Sabitha Sasidharan Pillai

Tangier Disease

Sabitha Sasidharan Pillai, Preneet Cheema Brar, Ambika P. Ashraf

PURPOSE OF REVIEW: We describe two patients with Tangier disease (TD) and provide a narrative review of its clinical features, genetics, diagnosis, and management. A literature search of PubMed and Google Scholar was performed to identify English-language publications on TD, and relevant …

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Persistent Elevation of Thyroid-Stimulating Hormone Despite Levothyroxine Therapy Revealing Autoimmune Adrenal Insufficiency in an Adolescent With Autoimmune Thyroiditis: A Case Report and Review of Literature.

Janvi Biju, Sabitha Sasidharan Pillai

INTRODUCTION: Autoimmune thyroiditis (AIT) or Hashimoto thyroiditis is the most common cause of acquired hypothyroidism in the developed nations and these patients are at increased risk for other autoimmune conditions including autoimmune adrenal insufficiency (AAI). Routine screening for AAI is not recommended …

Supplemental Material for: Persistent Elevation of Thyroid-Stimulating Hormone Despite Levothyroxine Therapy Revealing Autoimmune Adrenal Insufficiency in an Adolescent With Autoimmune Thyroiditis: A Case Report and Review of Literature

figshare admin karger, Janvi Biju, Sabitha Sasidharan Pillai

Introduction: Autoimmune thyroiditis (AIT) or Hashimoto thyroiditis is the most common cause of acquired hypothyroidism in the developed nations and these patients are at increased risk for other autoimmune conditions including autoimmune adrenal insufficiency (AAI). Routine screening for AAI is not recommended …

ch (code pays fourni par la source)

Supplemental Material for: Persistent Elevation of Thyroid-Stimulating Hormone Despite Levothyroxine Therapy Revealing Autoimmune Adrenal Insufficiency in an Adolescent With Autoimmune Thyroiditis: A Case Report and Review of Literature

figshare admin karger, Janvi Biju, Sabitha Sasidharan Pillai

Introduction: Autoimmune thyroiditis (AIT) or Hashimoto thyroiditis is the most common cause of acquired hypothyroidism in the developed nations and these patients are at increased risk for other autoimmune conditions including autoimmune adrenal insufficiency (AAI). Routine screening for AAI is not recommended …

ch (code pays fourni par la source)

Autosomal dominant hypophosphatemic rickets caused by a novel pathogenic variant in FGF23

Babu Francis, Vidhu Ashok, Aysha Ashraf, Sabitha Sasidharan Pillai

Abstract We report a child with autosomal dominant hypophosphatemic rickets (ADHR) due to a novel pathogenic variant in fibroblast growth factor 23 (FGF23). A 1 year 10 month old girl was referred for rickets that did not respond to a single mega …

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Evolving trends in pediatric thyroid nodules and cancer management

Sabitha Sasidharan Pillai, Juliana Austin, Trevor E. Angell

Differentiated thyroid cancer (DTC) is the most common form of pediatric thyroid cancer, yet its management has been largely based on evidence from adults. Recent advances in science and clinical studies of pediatric DTC, particularly in papillary thyroid carcinoma, the predominant subtype, …

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Artificial intelligence in pediatric endocrinology: clinical applications, governance, and future directions

Sabitha Sasidharan Pillai, Ambika P. Ashraf

PURPOSE OF REVIEW: Artificial intelligence has transitioned from theoretical promise to practical implementation across medicine including pediatric endocrinology. This review examines artificial intelligence applications across diabetes care, obesity management, thyroid disorders, growth and puberty, and bone age assessment followed by discussion of …

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Central Hypothyroidism Associated with Oxcarbazepine in Pediatric Patients: Case Series and Literature Review.

Sabitha Sasidharan Pillai, Renée Robilliard, Meghan E. Fredette, Jose Bernardo Quintos et autres

Central hypothyroidism, a hypothyroid state resulting from insufficient stimulation by thyrotropin (TSH) of an otherwise normal thyroid gland, is a rare under-recognized side effect of oxcarbazepine. We describe four young patients diagnosed with central hypothyroidism likely due to oxcarbazepine and conducted a …

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Gut Microbiota and Metabolic Health: From Dysbiosis to Therapeutics

Sabitha Sasidharan Pillai, Ambika P. Ashraf

The gut microbiota (GM) is a pivotal regulator of host metabolism and a contributor to the pathophysiology of obesity, type 2 diabetes (T2D), and metabolic syndrome (MS). Disruptions in GM composition and function are collectively termed dysbiosis. This review synthesizes current evidence …

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Precision Medicine in Diabetes Phenotypes

Sabitha Sasidharan Pillai, Kamalika Mozumdar, Ambika P. Ashraf

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Determinants of Pubertal Growth Spurt in Constitutional Delay of Growth and Puberty in Boys Treated With Testosterone.

Ugen Lhamu, Lisa Swartz Topor, Carolina S. Cerezo, Mónica Serrano‐González et autres

BACKGROUND: Constitutional delay of growth and puberty (CDGP) is the most common cause of short stature and delayed puberty in children. Little is known about the changes in sex steroid and insulin like growth factor-1 (IGF-1) concentrations, body mass index (BMI), and …

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Vitamin D Intoxication in an Adolescent due to Over-Supplementation: A Case Report and Review of Literature

Laurel Gordon, Rachel Zipursky, Clement C. Cheung, Sabitha Sasidharan Pillai

Background/Objective: We describe a 17-year-old male who presented with symptomatic hypercalcemia due to prolonged, excessive ingestion of vitamin D through homemade milkshakes supplemented with vitamin D3. Case Presentation: The patient presented with abdominal pain, knee pain, and anorexia in the setting of …

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