells. The peptide contains a high-affinity ATCUN Cu(II)/Ni(II)-selective …

it (code pays fourni par la source)

19F NMR Allows the Investigation of the Fate of Platinum(IV) Prodrugs in Physiological Conditions

Siming Yuan, Yang Zhu, Yi Dai, Yu Wang et autres

Abstract PtIV prodrugs can overcome resistance and side effects of conventional PtII anticancer therapies. By 19F‐labeling of a PtIV prodrug (Pt‐FBA, FBA=p‐fluorobenzoate), the activation under physiological conditions could be investigated. Unlike single‐electron reductants, multi‐electron agents can efficiently promote the two electrons reduction …

cn, it (code pays fourni par la source)

19F NMR Allows the Investigation of the Fate of Platinum(IV) Prodrugs in Physiological Conditions

Siming Yuan, Yang Zhu, Yi Dai, Yu Wang et autres

Abstract PtIV prodrugs can overcome resistance and side effects of conventional PtII anticancer therapies. By 19F‐labeling of a PtIV prodrug (Pt‐FBA, FBA=p‐fluorobenzoate), the activation under physiological conditions could be investigated. Unlike single‐electron reductants, multi‐electron agents can efficiently promote the two electrons reduction …

cn, it (code pays fourni par la source)

CCDC 2093057: Experimental Crystal Structure Determination

Nicola Margiotta, Concetta Pacifico, Teresa Saltarella, Giovanni Natile et autres