Maria Gazouli

DAMPs and PAMPs in the Perioperative Period: Danger Signaling, Immune Dysfunction, and Oncologic Implications

Hector Katifelis, Theofania Lappa, Sofia Poulopoulou, Maria Gazouli

Background and Objectives: The perioperative period is characterized by marked biological stress responses that extend beyond direct tissue injury. Innate immune activation during surgery is largely driven by molecular danger signals. Surgical trauma, ischemia–reperfusion injury, blood transfusions, mechanical ventilation, and perioperative infections …

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How does genetic susceptibility impact the effectiveness of AF ablation?

Panagiotis Mililis, Dimitra Paraskevopoulou, Athanasios Saplaouras, Ourania Kariki et autres

Atrial fibrillation (AF) is a prevalent cardiac arrhythmia treated increasingly with catheter ablation, yet recurrence rates remain high. Genetic factors contribute to both AF susceptibility and response to therapy. This review summarizes evidence on how common AF-associated variants, polygenic risk scores, and …

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A proposed protocol for personalised prediction of opioid response in oncology patients with chronic pain using machine learning methods combining genetic and clinical factors

Anastasia Zompola, George Theodoropoulos, Maria Gazouli, George Nikolaos Zografos

Opioids are a cornerstone treatment for chronic pain in oncology patients, yet individual response varies widely due to genetic differences in CYP2D6 enzyme activity, which governs the metabolism of codeine and tramadol. Patients are classified into four metaboliser phenotypes, each associated with …

A quality-by-design engineering strategy for hybrid lipid–random copolymer nanoparticles optimization: methotrexate loading and effectiveness studies

Efstathia Triantafyllopoulou, Ilias Papantzimas, Anastasia Balafouti, Paraskevi Papakyriakopoulou et autres

The quality by design approach supports the rational development of pharmaceutical formulations. This strategy is particularly valuable in the case of hybrid nanoparticles, where complex molecular interactions pose challenges to predictability, control, and therapeutic performance. In this study, based on preliminary findings, …

A quality-by-design engineering strategy for hybrid lipid–random copolymer nanoparticles optimization: methotrexate loading and effectiveness studies

Efstathia Triantafyllopoulou, Ilias Papantzimas, Anastasia Balafouti, Paraskevi Papakyriakopoulou et autres

The quality by design approach supports the rational development of pharmaceutical formulations. This strategy is particularly valuable in the case of hybrid nanoparticles, where complex molecular interactions pose challenges to predictability, control, and therapeutic performance. In this study, based on preliminary findings, …

ExposoGenomics: integrating genome and exposome as jointly dynamic systems for causal discovery and precision health

Vasilis Vasiliou, Nicholas Katsanis, Giuseppe Novelli, Juergen K. V. Reichardt et autres

The past decade has witnessed an unprecedented convergence of exposomic technologies, population-scale genomics, and AI-enabled data science, creating the conditions for a new integrative discipline. Here we introduce ExposoGenomics, defined as the integrative study of how the genome and exposome, treated as …

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A quality-by-design engineering strategy for hybrid lipid–random copolymer nanoparticles optimization: methotrexate loading and effectiveness studies

Efstathia Triantafyllopoulou, Ilias Papantzimas, Anastasia Balafouti, Paraskevi Papakyriakopoulou et autres

The quality by design approach supports the rational development of pharmaceutical formulations. This strategy is particularly valuable in the case of hybrid nanoparticles, where complex molecular interactions pose challenges to predictability, control, and therapeutic performance. In this study, based on preliminary findings, …

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Evaluation of Longitudinal CD40 and CD40L Changes During Adjuvant Breast Cancer Therapy and Their Association with Left Ventricular Dysfunction

Georgia Efthymiou, Maria Anastasiou, Evangelos K. Oikonomou, Panagiotis Theofilis et autres

Background: Left ventricular (LV) dysfunction is a clinically important complication of anthracycline- and trastuzumab-based treatment in breast cancer. Inflammatory pathways may contribute to cancer therapy-related cardiac dysfunction, and the CD40/CD40 ligand (CD40L) axis has been implicated in vascular inflammation and myocardial injury. …

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3D-Bioprinted Multifunctional Nanocomposite Scaffolds for Alveolar Bone–Periodontal Ligament–Root Cementum Regeneration: A Narrative Review

Angeliki Tsantiri, Nikolaos I. Mourkiotis, Hector Katifelis, Xanthippi E. Dereka et autres

Periodontal disease remains one of the leading causes of tooth loss worldwide, highlighting the need for effective regeneration of alveolar bone, periodontal ligament, and cementum. The structural complexity and unique biological behavior of these tissues have historically posed significant challenges for clinical …

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Methods improving endoscopic retrograde cholangiopancreatography brush cytology in malignant biliary strictures

Kleoniki Kordeni, Antonios Vezakis, Theodoros Voulgaris, Athina Sotirianakou et autres

Accurate diagnosis of biliary strictures is crucial as malignant causes are associated with high morbidity and mortality, and unnecessary surgery for benign disease carries substantial risk. Endoscopic retrograde cholangiopancreatography with brush cytology remains the most widely used tissue sampling technique, but its …

Exploring the origins of esophagogastric junction cancer through omics: A focus on the Siewert II subclassification

Stamatina Vogli, Stavros P. Papadakos, Georgios D. Lianos, Paraskevas Gkolfakis et autres

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Predictors of Response to Induction Therapy with Ustekinumab in Patients with Ulcerative Colitis: Results from a National Study in Greece

Konstantina Chalakatevaki, Georgios Kokkotis, Maria Gazouli, Stratigoula Sakellariou et autres

Background/Objectives: Ustekinumab has been approved for the treatment of moderate to severe ulcerative colitis. Real-world data regarding its efficacy and the discovery of predictive factors of response need to be studied further. We aimed to evaluate the efficacy and identify predictors of …

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