Douglas L. Mann

Clonal Hematopoiesis of Indeterminate Potential Proteomic Risk Score for Predicting Clinical Outcome in Patients With Heart Failure With Preserved Ejection Fraction

Minkwan Kim, Vinayak Subramanian, Hamed Tavolinejad, Mateo Sarmiento Bustamante et autres

BACKGROUND: Clonal hematopoiesis of indeterminate potential (CHIP) is common in heart failure with preserved ejection fraction (HFpEF). However, the proteomic signatures linked to CHIP driver mutations and their prognostic implications in HFpEF remain poorly defined. We aimed to identify plasma protein signatures …

kr, us, sg, nz, be, nl (code pays fourni par la source)

Cardio‐Immunology: Reframing the Pathogenesis of Cardiovascular Disease

Douglas L. Mann

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What E.B. Meant to Me

Douglas L. Mann

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Body Mass Index, Clinical Outcomes, and Mortality in Heart Failure

Nicholas P. Sunderland, Géraldine Asselin, Albert Carl Henry, Christopher P. Nelson et autres

BACKGROUND: Excess adiposity, most commonly indexed through body mass index (BMI), is strongly associated with the development of heart failure (HF). Weight loss therapies improve outcomes in patients with obesity and HF with preserved left ventricular ejection fraction (LVEF), but their effects …

gb, ca, nl, us, se, my, nz, fr (code pays fourni par la source)

RACGAP1 as a Circulating Biomarker of Atrial Fibrillation in Heart Failure: A Dual-Cohort Proteomic Study

Amen Bekele Zelleke, Joe David Azzo, Jonathan D. Moreno, Douglas L. Mann et autres

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Michael R. Bristow: The Consummate Physician-Scientist of This Generation

Arthur M. Feldman, Douglas L. Mann

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In Memoriam: Michael R. Bristow, MD, PhD

Mona Fiuzat, CHRISTOPHER M. O'CONNOR, Douglas L. Mann

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Michael R. Bristow, MD, PhD

Douglas L. Mann, Arthur M. Feldman, Mona Fiuzat, Chrisopher M. O’Connor et autres

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Cardio-Hematopoietic Axis in Cardiac Injury and Repair: From Adaptation to Maladaptation

Douglas L. Mann, Andrew I. Schafer

The cardiovascular and hematopoietic systems are functionally interconnected through the cardio-hematopoietic axis, a dynamic signaling network that governs hematopoietic responses following cardiac injury. Traditionally viewed primarily as a unidirectional pathway in which cardiac damage mobilizes bone marrow-derived cells to facilitate myocardial repair, …

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Proteome-Wide Genetic Investigation of Kidney Function in Heart Failure With Preserved Ejection Fraction

Karim Kohansal Vajargah, Marie‐Joe Dib, Hamed Tavolinejad, Payman L. Zamani et autres

ir, us, nz, be, nl, gb (code pays fourni par la source)

Abstract 4360121: PD-1-deficient Dendritic Cells Show Reduced Lysosomal Activity in a Model of Immune Checkpoint Inhibitor-associated Myocarditis

Kenji Rowel Q. Lim, Douglas L. Mann, Abhinav Diwan

Introduction: Although immune checkpoint inhibitors (ICIs) have transformed cancer therapy, they can cause immune-related adverse effects, including ICI myocarditis, a potentially fatal form of inflammation-induced cardiac injury. What triggers autoreactive T cell activation in patients treated with ICIs remains unclear. Dendritic cells …

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Bringing Advanced Heart Failure Therapies to Veterans

Jonathan D. Moreno, Douglas L. Mann

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