Juan Lv

Correlation between calcium levels and coronary microvascular disease in high-altitude environments: nested case-control study

Xiyang Rao, Xiao Chen, Wentao Zhang, Juan Lv et autres

Background Coronary microvascular disease (CMVD) is an emerging concern under high-altitude hypoxia, but data on modifiable correlates are scarce. Serum calcium regulates vascular tone and coagulation, making it a plausible candidate marker. However, its association with CMVD at high altitude has not …

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Serum potassium and high-altitude coronary microvascular disease: a propensity score matched analysis revealing a linear dose-response relationship

Yu Chen, Ming Shen, Xi Zhang, Yong Ren et autres

Background: High-altitude exposure precipitates coronary microvascular disease (CMVD), a pathology linked to hypoxia-induced ion channel dysfunction. However, prior observational evidence connecting serum potassium to CMVD resilience is limited by residual confounding, and the precise dose-response trajectory remains unmapped. This study utilized Propensity …

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Prediction of pulmonary tuberculosis case trends among older adults in Chongqing based on time series models

Bojie Gao, Shanrong Huang, Jie Luo, Wenping Liao et autres

Background: Tuberculosis is a major global public health issue. Older adult individuals, due to factors like immunosenescence and comorbidities, are at high risk for TB. Chongqing's significant aging population poses severe challenges for TB control in this group. Objective: This study is …

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Applications of bone regenerative medicine in the foot and ankle: mechanisms, technologies, and therapeutic advances

Yijie Li, Tianqi Wang, Zhuo Zhao, Li Wang et autres

Background: Foot and ankle diseases significantly impact quality of life, with regenerative medicine emerging as a promising approach. A comprehensive evaluation of both efficacy and safety is paramount for its clinical translation. Methods: A comprehensive literature search was conducted in PubMed using …

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Differential expression of platelet CD147 in moderate altitude conditions: implications for coronary plaque stability assessment

Yu Chen, Si Lu, Chun-Ping Bao, Yong Ren et autres

Background: As a major contributor to global death rates, coronary heart disease (CHD) remains critical. This investigation examines CD147's utility for assessing plaque characteristics among CHD patients, with a focus on moderate altitude populations. Methods: Initially, high-throughput sequencing was performed on platelet …

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Survey on nursing caring behaviors needs of older adult inpatients based on Kano model and analysis of factors: A cross-sectional study

J Zhang, Juan Lv, Hongxiu Chen, Xiuying Hu

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Secreted frizzled-related protein 4 (sFRP4) in cancer – Dual roles in tumorigenesis and therapeutic potential: A review

Yu Jiang, Luyao Wang, Y. Li, Juan Liu et autres

Secreted Frizzled-Related Protein 4 (sFRP4), the largest member of the Secreted Frizzled-Related Protein (sFRP) family, contains two functional domains: a cysteine-rich domain (CRD) homologous to the Wnt-binding region of Frizzled (FZD) receptors and a netrin-like (NTR) domain structurally similar to axonal guidance …

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Inverse association between pre-high-altitude potassium levels and coronary microvascular disease at high altitude: a case-control study

Yu Chen, Yongcheng Ren, Xin Zhang, Wenxia Zhou et autres

Background and Objectives: High-altitude hypoxia is known to impair cardiac microvascular function, a pathophysiological state recognized as coronary microvascular disease (CMVD). This study aimed to investigate the independent association between serum potassium levels and the risk of developing CMVD, after controlling for …

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Effects of belimumab on peripheral blood Breg cells and cytokines in childhood systemic lupus erythematosus

Qianqian Peng, Ruifeng Zhang, Shan Qiu, Tingting Yuan et autres

To evaluate the therapeutic effectiveness of belimumab (BLM) in childhood systemic lupus erythematosus (cSLE) by analyzing peripheral blood Breg cell subsets and related cytokines at multiple time points post-treatment, compared with conventional therapy. From January 2023 to August 2023, 36 cSLE patients …

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LncRNA ABHD11-AS1 Elevates CALM2 to Promote Metastasis of Thyroid Cancer Through Sponging miR-876-5p

Juan Lv, Fukun Chen, Ling Lv, Lu Zhang et autres

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Immunological profile of lactate metabolism-related genes in Psoriasis a comprehensive analysis based on bulk and single-cell RNA sequencing data

Siyu Liu, Juan Lv, F. Li, Yixuan Zhang

Psoriasis (Pso) is a chronic erythema squamous disease often accompanied by metabolic abnormalities. Disturbances in lactate metabolism have been observed in the skin of patients with Pso, but the role of lactate metabolism in the pathogenesis of Pso remains unclear. To identify …

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The quenching-based enhancement on the strong metal-support interaction and pore structure of Ni-CaO for efficient CO2 capture and in-situ conversion

Xuelin Chen, Jinxia Quan, Hailing Yang, Yiyun Chen et autres

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