Lei Xi

Simultaneous mesoscopic imaging of neural activity and hemodynamics reveals anesthetic modulation of neurovascular responses

Ruyi Wen, Wei Qin, Baochen Li, Tingting Li et autres

Anesthesia substantially alters neural activity and vascular tone, yet its state-dependent modulation of cortical neurovascular coupling (NVC) remains incompletely characterized. Here, using an established multimodal optical imaging platform that synchronizes wide-field fluorescence microscopy, photoacoustic microscopy, and laser speckle contrast imaging, we investigated …

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Resolving Acoustic Temporal Aliasing in High‐Throughput Photoacoustic Microscopy Through Spatial Division Multiplexing

Tingting Li, Weizhi Qi, Wei Qin, Linyang Li et autres

ABSTRACT Laser pulse repetition rate (PRR) is a critical factor determining the spatial‐bandwidth‐product of high‐throughput photoacoustic microscopy (PAM). However, there exists a fundamental conflict between PRR and effective imaging depth for high‐throughput PAM, which causes acoustic temporal aliasing due to limited acoustic …

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Waste-derived graphene quantum dots on paper-based electrodes for electrochemiluminescence screening of tetracycline

Yinfeng Wang, Hu Zou, Ruitao Duan, Shunshun Bao et autres

chemical vapor deposition and electrochemical exfoliation and subsequently introduced into the reaction zone of screen-printed paper electrodes to form a low-cost analytical platform. Control experiments and spectral-overlap analysis suggest that perturbation of the sulfate-radical-dependent ECL pathway and a possible inner filter effect …

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Wearable photoacoustic microscopy for ultrafast stroke metabolic imaging in freely moving mice

Xiao Qin Liang, Heng Guo, Linyang Li, Tingting Li et autres

Understanding cerebral oxygen metabolism in freely moving animals is essential for uncovering neural mechanisms underlying brain function. However, existing methods are limited by a narrow field of view and low temporal resolution, hindering comprehensive observation and dynamic analysis. We present a miniaturized, …

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A cortex-wide multimodal microscope for simultaneous Ca2+ and hemodynamic imaging in awake mice

Wei Qin, Tingting Li, Linyang Li, Tian Jin et autres

Developments in optical imaging techniques have advanced the study of neurovascular coupling across the whole cortex. Unfortunately, each cortex-wide optical imaging modality is specialized in revealing limited neural or hemodynamic actions. Here, we develop a cortex-wide multimodal microscope (multiScope) integrating widefield Ca2+ …

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Multi-scenario photoacoustic endoscopy for in vivo functional imaging

Xiao Qin Liang, Yuanlong Zhao, Linyang Li, Wei Qin et autres

Optical endoscopy has been extensively used in clinical screening and diagnosis of internal diseased organs. Photoacoustic endoscopy, one of the rapidest evolving optical endoscopies, combines rich optical contrasts with high spatial acoustic resolving capability at a considerable penetration depth. However, implementing high-speed, …

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An Efficient Heat and Peroxynitrite Generating Nanoplatform for Multimodal Imaging‐guided Precision Tumor Phototherapy

Ziyi Xu, Mingkun Lv, Jingkai Yang, Tingting Li et autres

ABSTRACT Near‐infrared II (NIR‐II) fluorescent nanoparticles (NPs) based on aggregation‐induced emission (AIE) have attracted significant attention due to their multimodal imaging capabilities as well as the combined photothermal and photodynamic therapeutic effects in cancer therapy. Reported herein is the rational designed AIE …

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High‐Efficiency Photoacoustic Microscopy for Ultrafast Hemodynamic Imaging

Wei Qin, Tingting Li, Yifan Chen, Xiao Liang et autres

Abstract Understanding brain functions requires visualization of cerebral hemodynamics with a high spatiotemporal resolution. Recent advances utilize various scanning schemes to promote the imaging speed of photoacoustic microscopy for label‐free hemodynamic imaging. However, due to the insufficient utilization of laser pulses, recording …

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Dual-Scanning Photoacoustic Endomicroscopy for High-Speed Gastrointestinal Microvascular Imaging

Xiao Qin Liang, Linyang Li, Heng Guo, Weizhi Qi et autres

Photoacoustic endomicroscopy enables high-resolution imaging of deep microvasculature within the gastrointestinal wall using modulated laser pulses with point-by-point scanning. However, conventional scanning mechanisms frequently encounter difficulties in balancing imaging speed and field of view, particularly when imaging the peristaltic gastrointestinal tract. To …

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Hybrid Membrane Biomimetic Photothermal Nanorobots for Enhanced Chemodynamic-Chemotherapy-Immunotherapy

Xiaoxia Song, Hongkai Zhao, Rongxin Qian, Lijun Fang et autres

Glioblastoma multiforme (GBM) is a highly invasive and fatal brain tumor with a grim prognosis, where current treatment modalities, including postoperative radiotherapy and temozolomide chemotherapy, yield a median survival of only 15 months. The challenges of tumor heterogeneity, drug resistance, and the …

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Mixed or Misperceived Reality? Flusserian Media Freedom through Surreal Me

Aven-Le Zhou, Lei Xi, Kang Zhang

This paper delves into Vilém Flusser's critique of media as mediators that distort the human perception of reality and diminish freedom, particularly within the Mixed Reality context, i.e., Misperceived Reality. It introduces an artistic inquiry through Surreal Me, which engages participants to …

SKYQUANT 3D : Quantifying Vascular Anatomy With an Open‐Source Workflow for Comprehensive Analysis of Volumetric Optoacoustic Angiography Data

Artemii Korobov, Zlata V. Besedovskaia, Elizaveta Petrova, Alexey A. Kurnikov et autres

Efficient visualization of the vascular system is of key importance in biomedical research into tumor angiogenesis, cerebrovascular alterations, and other angiopathies. Optoacoustic (OA) angiography offers a promising solution combining molecular optical contrast with high resolution and deep penetration of ultrasound. However, its …

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