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Miguel Martín‐Aragón Baudel, Hannah Voorhees, Arsalan U. Syed, Maryann K. Ferrara et autres
Abstract L‐type Ca V 1.2 channels are key regulators of cellular function in diverse cell types, controlling processes that range from gene expression to muscle contraction. In arterial myocytes, Ca V 1.2 channels traffic to the plasma membrane and assemble into clusters …
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Hannah M. Voorhees, Jade L. Taylor, Maartje Westhoff, Johannes Wilhelm Hell et autres
Voltage-gated L-type channels, Ca V 1.2, drive gene expression, excitability, and excitationcontraction. 1 As central mediators of cardiovascular physiology, Ca V 1.2 channels are key therapeutic targets in hypertension, arrhythmias, and heart failure, establishing calcium channel blockers among the most prescribed cardiovascular …
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Ian Salveson, David E. Anderson, Aritra Bej, Madeline Nieves‐Cintrón et autres
The L-type voltage-gated Ca 2+ channel (Ca V 1.2) controls gene expression, cardiac function, and neuronal excitability. Mutations in Ca V 1.2 that disrupt channel function are implicated in cardiac arrhythmias, vascular dysfunction, Timothy Syndrome, and epilepsy. Calcium-binding protein 1 (CaBP1) binds …
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Christiane Huhn, Clémence Mille, Sheng‐Yang Ho, Felix P. Lützenkirchen et autres
Direct visualization of postsynaptic scaffolds in living neurons is essential for dissecting synaptic dynamics and plasticity. Existing methods for live synapse visualization have major constraints, relying on genetic engineering or multistep application of live-cell incompatible antibodies or nanobodies. Available affinity probes and …
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Christiane Huhn, Clémence Mille, Sheng‐Yang Ho, Felix Lützenkirchen et autres
ZUSAMMENFASSUNG Die direkte Visualisierung postsynaptischer Gerüstproteine in lebenden Neuronen ist eine entscheidende Voraussetzung für die Untersuchung synaptischer Dynamik und Plastizität. Bisherige Methoden zur Live‐Synapsenbildgebung sind jedoch stark eingeschränkt: Sie erfordern genetische Manipulationen oder beruhen auf mehrstufigen Protokollen mit für Live‐Cell Imaging ungeeigneten …
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Aritra Bej, M. Quincy Erickson-Oberg, Aparna Nigam, Isaac Furay Yu et autres
The synaptic plasticity mechanisms that are thought to underlie learning and memory require Ca 2+ influx mediated by N -methyl-D-aspartate receptors (NMDARs) composed of glycine-binding GluN1 and glutamate-binding GluN2 subunits. Calmodulin (CaM) binding to the cytosolic regions in both GluN1 (residues 841-865, …
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Kwun Nok Mimi Man, Sarah L. S. Rougé, Ruben A. Berumen, Ariel A. Jacobi et autres
Dopamine drives the neuronal activity and synaptic plasticity required for various forms of learning. It supports short-term working memory through activation of the D 1 -like dopamine receptors D 1 and D 5 . Here, we found that the L-type Ca 2+ …
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Olivia R. Buonarati, Peter B. Henderson, Geoffrey G. Murphy, Mary C. Horne et autres
Background : The L-type Ca2+ channel Cav1.2 is a prominent regulator of neuronal excitability, synaptic plasticity, and gene expression. The central element of Cav1.2 is the pore-forming α 1 1.2 subunit. It exists in two major size forms, whose molecular masses have …
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Ivar S. Stein, Michaela S. Donaldson, Johannes Wilhelm Hell
Learning and memory as well as long-term potentiation (LTP) depend on Ca 2+ influx through the NMDA-type glutamate receptor (NMDAR) and the resulting activation of the Ca 2+ and calmodulin-dependent protein kinase (CaMKII). Ca 2+ influx via the NMDAR triggers CaMKII binding …
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Xiaomin Xing, Erik A Hammes, Zoila M. Estrada‐Tobar, Karam Kim et autres
Signaling by norepinephrine (NE) via adrenergic receptors (ARs) mediates attention, yet the underlying molecular mechanisms are largely unknown. AMPA receptors (AMPARs) form a complex with β 2 ARs, G s , adenylyl cyclase, and protein kinase A (PKA) to augment AMPAR phosphorylation …
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Deepak Kumar Yadav, Effibe O. Ahoulou, David E. Anderson, Aritra Bej et autres
The L-type voltage-gated Ca 2+ channel (Ca V 1.2) controls gene expression, cardiac contraction, and neuronal activity. The C-terminal cytosolic region of the Ca V 1.2 alpha subunit (α1C) contains two domains known as proximal and distal C-terminal regulatory domains (PCRD and …
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Paul B. Bernard, Anna M. Castano, Olivia R. Buonarati, Chad R. Camp et autres
We probed the dependence of metabotropic glutamate receptor dependent long-term depression (mGluR-LTD) on L-type voltage gated calcium channels (LTCCs). In prior work, we found that in a rat model of early life seizures (ELS), exaggerated mGluR-LTD was partly mediated by LTCCs and …
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