Differential expression of platelet CD147 in moderate altitude conditions: implications for coronary plaque stability assessment
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Le résumé fourni par la source
Background: As a major contributor to global death rates, coronary heart disease (CHD) remains critical. This investigation examines CD147's utility for assessing plaque characteristics among CHD patients, with a focus on moderate altitude populations. Methods: Initially, high-throughput sequencing was performed on platelet samples obtained from three individuals with stable angina (SA) and three with unstable angina (UA), serving as the discovery cohort for subsequent bioinformatics analysis. Based on the insights gained from this initial phase, the investigation was extended to a larger cohort comprising 90 SA patients and 90 individuals diagnosed with acute coronary syndrome (ACS). Platelets isolated from these patients underwent flow cytometry analysis for CD147 expression. Furthermore, a logistic regression analysis incorporating traditional CHD risk factors was conducted to determine the odds ratio (OR) for CD147 expression in differentiating between stable and unstable plaques. Results: = 0.002), persisting beyond conventional risk adjustment. Conclusion: This study identifies platelet CD147 as a promising predictor for differentiating plaque stability in CHD under moderate altitude conditions. Our findings suggest that CD147 not only contributes to platelet activation and thrombus formation but may also directly influence plaque stability. The impact of chronic hypoxia and other environmental stressors in moderate altitude regions on CD147 expression provides new insights for risk stratification and targeted therapeutic strategies in altitude-specific populations.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Differential expression of platelet CD147 in moderate altitude conditions: implications for coronary plaque stability assessment
- Date Crossref
- 27/10/2025
- Éditeur
- Frontiers Media SA
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Chinese Academy of Medical Sciences & Peking Union Medical College pays non établi dans la noticeUniversité ou école supérieure
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Kunming Medical University Department of Cardiology pays non établi dans la noticeUniversité ou école supérieure
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Dali University pays non établi dans la noticeUniversité ou école supérieure
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Pingjin Hospital pays non établi dans la noticeÉtablissement de santé
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First Affiliated Hospital of Kunming Medical University pays non établi dans la noticeÉtablissement de santé
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Department of Cardiology pays non établi dans la noticeInstitution
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Department of Clinical Medical College pays non établi dans la noticeUniversité ou école supérieure
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Department of Pulmonary and Critical Care Medicine pays non établi dans la noticeInstitution
Chinese Academy of Medical Sciences & Peking Union Medical College, Department of Cardiology — Kunming Medical University et Dali University, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.