Wolfgang Köenig

Circulating Metabolites Are Biomarker Candidates for Stroke Risk Prediction: Results From the BiomarCaRE Project

Christian Schulte, Francisco Ojeda, Märit Jensen, Ferdinand Seum et autres

BACKGROUND: Stratification of stroke risk remains challenging, but metabolomic profiling offers the potential to detect new biomarkers and to improve early risk assessment of incident stroke. The objective of this study was to evaluate the association between circulating metabolites and the incidence …

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Incident coronary heart disease, residual risk and traditional cardiovascular risk factors in the community: The role of the lipid-inflammatory axis

Natalie Arnold, Christina Magnussen, Jessica Weimann, Alina Goßling et autres

Background and aims : Coronary heart disease (CHD) occurs even in individuals classified as “low-risk” by traditional cardiovascular risk factors (CVRFs). We aimed to investigate whether the combinations of high-sensitivity C-reactive protein (hsCRP), lipoprotein (a) (Lp(a)), or triglycerides (TGs) would modulate relative …

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Inclisiran vs bempedoic acid for low-density lipoprotein cholesterol lowering in high-risk patients: the VICTORION-Challenge trial

Ingo Hilgendorf, Dirk Westermann, Bernd Nowak, Peter Uebel et autres

BACKGROUND AND AIMS: Low-density lipoprotein cholesterol (LDL-C) targets remain unmet in many high-risk atherosclerotic cardiovascular disease (ASCVD) patients on statins (± ezetimibe). VICTORION-Challenge compared inclisiran with bempedoic acid (BPA) for LDL-C lowering and target attainment in these patients, directly. METHODS: In this …

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CLONAL HAEMATOPOIESIS OF INDETERMINATE POTENTIAL AND MORTALITY IN CORONARY ARTERY DISEASE

Moritz von Scheidt, Shaunak Adkar, Johannes Krefting, Gregor Hoermann et autres

IS THE U SHAPED ASSOCIATION WITH TOTAL AND CAUSE SPECIFIC MORTALITY CONSISTENT BETWEEN VARIOUS (APO)LIPOPROTEINS IN THE GENERAL POPULATION?

Natalie Arnold, Jie-sheng Lin, Christa Meisinger, Stefan Blankenberg et autres

REAL-WORLD EFFICACY AND TOLERABILITY OF STATINS IN CHILDREN WITH FAMILIAL HYPERCHOLESTEROLEMIA: INSIGHTS FROM THE VRONI STUDY

R.E. Schmieder, Johannes Krefting, Lea Schlieben, Stefan Arens et autres

THE PEDIATRIC LIPID PROFILE: AGE- AND SEX-SPECIFIC LDL-C DISTRIBUTIONS OF THE POPULATION-BASED VRONI STUDY

Johannes Krefting, R.E. Schmieder, Moritz von Scheidt, Lea Schlieben et autres

COLCHICINE REVERSES INFLAMMATORY SIGNATURES IN CHIP-POSITIVE CORONARY DISEASE: THE COLCHIP TRIAL

Moritz von Scheidt, Marius Schwab, Johannes Krefting, Fabian Starnecker et autres

IMPACT OF MONOGENIC FAMILIAL HYPERCHOLESTEROLEMIA ON CARDIOVASCULAR RISK IN AFFECTED FAMILIES: DATA FROM THE VRONI STUDY

Johannes Krefting, R.E. Schmieder, Stefan Arens, Olga Kordonouri et autres

Plasma infrared molecular fingerprinting stratifies residual risk in coronary artery disease and reflects clonal haematopoiesis-associated biology

Moritz von Scheidt, Tarek Eissa, Johannes Krefting, Christian Frieß et autres

BACKGROUND AND AIMS: Residual cardiovascular risk remains substantial in patients with coronary artery disease (CAD) despite optimal secondary prevention. Clonal haematopoiesis of indeterminate potential (CHIP) contributes causally to this risk but requires sequencing for detection. Plasma infrared molecular fingerprinting (IMF), a spectroscopy-based …

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First count the particles: ApoB, the LDL-C/TC ratio, and the hierarchy of lipid risk assessment

Natalie Arnold, Wolfgang Köenig

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Genetic screening of children for familial hypercholesterolaemia: the VRONI study

Lea D. Schlieben, Raphael S. Schmieder, A L Amosov, Johannes Krefting et autres

BACKGROUND AND AIMS: The role of genetic testing as part of universal screening programmes for familial hypercholesterolaemia (FH) in children is not well defined. Here, a two-step approach to identify children carrying FH-causing variants was investigated. METHODS: In this study from Southern …

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