Thomas P. Cappola

Clonal Hematopoiesis of Indeterminate Potential Proteomic Risk Score for Predicting Clinical Outcome in Patients With Heart Failure With Preserved Ejection Fraction

Minkwan Kim, Vinayak Subramanian, Hamed Tavolinejad, Mateo Sarmiento Bustamante et autres

BACKGROUND: Clonal hematopoiesis of indeterminate potential (CHIP) is common in heart failure with preserved ejection fraction (HFpEF). However, the proteomic signatures linked to CHIP driver mutations and their prognostic implications in HFpEF remain poorly defined. We aimed to identify plasma protein signatures …

kr, us, sg, nz, be, nl (code pays fourni par la source)

Pathway Modeling of Genomic and Tissue-Specific Transcriptomic Architecture Identifies Personalized Mechanisms of Atrial Fibrillation Risk †

Rasika Venkatesh, Rajat Deo, Thomas P. Cappola, Penn Medicine BioBank et autres

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and a major cause of cardioembolic stroke. Although polygenic risk scores (PRS) are well characterized to quantify inherited susceptibility for AF, they provide limited insight into the pathways and tissues underlying genetic …

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Body Mass Index, Clinical Outcomes, and Mortality in Heart Failure: A Mendelian Randomization Study

Nicholas Sunderland, Géraldine Asselin, Albert Henry, Christopher P. Nelson et autres

Background: Excess adiposity, most commonly indexed through body mass index (BMI), is strongly associated with the development of heart failure (HF). Weight loss therapies improve outcomes in patients with obesity and HF with preserved left ventricular ejection fraction (LVEF), but their effects …

Roadmap to Revitalizing Academic Cardiovascular Medicine

Sadeer Al-Kindi, Michael P. Ayers, Gloria Ayuba, Matthew A. Cavender et autres

us (code pays fourni par la source)

Body Mass Index, Clinical Outcomes, and Mortality in Heart Failure

Nicholas P. Sunderland, Géraldine Asselin, Albert Carl Henry, Christopher P. Nelson et autres

BACKGROUND: Excess adiposity, most commonly indexed through body mass index (BMI), is strongly associated with the development of heart failure (HF). Weight loss therapies improve outcomes in patients with obesity and HF with preserved left ventricular ejection fraction (LVEF), but their effects …

gb, ca, nl, us, se, my, nz, fr (code pays fourni par la source)

Quantifying sleep wake rhythms in the hospital environment with digital technologies

Carsten Skarke, Nadim El Jamal, Michael V. Genuardi, Thomas G. Brooks et autres

Postoperative clinical care is prone to circadian desynchronization that may influence health outcomes. In an exploratory, feasibility-oriented and signal-exploration effort, we collected 1.8 million data points using 11 remote sensors during preoperative, in-hospital and post-discharge settings in 13 elective cardiac surgery patients …

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RACGAP1 as a Circulating Biomarker of Atrial Fibrillation in Heart Failure: A Dual-Cohort Proteomic Study

Amen Bekele Zelleke, Joe David Azzo, Jonathan D. Moreno, Douglas L. Mann et autres

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Large-Scale Proteomic Profiling of Incident Heart Failure and Its Subtypes in Older Adults

Joyce Nyaucha Njoroge, Sandra Sanders van Wijk, Thomas R. Austin, Jennifer A. Brody et autres

BACKGROUND: Heart failure (HF) and its main subtypes, heart failure with preserved ejection fraction (HFpEF) and heart failure with reduced ejection fraction (HFrEF), impose an enormous health burden on elders. Assessment of the circulating proteome to illuminate pathogenesis could open new opportunities …

us, nl, tw, gb, ch, is (code pays fourni par la source)

Dephospho-Uncarboxylated Matrix Gla-Protein Is Associated With Adverse Outcomes in Heart Failure

Mahesh K. Vidula, Leon J. Schurgers, Lei Zhao, Marie‐Joe Dib et autres

BACKGROUND: MGP (matrix Gla-protein), a known inhibitor of vascular calcification, becomes biologically active by vitamin K–dependent carboxylation. Circulating levels of dpucMGP (dephospho-uncarboxylated matrix Gla-protein), the inactive form of MGP, have been associated with large artery stiffening and reduced skeletal muscle mass in …

us, nl, be, sg, nz (code pays fourni par la source)

Circulating Proteomic Profiles in Ambulatory Patients With Advanced Stage C2D Heart Failure: Insights From the Registry Evaluation of Vital Information for VADs in Ambulatory Life (REVIVAL) Registry

Douglas L. Mann, Julio A. Chirinos, Jinsheng Yu, Wei Yang et autres

Recent studies underscore the need to identify ambulatory stage C heart failure (HF) patients who, despite receiving guideline-directed therapy (GDMT), experience persistent symptoms and recurrent hospitalization, which is associated with high risk for near-term progression to stage D HF (“C2D” HF) and …

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Polygenic Background and Penetrance of Pathogenic Variants in Hypertrophic and Dilated Cardiomyopathies

Sarah A. Abramowitz, Lily Hoffman‐Andrews, David Y. Zhang, Renae Judy et autres

Importance: Polygenic background modifies variant penetrance in hypertrophic (HCM) and dilated (DCM) cardiomyopathies, diseases with opposing morphologic characteristics and inversely related genetic pathways. Whether polygenic susceptibility for one disease protects against monogenic risk for the other remains uncertain. Objective: To characterize if …

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Author Correction: Common-variant and rare-variant genetic architecture of heart failure across the allele-frequency spectrum

David S.M. Lee, Kathleen M. Cardone, David Zhang, Noah L. Tsao et autres

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