Victor W. Macdonald

Characterization and first‐in‐human clinical dose‐escalation safety evaluation of a next‐gen human freeze‐dried plasma

José A. Cancelas, Shawnagay V. Nestheide, Neeta Rugg, Anna Eckerman et autres

BACKGROUND: Early plasma transfusion is life-saving for bleeding trauma patients. Freeze-dried plasma (FDP) provides unique formulation advantages for infusion in the prehospital setting. We describe characterization and clinical safety data of the first, next-generation FDP stored in plastic bags with rapid reconstitution. …

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Safety and efficacy of cryopreserved platelets in bleeding patients with thrombocytopenia

Sherrill J. Slichter, Larry J. Dumont, José A. Cancelas, MeLinh Jones et autres

BACKGROUND: The short dating period of room temperature-stored platelets (PLTs; 5-7 days) limits their availability at far-forward combat facilities and at remote civilian sites in the United States. PLT cryopreservation in 6% DMSO and storage for up to 2 years may improve …

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Treatment of Bleeding in Severely Thrombocytopenic Patients with Transfusion of Dimethyl Sulfoxide (DMSO) Cryopreserved Platelets (CPP) Is Safe - Report of a Phase 1 Dose Escalation Safety Trial

Sherrill J. Slichter, Larry J. Dumont, José A. Cancelas, Terry Gernsheimer et autres

Abstract Availability of platelets (plts) is severely limited by shelf life in some military as well as civilian settings. Additionally, some bleeding, thrombocytopenic patients do not have a therapeutic response to a standard plt transfusion. Methods for cryopreservation of apheresis plts for …

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Dried plasma: state of the science and recent developments

Anthony E. Pusateri, Michael B. Given, Martin A. Schreiber, Philip Charles Spinella et autres

The early transfusion of plasma is important to ensure optimal survival of patients with traumatic hemorrhage. In military and remote or austere civilian settings, it may be impossible to move patients to hospital facilities within the first few hours of injury. A …

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Comprehensive US government program for dried plasma development

Anthony E. Pusateri, Michael B. Given, Victor W. Macdonald, Mary J. Homer

Transfusion of plasma early after severe injury has been associated with improved survival. There are significant logistic factors that limit the ability to deliver plasma where needed in austere environments, such as the battlefield or during a significant civilian emergency. While some …

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US Army blood program: 2025 and beyond

Richard Gonzales, Audra L. Taylor, Andrew J. Atkinson, Wilbur W. Malloy et autres

In preparing to support the Army in 2025 and beyond, the Army Blood Program remains actively engaged with the research and advanced development of blood products and medical technology to improve blood safety and efficacy in conjunction with the US Army Medical …

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Bridging the Technology Valley of Death in Joint Medical Development

Anthony E. Pusateri, Victor W. Macdonald, Michael B. Given, Scott F. Walter et autres

Abstract : One of the most difficult transitions in a products life cycle is the transition from the science and technology (S and T) environment to advanced development (AD). Transition planning is necessary to bridge this technology Valley of Death in which …

CARDIOGENIC SHOCK IN A FORTY YEAR OLD FEMALE: COULD VASCULAR GENETICS PLAY A ROLE?

Victor W. Macdonald, J. Doherty, Susan Jane Morris

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Tranexamic Acid and Trauma

Anthony E. Pusateri, Richard B. Weiskopf, Vikhyat S. Bebarta, Frank K. Butler et autres

A recent large civilian randomized controlled trial on the use of tranexamic acid (TXA) for trauma reported important survival benefits. Subsequently, successful use of TXA for combat casualties in Afghanistan was also reported. As a result of these promising studies, there has …

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Laboratory evaluation of rapid test kits to detect hepatitis C antibody for use in predonation screening in emergency settings

Robert J. O’Connell, Robert Gates, Christian T. Bautista, Michelle Imbach et autres

BACKGROUND: Emergency whole blood transfusion is a lifesaving procedure employed on modern battlefields. Rapid device tests (RDTs) are frequently used to mitigate transfusion-transmitted infection risks. STUDY DESIGN AND METHODS: A limited evaluation of the RDT formerly used on battlefields was performed using …

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A randomized controlled trial evaluating recovery and survival of 6% dimethyl sulfoxide–frozen autologous platelets in healthy volunteers

Larry J. Dumont, José A. Cancelas, Deborah F. Dumont, Alan H. Siegel et autres

BACKGROUND: Availability of platelets (PLTs) is severely limited by shelf life in some settings. Our objective was to determine and compare to Food and Drug Administration (FDA) criteria the PLT recovery and survival of autologous PLTs cryopreserved at -65°C or less in …

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Low Oxygen Affinity Hemoglobin HBOC‐201 enables increased Oxygen Uptake (VO2) In Bovine Pulmonary Artery Endothelial Cells (BPAEC)

John Karaian, Paul D. Mongan, Victor W. Macdonald, Rolf Bünger

Hemoglobin‐based oxygen carriers (HBOCs) with various oxygen affinities are currently being evaluated for clinical use. We tested whether HBOCs with high vs. low oxygen affinities can affect cellular oxygen uptake (VO 2 ), using a BPAEC model. Methods: Confluent BPAECs, passages 3–6, …

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