Konstantin Lutz

CCL17 Promotes Colitis-Associated Tumorigenesis Dependent on the Microbiota

Rebecca Metzger, Lis Winter, Nassim Bouznad, Debora Garzetti et autres

Colorectal cancer is one of the most common cancers and a major cause of mortality. Proinflammatory and antitumor immune responses play critical roles in colitis-associated colon cancer. CCL17, a chemokine of the C-C family and ligand for CCR4, is expressed by intestinal …

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Ly6D+Siglec-H+ precursors contribute to conventional dendritic cells via a Zbtb46+Ly6D+ intermediary stage

Konstantin Lutz, Andrea Musumeci, Christopher Sie, Ezgi Dursun et autres

Abstract Plasmacytoid and conventional dendritic cells (pDC and cDC) are generated from progenitor cells in the bone marrow and commitment to pDCs or cDC subtypes may occur in earlier and later progenitor stages. Cells within the CD11c + MHCII −/lo Siglec-H + …

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Binding of phosphatidylserine‐positive microparticles by PBMCs classifies disease severity in COVID‐19 patients

Lisa Rausch, Konstantin Lutz, Martina Schifferer, Elena Winheim et autres

Abstract Infection with SARS‐CoV‐2 is associated with thromboinflammation, involving thrombotic and inflammatory responses, in many COVID‐19 patients. In addition, immune dysfunction occurs in patients characterised by T cell exhaustion and severe lymphopenia. We investigated the distribution of phosphatidylserine (PS), a marker of …

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Impaired function and delayed regeneration of dendritic cells in COVID-19

Elena Winheim, Linus Rinke, Konstantin Lutz, Anna Reischer et autres

Disease manifestations in COVID-19 range from mild to severe illness associated with a dysregulated innate immune response. Alterations in function and regeneration of dendritic cells (DCs) and monocytes may contribute to immunopathology and influence adaptive immune responses in COVID-19 patients. We analyzed …

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Binding of phosphatidylserine-positive microparticles by PBMCs classifies disease severity in COVID-19 patients

Lisa Rausch, Konstantin Lutz, Martina Schifferer, Elena Winheim et autres

SUMMARY Infection with SARS-CoV-2 is associated with thromboinflammation, involving thrombotic and inflammatory responses, in many COVID-19 patients. In addition, immune dysfunction occurs in patients characterized by T cell exhaustion and severe lymphopenia. We investigated the distribution of phosphatidylserine (PS), a marker of …

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Impaired function and delayed regeneration of dendritic cells in COVID-19

Elena Winheim, Linus Rinke, Konstantin Lutz, Anna Reischer et autres

Abstract Disease manifestations in COVID-19 range from mild to severe illness associated with a dysregulated innate immune response. Alterations in function and regeneration of dendritic cells (DC) and monocytes may contribute to immunopathology and influence adaptive immune responses in COVID-19 patients. We …

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Profound phenotype alteration and delayed regeneration of circulating antigen presenting cells in COVID-19

Elena Winheim, Linus Rinke, Konstantin Lutz, Anna Reischer et autres

Abstract Disease manifestations in COVID-19 range from mild symptoms to severe/critical illness with lung inflammation, hypercoagulation and cardiovascular complications, which may be caused by a dysregulated innate immune response. Antigen presenting cells may contribute to the inflammatory response and shape the adaptive …

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pDC_precursor_scvelo.h5ad

Konstantin Lutz, Anne Krug, Andrea Musumeci

pDC, Siglec-H- pre-cDC, CD115+ CDP, CD127+ CLP, Ly6D+ lymphoid progenitors, Ly6D+ Siglec-H+ lymphoid progenitors, lo-lo and lo-hi were sorted one cell per well across nine 96-well plates, 96 cells per population, with each population spread across two plates. Using shared HVGs for …

What Makes a pDC: Recent Advances in Understanding Plasmacytoid DC Development and Heterogeneity

Andrea Musumeci, Konstantin Lutz, Elena Winheim, Anne Krug

Dendritic cells (DCs) are professional antigen presenting cells (APCs) that originate in the bone marrow and are continuously replenished from hematopoietic progenitor cells. Conventional DCs (cDCs) and plasmacytoid DCs (pDCs) are distinguished by morphology and function, and can be easily discriminated by …

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Aquaporin 11, a regulator of water efflux at retinal Müller glial cell surface decreases concomitant with immune-mediated gliosis

Cornelia A. Deeg, Barbara Amann, Konstantin Lutz, Sieglinde Hirmer et autres

BACKGROUND: Müller glial cells are important regulators of physiological function of retina. In a model disease of retinal inflammation and spontaneous recurrent uveitis in horses (ERU), we could show that retinal Müller glial cells significantly change potassium and water channel protein expression …

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Ly6D+Siglec-H+ precursors contribute to conventional dendritic cells via a Zbtb46+Ly6D+ intermediary stage

Konstantin Lutz, Andrea Musumeci, Christopher Sie, Ezgi Dursun et autres

Abstract Plasmacytoid and conventional dendritic cells (pDC and cDC) are generated from progenitor cells in the bone marrow and commitment to pDCs or cDC subtypes may occur in earlier and later progenitor stages. Cells within the CD11c+MHCII−/loSiglec-H+CCR9lo DC precursor fraction of the …