Sara Amidian

A Müller glia-retinal pigment epithelium apical network surrounding cone outer segments in fish and mouse

Maria Sharkova, Michael Housset, Samantha Boudreau, Chavy Dworkind et autres

Abstract Homeostasis of the vertebrate retina critically depends on two non-neuronal cell populations, Müller glia and the retinal pigment epithelium (RPE). Their opposing apical surfaces delineate the subretinal space, a specialized extracellular compartment housing the light-detecting outer segments of photoreceptors. Although the …

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Vaccines mimicking conformational epitopes on α-synuclein fibrils provide immunity to Parkinson’s disease

Liang Ma, Sara Reithofer, Verena Pesch, José Miguel Flores-Fernández et autres

The progressive age-related aggregation of soluble α-synuclein into toxic oligomers and insoluble amyloid fibrils causes Parkinson's disease, Lewy body dementia and multiple system atrophy, all of which are neurodegenerative diseases without a cure. Because α-synuclein is a self-antigen, pathogenic α-synuclein aggregates do …

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The pore-forming apolipoprotein APOL7C drives phagosomal rupture and antigen cross-presentation by dendritic cells

Gerone A. Gonzales, Song Huang, Liam Wilkinson, Jenny A. Nguyen et autres

Conventional dendritic cells (cDCs) generate protective cytotoxic T lymphocyte (CTL) responses against extracellular pathogens and tumors. This is achieved through a process known as cross-presentation (XP), and, despite its biological importance, the mechanism(s) driving XP remains unclear. Here, we show that a …

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Rational design of structure‐based vaccines targeting misfolded alpha‐synuclein conformers of Parkinson's disease and related disorders

José Miguel Flores-Fernández, Verena Pesch, Aishwarya Sriraman, Enrique Chimal‐Juárez et autres

Synucleinopathies, including Parkinson's disease (PD), multiple system atrophy (MSA), and dementia with Lewy bodies (DLB), are neurodegenerative disorders caused by the accumulation of misfolded alpha-synuclein protein. Developing effective vaccines against synucleinopathies is challenging due to the difficulty of stimulating an immune-specific response …

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Vaccination with structurally adapted fungal protein fibrils induces immunity to Parkinson’s disease

Verena Pesch, José Miguel Flores-Fernández, Sara Reithofer, Liang Ma et autres

The pathological misfolding and aggregation of soluble α-synuclein into toxic oligomers and insoluble amyloid fibrils causes Parkinson's disease, a progressive age-related neurodegenerative disease for which there is no cure. HET-s is a soluble fungal protein that can form assembled amyloid fibrils in …

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Author response for "Rational design of structure‐based vaccines targeting misfolded alpha‐synuclein conformers of Parkinson's disease and related disorders"

José Miguel Flores-Fernández, Verena Pesch, Aishwarya Sriraman, Enrique Chimal‐Juárez et autres

Rational design of structure-based vaccines targeting misfolded alpha-synuclein conformers of Parkinson’s disease and related disorders

José Miguel Flores-Fernández, Verena Pesch, Aishwarya Sriraman, Enrique Chimal‐Juárez et autres

Abstract Background Synucleinopathies, including Parkinson’s disease, multiple system atrophy, and dementia with Lewy bodies, are neurodegenerative disorders caused by the accumulation of misfolded alpha-synuclein protein. Developing effective vaccines against synucleinopathies has been challenging due to the difficulty of stimulating an immune-specific response …

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Significance of native PLGA nanoparticles in the treatment of Alzheimer's disease pathology

Bibin Gnanadhason Anand, Qi Wu, Maryam Nakhaei‐Nejad, Govindarajan Karthivashan et autres

Alzheimer's disease (AD) is believed to be triggered by increased levels/aggregation of β-amyloid (Aβ) peptides. At present, there is no effective disease-modifying treatment for AD. Here, we evaluated the therapeutic potential of FDA-approved native poly(d,l-lactide-co-glycolide) (PLGA) nanoparticles on Aβ aggregation and in …

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The ultrastructure of infectious L-type bovine spongiform encephalopathy prions constrains molecular models

Razieh Kamali-Jamil, Ester Vázquez-Fernández, Brian P. Tancowny, Vineet Rathod et autres

Bovine spongiform encephalopathy (BSE) is a prion disease of cattle that is caused by the misfolding of the cellular prion protein (PrPC) into an infectious conformation (PrPSc). PrPC is a predominantly α-helical membrane protein that misfolds into a β-sheet rich, infectious state, …

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Mimosine functionalized gold nanoparticles (Mimo-AuNPs) suppress β-amyloid aggregation and neuronal toxicity

Bibin Gnanadhason Anand, Qi Wu, Govindarajan Karthivashan, Kiran P. Shejale et autres

Evidence suggests that increased level/aggregation of beta-amyloid (Aβ) peptides initiate neurodegeneration and subsequent development of Alzheimer's disease (AD). At present, there is no effective treatment for AD. In this study, we reported the effects of gold nanoparticles surface-functionalized with a plant-based amino …

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Structural polymorphisms in fibrillar aggregates associated with exfoliation syndrome

Mehdi Ghaffari Sharaf, Sara Amidian, Vineet Rathod, Andrew C. S. Crichton et autres

Exfoliation syndrome is largely considered an age-related disease that presents with fibrillar aggregates in the front part of the eye. A growing body of literature has investigated structural diversity of amyloids and fibrillar aggregates associated with neurodegenerative disease. However, in case of …

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Combining molecular dynamics simulations and experimental analyses in protein misfolding

Holger Wille, Lyudmyla Dorosh, Sara Amidian, Gerold Schmitt‐Ulms et autres

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