Accès ouvert
2022
article
OpenAlex
Patricia Gerdes, Sue Mei Lim, Adam D. Ewing, Michael R. Larcombe et autres
Induced pluripotent stem cells (iPSCs) can in principle differentiate into any cell of the body, and have revolutionized biomedical research and regenerative medicine. Unlike their human counterparts, mouse iPSCs (miPSCs) are reported to silence transposable elements and prevent transposable element-mediated mutagenesis. Here …
au, es, us
(code pays fourni par la source)
Accès ouvert
2022
preprint
OpenAlex
Patricia Gerdes, Sue Mei Lim, Adam D. Ewing, Michael R. Larcombe et autres
Abstract Induced pluripotent stem cells (iPSCs) can in principle differentiate into any cell of the body, and have revolutionized biomedical research and regenerative medicine. Unlike their human counterparts, mouse iPSCs (miPSCs) are reported to silence transposable elements (TEs) and prevent TE-mediated mutagenesis. …
au, us, es
(code pays fourni par la source)
Accès ouvert
2018
article
OpenAlex
Thu H.M. Nguyen, Patricia E. Carreira, Francisco J. Sánchez‐Luque, Stephanie N. Schauer et autres
LINE-1 (L1) retrotransposons are a source of insertional mutagenesis in tumor cells. However, the clinical significance of L1 mobilization during tumorigenesis remains unclear. Here, we applied retrotransposon capture sequencing (RC-seq) to multiple single-cell clones isolated from five ovarian cancer cell lines and …
au, es
(code pays fourni par la source)
2016
article
OpenAlex
Cini James, Irina Buckle, Franziska Muscate, Masayuki Otsuka et autres
Enhancement of regulatory T cell (Treg cell) frequency and function is the goal of many therapeutic strategies aimed at treating type 1 diabetes (T1D). The interleukin-2 (IL-2) pathway, which has been strongly implicated in T1D susceptibility in both humans and mice, is …
au
(code pays fourni par la source)