Prediction of postoperative delirium in older adults from preoperative cognition and occipital alpha power from resting-state electroencephalogram
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Le résumé fourni par la source
BACKGROUND: Postoperative delirium is the most common complication following surgery amongst older adults, and has been consistently associated with increased mortality and morbidity, cognitive decline, loss of independence and increased health-care costs. We sought to identify preoperative predictors that could identify individuals at high risk for postoperative delirium, which could guide clinical decision-making and enable targeted interventions to potentially decrease delirium incidence and postoperative delirium-related complications. METHODS: Preoperative resting-state electroencephalograms (EEGs) and the Montreal Cognitive Assessment were collected from a prospective observational cohort of 85 older adults (12 cases of delirium) undergoing elective surgery. Four machine learning models were tested and the model with the highest f1-score was subsequently validated in an independent, prospective cohort of 51 older adults (6 cases of delirium) undergoing elective surgery. RESULTS: Occipital alpha powers have higher f1-score (0.57 ± 0.07) than frontal alpha powers (0.47 ± 0.07), EEG spectral slowing (0.48 ± 0.08), or modelling of EEG power spectral density into periodic and aperiodic components (0.44 ± 0.09) in the training cohort. Occipital alpha powers plus cognitive scores were able to predict postoperative delirium with area under the receiver operating characteristic curve (AUC) (0.94, 95% CI: [0.86-0.99]), sensitivity (0.83, 95% CI: [0.50-1.00]) and specificity (0.91, 95% CI: [0.82-0.98]) in the validation cohort, and outperformed models incorporating occipital alpha powers alone or cognitive scores alone. CONCLUSIONS: Whilst the sample size is small and findings require confirmation in larger studies, our results suggest that the thalamocortical circuit exhibits different EEG patterns under stressors, with occipital alpha powers potentially reflecting baseline vulnerabilities.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Prediction of postoperative delirium in older adults from preoperative cognition and occipital alpha power from resting-state electroencephalogram
- Date Crossref
- 30/10/2025
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Berenson Allen Center for Noninvasive Brain Stimulation pays non établi dans la noticeStructure de recherche
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University of Helsinki Department of Education pays non établi dans la noticeUniversité ou école supérieure
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VA Palo Alto Health Care System pays non établi dans la noticeÉtablissement de santé
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Stanford Health Care pays non établi dans la noticeÉtablissement de santé
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Stanford Medicine pays non établi dans la noticeÉtablissement de santé
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Beth Israel Deaconess Medical Center Neurology pays non établi dans la noticeÉtablissement de santé
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Brigham and Women's Hospital Radiology pays non établi dans la noticeÉtablissement de santé
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Massachusetts General Hospital Neurology pays non établi dans la noticeÉtablissement de santé
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Brown University Psychiatry and Human Behavior pays non établi dans la noticeUniversité ou école supérieure
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Blackstone (United States) pays non établi dans la noticeEntreprise
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Hebrew SeniorLife pays non établi dans la noticeOrganisation à but non lucratif
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Marcus Foundation pays non établi dans la noticeOrganisation à but non lucratif
Berenson Allen Center for Noninvasive Brain Stimulation, Department of Education — University of Helsinki et VA Palo Alto Health Care System, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.