Jizhi Liang

Flexible MEMS Neural Interface for Long-Term Minimally Invasive Deep-Brain Recording Within CSF Environments

Jizhi Liang, Xiaoyu Li, Xiner Wang, Tiger H. Tao et autres

This paper presents a flexible deep-brain neural interface fabricated using MEMS technology, consisting of a deformable microelectrode array mechanically coupled to a shape-memory silk fibroin scaffold. The device is delivered to the lateral ventricle via standard neurosurgical catheters and, upon exposure to …

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Chronically Stable, High‐Resolution Micro‐Electrocorticographic Brain‐Computer Interfaces for Real‐Time Motor Decoding (Adv. Sci. 45/2025)

Xiner Wang, Jizhi Liang, Yang Liu, Xingchen Ran et autres

µECoG BCI with Universal OS for Real-Time Motor Imagery Decoding In their Research Article (DOI: 10.1002/advs.202506663), Zhitao Zhou, Zehan Wu, Tiger H. Tao, and co-workers present a flexible high-density µECoG BCI and paired universal operating system, achieving 203-day stable real-time motor decoding …

Silk-enabled conformal intraventricular interfaces for minimally invasive neural recordings

Jizhi Liang, Xiner Wang, Zhaohan Chen, Xiaoling Wei et autres

Flexible neural interfaces capable of monitoring subcortical neuronal activity facilitate the study of deep brain neural circuits and their interactions with the cortex. However, there exists a paucity of translational tools for interfacing subcortical nuclei surfaces within the intraventricular cerebrospinal fluid. Here, …

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Chronically Stable, High‐Resolution Micro‐Electrocorticographic Brain‐Computer Interfaces for Real‐Time Motor Decoding

Xiner Wang, Jizhi Liang, Yang Liu, Xingchen Ran et autres

Brain-computer interfaces (BCIs) enable communication between individuals and computers or other assistive devices by decoding brain activity, thereby reconstructing speech and motor functions for patients with neurological disorders. This study presents a high-resolution micro-electrocorticography (µECoG) BCI based on a flexible, high-density µECoG …

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Silk-Based Self-Unfolding Electrode Array for Minimally-invasive Large-Scale Deep Brain Activity Monitoring

Jizhi Liang, Xiner Wang, Zhaohan Chen, Xiaoling Wei et autres

This paper reports a silk-based deep-brain neural interface featuring a deformable microelectrode array paired with a silk scaffold, designed to deployed and proper functioning in the dynamic milieu of the cerebrospinal fluid. The whole microelectrode array can be minimally invasively implanted into …

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A Mems-Based Flexible Bidirectional Multiregion Neural Interface for Olfactory Augmentation

Jizhi Liang, Hailang He, Yuxin Liu, Xiaoling Wei et autres

This paper reports a flexible and bidirectional olfactory neural interface based on microelectromechanical systems fabrication process and the demonstrations of cross-regional synchronous recording and olfactory augmentation on free-moving mice. With overall 4-μm-thick microelectrodes and a compact headstage mounted on the skull, it …

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Gustatory interface for operative assessment and taste decoding in patients with tongue cancer

Xiner Wang, Guo Bai, Jizhi Liang, Qianyang Xie et autres

Taste, a pivotal sense modality, plays a fundamental role in discerning flavors and evaluating the potential harm of food, thereby contributing to human survival, physical and mental health. Patients with tongue cancer may experience a loss of taste following extensive surgical resection …

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Silk-Enabled Foldable and Conformal Neural Interface with In-Plane Shielding for High-Quality Electrophysiological Recordings

Jizhi Liang, Zhaohan Chen, Xiner Wang, Feihong Xu et autres

This paper reports a flexible, foldable and conformal neural interface with in-plane shielding fabricated by MEMS process. Based on the tailored planar pattern derived from hemisphere, it can conformally attach to curved surfaces with featured radiuses of typical intracranial space-occupying tumors or …

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Real-Time Functional Brain Mapping Based on High-Channel-Count, Ultra-Conformal Neural Interface

Xiner Wang, Zhaohan Chen, Jizhi Liang, Xiaoling Wei et autres

We report a real-time functional brain mapping technique based on high-channel-count, ultra-conformal electrocorticographic (ECoG) electrodes. The MEMSbased 64-channel ECoG electrodes can well conform to the curvilinear surface of the cortex, thus showing good neural signal recording quality. This neural interface was applied …

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A silk-based self-adaptive flexible opto-electro neural probe

Yu Zhou, Chi Gu, Jizhi Liang, Bohan Zhang et autres

The combination of optogenetics and electrophysiological recording enables high-precision bidirectional interactions between neural interfaces and neural circuits, which provides a promising approach for the study of progressive neurophysiological phenomena. Opto-electrophysiological neural probes with sufficient flexibility and biocompatibility are desirable to match the …

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Post-Operative Assessment of Tongue Reconstruction Using Ultra-Conformal, High Density Tongue Electrodes

Jizhi Liang, Guo Bai, Zhaohan Chen, Feihong Xu et autres

We report an ultra-conformal and high-density surface tongue electrodes with the overall thickness of 7 µm using MEMS fabrication process. Based on the device, high quality electrical signals of the whole tongue dorsum can be monitored continuously, without bringing pain to patients …

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