Penelope Korkolopoulou

Antitumour Effects of β-Blockers: A Narrative Review of the Literature

Dimitra Melissaridou, Olga D. Savvidou, Ioanna Lianou, Angelos Kaspiris et autres

Beta (β)-adrenergic receptors are Gs-protein-coupled receptors with many physiological actions but are also expressed in various types of cancers. Preclinical in vitro and in vivo research studies demonstrated that the antagonism of β-adrenergic receptor signalling by β-blockers inhibits multiple cellular processes involved …

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SHP-2 Expression Is a Positive Prognostic Biomarker in Non-Small-Cell Lung Carcinoma: Association with KRAS Mutation and Prolonged Survival

Konstantinos Stamopoulos, Georgios Pilichos, Eleni Karatrasoglou, Penelope Korkolopoulou et autres

Background/Objectives: Lung cancer tumors are the most frequent malignant tumors and the primary cause of cancer-related deaths. Despite the improvement in survival related to the implementation of immunotherapy, a significant proportion of patients fail to demonstrate satisfactory response. As a result, the …

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Clonal B-Cell Lymphocytosis of Marginal Zone Origin: Presenting Features, Clinical Evolution and Prognostic Factors

Sotirios Sachanas, Gerassimos Pangalis, Christina Kalpadakis, Theodoros P. Vassilakopoulos et autres

Background/Objective: During the last two decades, several cases presenting with circulating clonal B-cells with features consistent with possible marginal zone (MZ) derivation have been described under different terminologies. The present study aims to shed more light onto the main disease characteristics and …

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Real World Data from Patients With Osteosarcoma Treated in 8 Medical Centers in Greece: Ninety Percent or Greater Tumor Necrosis Is Associated With Disease‐free Survival

Anastasios Kyriazoglou, Myrto Moutafi, Ioannis Kotsantis, P. Antonopoulou et autres

Background/Aim: Advanced osteosarcomas tend to have poor prognosis with limited therapeutic options beyond first-line therapy. This retrospective, multi-institutional study aimed to evaluate the association between histological response to chemotherapy and survival outcomes, as well as the influence of sex, tumor size, location, …

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SUV39H1 regulates progression of pediatric diffuse high-grade gliomas through modulation of β-catenin/TCF4 levels

Αλεξία Κλώνου, Angeliki-Ioanna Giannopoulou, Christos Adamopoulos, Dimitrios S. Kanakoglou et autres

Pediatric diffuse high-grade gliomas (pHGGs) are heterogeneous and infiltrative tumors with poor prognosis. Recent molecular characterization of pHGGs has revealed an altered epigenetic profile with aberrant post-translational modifications and increased histone 3 lysine 9 trimethylation (H3K9) to be implicated in their pathology. …

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LINE-1 hypomethylation in cell-free DNA of high-grade glioma patients correlates with tissue levels and is associated with reduced DNMT1 and H4K20me3 expression

Angeliki-Ioanna Giannopoulou, Panagiotis Skouras, Panagiotis Sarantis, Alkinoos A Armoundas et autres

Gliomas exhibit diverse genetic, molecular, and histological profiles with limited liquid biopsy biomarkers. Loss of Long Interspersed Nuclear Element-1 (LINE-1) methylation confers to genomic instability and tumorigenesis, primarily mediated by DNA methyltransferase 1 (DNMT1) through interaction with histone H4 lysine 20 trimethylation …

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Incidental Finding of an Inflammatory Myofibroblastic Tumor of the Urinary Bladder: A Case Report

Konstantinos Douroumis, Penelope Korkolopoulou, Afroditi Nonni, Dionysios Mitropoulos et autres

Bladder inflammatory myofibroblastic tumors (IMTs) are rare lesions with intermediate malignant potential and unclear management guidelines. We report the case of a 61-year-old male presenting with lower urinary tract symptoms and a bladder mass. Histology revealed spindle cells with mild atypia and …

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Epigenetic Modifications in Osteosarcoma: Mechanisms and Therapeutic Strategies

Maria A. Katsianou, Dimitrios Andreou, Penelope Korkolopoulou, Eleni‐Kyriaki Vetsika et autres

Osteosarcoma (OS), the most common primary bone cancer of mesenchymal origin in children and young adolescents, remains a challenge due to metastasis and resistance to chemotherapy. It displays severe aneuploidy and a high mutation frequency which drive tumor initiation and progression; however, …

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Primary Breast Lymphoma: A Rare Presentation of Diffuse Large B-Cell Lymphoma, Germinal Center B-Cell Subtype (DLBCL-GCB)

Dimosthenis Chrysikos, Eirini Livieratou, Stavroula Giannouli, Anna Kontogeorgou et autres

Primary breast lymphoma (PBL) is a rare type of extranodal lymphoma, accounting for only 0.5% of all breast malignancies. Diffuse large B-cell lymphoma (DLBCL) is the most common histological subtype of PBL, with the germinal center B-cell (GCB) subtype being an exceptionally …

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SUV39H1 regulates progression of pediatric diffuse high-grade gliomas through modulation of β-catenin/TCF4 levels

Αλεξία Κλώνου, Angeliki-Ioanna Giannopoulou, Christos Adamopoulos, Dimitrios S. Kanakoglou et autres

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Integrating molecular classification in adenoid cystic carcinoma of the head and neck: The experience from four tertiary centers in Greece

Panagiota Economopoulou, Theodoros Pantazopoulos, Danai Leventakou, Nektarios Koufopoulos et autres

BACKGROUND: Recently, a molecular characterization of adenoid cystic carcinoma (ACC) has been proposed, based on upregulation of c-Myc, a proto-oncogene involved in carcinogenesis, and p63, a transcription factor of the p53 gene family. The aim of this study was to evaluate c-Myc …

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Exploring the Interaction of Tumor-Derived Exosomes and Mesenchymal Stem Cells in Tumor Biology

K. Papadopoulos, Penelope Korkolopoulou, Christina Piperi

Exosomes are actively produced extracellular vesicles, released from different cell types, that exert important regulatory roles in vital cellular functions. Tumor-derived exosomes (TDEs) have received increasing attention because they enable intercellular communication between the neoplastic and non-neoplastic cells present in the microenvironment …

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