Safety and efficacy of cryopreserved platelets in bleeding patients with thrombocytopenia
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Le résumé fourni par la source
BACKGROUND: The short dating period of room temperature-stored platelets (PLTs; 5-7 days) limits their availability at far-forward combat facilities and at remote civilian sites in the United States. PLT cryopreservation in 6% DMSO and storage for up to 2 years may improve timely availability for bleeding patients. STUDY DESIGN AND METHODS: A dose escalation trial of DMSO-cryopreserved PLTs (CPPs) compared to standard liquid-stored PLTs (LSPs) was performed in bleeding patients with thrombocytopenia. Within each of four cohorts, six patients received escalating doses of CPP (0.5 unit, 1 unit, and sequential transfusions of 2 and 3 units) and one received a LSP transfusion. Patients were monitored for adverse events (AEs), coagulation markers, PLT responses, and hemostatic efficacy. RESULTS: Patients with a World Health Organization bleeding score of 2 or more received from 0.5 to 3 units of CPP (n = 24) or 1 unit of LSP (n = 4). There were no related thrombotic or other serious AEs experienced. Mild transfusion-related AEs of chills and fever (n = 1), transient increased respiratory rate (n = 1), DMSO-related skin odor (n = 2), and headache (n = 1) were observed after CPP transfusion. Among CPP recipients 14 of 24 (58%) had improved bleeding scores, including three of seven (43%) patients who had intracerebral bleeding. CPP posttransfusion PLT increments were significantly less than those of LSPs; however, days to next transfusion were the same. After transfusion, the CPP recipients had improvements in some variables of thrombin generation tests and thromboelastography. CONCLUSION: Cryopreserved PLT transfusions appear to be safe and effective when given to bleeding patients with thrombocytopenia.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Safety and efficacy of cryopreserved platelets in bleeding patients with thrombocytopenia
- Date Crossref
- 01/09/2018
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Washington pays non établi dans la noticeUniversité ou école supérieure
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Bloodworks Northwest pays non établi dans la noticeOrganisation à but non lucratif
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Dartmouth–Hitchcock Medical Center pays non établi dans la noticeÉtablissement de santé
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Blood Systems Research Institute pays non établi dans la noticeOrganisation à but non lucratif
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University of Cincinnati pays non établi dans la noticeUniversité ou école supérieure
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United States Army Medical Research and Development Command pays non établi dans la noticeStructure de recherche
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Fast Track Drugs and Biologics pays non établi dans la noticeInstitution
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Geisel School of Medicine at Dartmouth and Dartmouth‐Hitchcock Medical Center Lebanon New Hampshire pays non établi dans la noticeUniversité ou école supérieure
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U.S. Army Medical Research and Materiel Command Fort Detrick Maryland pays non établi dans la noticeInstitution
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Fast‐Track Drugs & pays non établi dans la noticeInstitution
University of Washington, Bloodworks Northwest et Dartmouth–Hitchcock Medical Center, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.