Maria A. Katsianou

Polycomb Repressive Complex 2 (PRC2): A Context-Dependent Epigenetic Regulator of Brain Aging

Maria A. Katsianou, Eleni‐Kyriaki Vetsika, Mariam Markouli, Christina Piperi et autres

Brain aging is characterized by extensive and dynamic epigenetic changes that reshape chromatin architecture and influence gene regulatory networks, leading to deregulation of transcriptional programs essential for neuronal survival, synaptic plasticity, and cognitive function. Emerging studies highlight the pivotal regulatory role of …

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The Role of AP-1 in Cancer: Regulation, Tumor Microenvironment and Therapeutic Targeting

Maria A. Katsianou, Dimitrios Vrachas, Christos Adamopoulos

The activator protein-1 (AP-1) transcription factor is a regulatory dimeric transcription factor complex, that responds to a wide range of intracellular and extracellular stimuli and controls gene expression involved in tumor initiation and progression. Comprised primarily of members of Jun and Fos …

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Epigenetic Regulation of RUNX2 in Bone Mechanobiology

Maria A. Katsianou, Antonios N. Gargalionis, Athanasios G. Papavassiliou, Efthimia K. Basdra

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The Critical Role of Transcription Factor RUNX2 in Bone Mechanobiology

Maria A. Katsianou, Antonios N. Gargalionis, Kostas A. Papavassiliou, Angeliki Margoni et autres

Mechanobiology plays a pivotal role in skeletal development and bone remodeling. Mechanical signals such as matrix stiffness, fluid shear stress, and hydrostatic pressure activate the Runt-related transcription factor 2 (RUNX2) bone-specific transcription factor through pathways including the mitogen-activated protein kinase (MAPK) signaling …

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Epigenetic Modifications in Osteosarcoma: Mechanisms and Therapeutic Strategies

Maria A. Katsianou, Dimitrios Andreou, Penelope Korkolopoulou, Eleni‐Kyriaki Vetsika et autres

Osteosarcoma (OS), the most common primary bone cancer of mesenchymal origin in children and young adolescents, remains a challenge due to metastasis and resistance to chemotherapy. It displays severe aneuploidy and a high mutation frequency which drive tumor initiation and progression; however, …

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Pediatric gliomas immunity challenges and immunotherapy advances

Eleni‐Kyriaki Vetsika, Maria A. Katsianou, Panagiotis Sarantis, Kostas Palamaris et autres

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Polycystin‐1 regulates cell proliferation and migration through AKT/mTORC2 pathway in a human craniosynostosis cell model

Maria A. Katsianou, Kostas A. Papavassiliou, Antonios N. Gargalionis, George Agrogiannis et autres

Craniosynostosis is the premature fusion of skull sutures and has a severe pathological impact on childrens' life. Mechanical forces are capable of triggering biological responses in bone cells and regulate osteoblastogenesis in cranial sutures, leading to premature closure. The mechanosensitive proteins polycystin-1 …

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The role of polycystin 1 and 2 in cranial suture fusion

Maria A. Katsianou

Η κρανιοσυνοστέωση αναφέρεται στην πρόωρη σύγκλιση μίας ή περισσοτέρων κρανιακών ραφών που οδηγούν σε παραμορφώσεις του κρανίου και στον περιορισμό της ανάπτυξης του εγκεφάλου. Είναι η δεύτερη συχνότερη, κλινικά σημαντική κρανιοπροσωπική διαταραχή και, μέχρι σήμερα, η αντιμετώπιση αυτής της ασθένειας περιορίζεται σε …

The role of transient receptor potential polycystin channels in bone diseases

Maria A. Katsianou, Foteini G. Skondra, Antonios N. Gargalionis, Christina Piperi et autres

Transient receptor potential (TRP) channels are cation channels which act as molecular sensors that enable cells to detect and respond to a plethora of mechanical and environmental cues. TRPs are involved in various physiological processes, such as mechanosensation, non-inception and thermosensation, while …

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Continuous hydrostatic pressure induces differentiation phenomena in chondrocytes mediated by changes in polycystins, SOX9, and RUNX2

Konstantinos Karamesinis, Anastasia Spyropoulou, Georgia Dalagiorgou, Maria A. Katsianou et autres

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Signaling mechanisms implicated in cranial sutures pathophysiology: Craniosynostosis

Maria A. Katsianou, Christos Adamopoulos, Heleni Vastardis, Efthimia K. Basdra

Normal extension and skull expansion is a synchronized process that prevails along the osteogenic intersections of the cranial sutures. Cranial sutures operate as bone growth sites allowing swift bone generation at the edges of the bone fronts while they remain patent. Premature …

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Investigation of the potential link between mechanosensory proteins PC1/PC2 and craniosynostosis

Maria A. Katsianou, Christina Piperi, Penelope Korkolopoulou, Marios Themistocleous et autres

associated with an elevated expression of the osteoblastic marker RUNX2 and a lower expression of the chondrocytic marker SOX-9 C) Immunohistochemical analysis showed nuclear expression of PC1/PC2 in SAG sutures: Investigation of the potential link between mechanosensory proteins PC1/PC2 and Craniosynostosis

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