Xiuzhong Zhang

Relationship between peripheral nerve invasion and lymph node metastasis and prognostic outcomes in gastric cancer patients

Sancheng Qiu, DONG Jie, Xiuzhong Zhang

Objective To investigate the relationship between perineural invasion (PNI) and lymph node metastasis (LNM) in patients with gastric cancer, and to evaluate the prognostic significance of PNI in patients undergoing radical gastrectomy.Methods Retrospective analysis was conducted on 225 patients with stage Ⅰ-Ⅲ …

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CBX8 suppresses autophagy-dependent senescence in colorectal cancer by modulating the mTOR signaling pathway

Tiankang Li, Enjian Zhang, Xin Liu, Hui Zhou et autres

models. Mechanistically, CBX8 inhibits autophagy-dependent senescence in CRC by modulating the mTOR signaling pathway through transcriptional repression of DDIT4, a known negative regulator of mTOR. CBX8 achieves this by recruiting TRIM28 to bind the promoter region of DDIT4, thereby maintaining the H3K27me3 …

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Lunar Orbital VLBI Experiment: Motivation, scientific purposes and status

Xiaoyu Hong, Weiren Wu, Qinghui Liu, Deng-Yun Yu et autres

Abstract The Lunar Orbital VLBI Experiment (LOVEX) is a scientific component of the Chinese Lunar Exploration Project (CLEP) Chang’E-7. The spaceborne component of LOVEX is implemented onboard the relay satellite QueQiao-2, which was launched on 20 March 2024, and later placed into …

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Lunar Orbital VLBI Experiment: motivation, scientific purposes and status

Xiaoyu Hong, Weiren Wu, Qinghui Liu, Deng-Yun Yu et autres

The Lunar Orbital VLBI Experiment (LOVEX) is a scientific component of the Chinese Lunar Exploration Project (CLEP) Chang'E-7. The spaceborne component of LOVEX is implemented onboard the relay satellite QueQiao-2, which was launched on 2024 March 20, and later placed into an …

Calmodulin-like 5 promotes PEDV replication by regulating late-endosome synthesis and innate immune response

Wen-Jun Tian, Xiuzhong Zhang, Jing Wang, Jianfeng Liu et autres

The infection caused by porcine epidemic diarrhea virus (PEDV) is associated with high mortality in piglets worldwide. Host factors involved in the efficient replication of PEDV, however, remain largely unknown. Our recent proteomic study in the virus-host interaction network revealed a significant …

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hsa_circ_0007919 promotes pancreatic cancer metastasis by modulating Sp1‐mediated THBS1 transcription

Xiao Ma, Lei Xu, Shuai Gong, Nai Wu et autres

CircRNAs are abnormally expressed in various cancers and play an important role in the occurrence and development of cancers. However, their biological functions and the underlying molecular mechanisms in pancreatic cancer (PC) metastasis are incompletely understood. Differentially expressed circRNAs were identified by …

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CA19‑9 is a significant prognostic factor in stage III gastric cancer patients undergoing radical gastrectomy

Xiao Ma, Xiaohua Zhou, Jiaxuan Guo, Xinyu Feng et autres

BACKGROUND: Due to the great heterogeneity of gastric cancer (GC), the prognosis of patients within a stage is very different. Therefore, it is necessary to identify the high risk factors for postoperative recurrence and metastasis and take appropriate therapeutic strategies to improve …

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Correction: hsa_circ_0007919 induces LIG1 transcription by binding to FOXA1/TET1 to enhance the DNA damage response and promote gemcitabine resistance in pancreatic ductal adenocarcinoma

Lei Xu, Xiao Ma, Xiuzhong Zhang, Chong Zhang et autres

found that the grouping tags in Fig. 1A was mislabeled and led to completely opposite representations, so they would like to correct the picture.

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Clinicopathological and prognostic significance of elevated BTF3 expression in gastric cancer

Pu Zhang, Chaochen Wang, Haiqing Wang, Xiuzhong Zhang

The purpose of this paper was to explore the significance of basic transcription factor 3 (BTF3) in the process and clinicopathological parameters of gastric cancer (GC) patients. GC tissues were collected in our hospital to detect the mRNA expression of BTF3 by …

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hsa_circ_0007919 induces LIG1 transcription by binding to FOXA1/TET1 to enhance the DNA damage response and promote gemcitabine resistance in pancreatic ductal adenocarcinoma

Lei Xu, Xiao Ma, Xiuzhong Zhang, Chong Zhang et autres

BACKGROUND: Circular RNAs (circRNAs) play important roles in the occurrence and development of cancer and chemoresistance. DNA damage repair contributes to the proliferation of cancer cells and resistance to chemotherapy-induced apoptosis. However, the role of circRNAs in the regulation of DNA damage …

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Bilateral decompressive craniotomy complicated by postoperative mycoplasma hominis epidural empyema and meningitis: A case report

Lizhen Chen, Yue Lu, Jia Liu, Xiuzhong Zhang et autres

RATIONALE: Postoperative intracranial mycoplasma hominis infection was a rare complication. Timely diagnosis was difficult due to its growth characteristics and nonspecific clinical symptoms. PATIENT CONCERNS: A 52-year-old man underwent bilateral decompressive craniotomy for severe traumatic brain injury. On the seventeenth day after …

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Plasma exosome-derived circGAPVD1 as a potential diagnostic marker for colorectal cancer

Tiankang Li, Tingting Zhou, Jin Wu, Heng Lv et autres

BACKGROUND: Although circular RNAs (circRNAs) have recently garnered interest as disease markers, they have been relatively poorly studied as a biomarker in colorectal cancer (CRC). In this study, we aimed to screen the exosome-derived circRNAs in CRC and explore their potential as …

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