Zhenyuan Wei

PI-VLA: Adaptive Symmetry-Aware Decision-Making for Long-Horizon Vision–Language–Action Manipulation

Yina Jian, Di Tian, Xuan-Jing Chen, Zhenyuan Wei et autres

Vision–language–action (VLA) models often suffer from limited robustness in long-horizon manipulation tasks—where robots must execute extended sequences of actions over multiple time steps to achieve complex goals—due to their inability to explicitly exploit structural symmetries and to react adaptively when such symmetries …

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Adaptive Multi-Stage Patent Claim Generation with Unified Quality Assessment

Chen-Wei Liang, Bin Guo, Zhenyuan Wei, Mujiangshan Wang

Current patent claim generation systems face three fundamental limitations: poor cross-jurisdictional generalization, inadequate semantic relationship modeling between claims and prior art, and unreliable quality assessment. We introduce a novel three-stage framework that addresses these challenges through relationship-aware similarity analysis, domain-adaptive claim generation, …

Adaptive Multi-Stage Patent Claim Generation with Unified Quality Assessment

Chen-Wei Liang, Bin Guo, Zhenyuan Wei, Mujiangshan Wang

Current patent claim generation systems face three fundamental limitations: poor cross-jurisdictional generalization, inadequate semantic relationship modeling between claims and prior art, and unreliable quality assessment. We introduce a novel three-stage framework that addresses these challenges through relationship-aware similarity analysis, domain-adaptive claim generation, …

PI-VLA: A Symmetry-Aware Predictive and Interactive Vision--Language--Action Framework for Robust Robotic Manipulation

Yina Jian, Tian Di, Zhenyuan Wei, Chen-Wei Liang et autres

Vision–language–action (VLA) models often suffer from limited robustness in long-horizon manipulation tasks due to their inability to explicitly exploit structural symmetries and to react adaptively when such symmetries are violated by environmental uncertainty. To address this limitation, this paper proposes PI-VLA, a …

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Biomimetic Multilayered Gas‐Foaming Scaffold with Sustained bFGF Delivery for Annulus Fibrosus Regeneration

Yujie Chen, Yucai Li, Zhenyuan Wei, Lin Du et autres

Current clinical treatments for intervertebral disc (IVD) herniation (e.g., discectomy) often lead to re-herniation, and tissue engineering scaffolds for annulus fibrosus (AF) regeneration remain scarce, particularly those capable of mimicking the multilayered structure of native AF. This study combines electrospinning with gas-foaming …

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Corrigendum to “Mechanically tough, adhesive, self-healing hydrogel promotes annulus fibrosus repair via autologous cell recruitment and microenvironment regulation” [Acta Biomaterialia, 2024, 178, 50-67]

Zhenyuan Wei, Han Ye, Yucai Li, Xiaoxiao Li et autres

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β‐Diketone Functionalized Microspheres Chelate Reactive Iron via Metal Coordination for Cartilage Repair

Yong Xu, Xin Gu, Xingchen Li, Yi-Cheng Chen et autres

Excessive intracellular iron accumulation can induce mitochondrial dysfunction, leading to chondrocyte ferroptosis, a key contributor to cartilage damage in osteoarthritis (OA). Here, micelle-microfluidic hydrogel microspheres, featuring keto-enol-thiol bridged nano-sized secondary structures that disintegrate within the intracellular peroxidative environment to reveal β-diketone groups …

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Programmable DNA‐Peptide Conjugated Hydrogel via Click Chemistry for Sequential Modulation of Peripheral Nerve Regeneration

Zhenyuan Wei, Xiaoxiao Li, Yi-Cheng Chen, Zhaopu Han et autres

Abstract During peripheral nerve regeneration, current deoxyribonucleic acid (DNA)‐based therapeutic platforms face the challenge of precisely regulating Schwann cells (SCs) fate to sustain their repair phenotype due to their inability to stably and precisely integrate multiple bioactive components. Herein, the strain‐promoted azide–alkyne …

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Three-dimensional gas-foamed scaffolds decorated with metal phenolic networks for cartilage regeneration

Yujie Chen, Wei Xu, Zhen Pan, Bohui Li et autres

Inflammation is a major impediment to the healing of cartilage injuries, yet bioactive scaffolds suitable for cartilage repair in inflammatory environments are extremely rare. Herein, we utilized electrospinning to fabricate a two-dimensional nanofiber scaffold (2DS), which was then subjected to gas foaming …

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Biomimetic nanofibrillar/hyaluronic acid hydrogels remodel the neuromodulatory microenvironment for enhanced bone regeneration

Jielin Wang, Han Ye, Bozhuang Zhou, Zhen Pan et autres

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Mechanically tough, adhesive, self-healing hydrogel promotes annulus fibrosus repair via autologous cell recruitment and microenvironment regulation

Zhenyuan Wei, Han Ye, Yucai Li, Xiaoxiao Li et autres

Annulus fibrosus (AF) defect is an important cause of disc re-herniation after discectomy. The self-regeneration ability of the AF is limited, and AF repair is always hindered by the inflammatory microenvironment after injury. Hydrogels represent one of the most promising materials for …

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Highly adhesive self-reinforce hydrogel for the amelioration of intervertebral disc degeneration: Eliminating reactive oxygen species and regulating extracellular matrix

Zhenyuan Wei, Bin Chai, Zhen Pan, Shun-zhe Zhang et autres

Intervertebral disc degeneration (IVDD) plays a pivotal etiological role in low back pain, which is a global cause of disability. Although the underlying pathological processes and mechanisms of IVDD are complex, oxidative stress and extracellular matrix degradation are recognized as crucial determinants …

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