Efstathia Triantafyllopoulou

A quality-by-design engineering strategy for hybrid lipid–random copolymer nanoparticles optimization: methotrexate loading and effectiveness studies

Efstathia Triantafyllopoulou, Ilias Papantzimas, Anastasia Balafouti, Paraskevi Papakyriakopoulou et autres

The quality by design approach supports the rational development of pharmaceutical formulations. This strategy is particularly valuable in the case of hybrid nanoparticles, where complex molecular interactions pose challenges to predictability, control, and therapeutic performance. In this study, based on preliminary findings, …

A quality-by-design engineering strategy for hybrid lipid–random copolymer nanoparticles optimization: methotrexate loading and effectiveness studies

Efstathia Triantafyllopoulou, Ilias Papantzimas, Anastasia Balafouti, Paraskevi Papakyriakopoulou et autres

The quality by design approach supports the rational development of pharmaceutical formulations. This strategy is particularly valuable in the case of hybrid nanoparticles, where complex molecular interactions pose challenges to predictability, control, and therapeutic performance. In this study, based on preliminary findings, …

A quality-by-design engineering strategy for hybrid lipid–random copolymer nanoparticles optimization: methotrexate loading and effectiveness studies

Efstathia Triantafyllopoulou, Ilias Papantzimas, Anastasia Balafouti, Paraskevi Papakyriakopoulou et autres

The quality by design approach supports the rational development of pharmaceutical formulations. This strategy is particularly valuable in the case of hybrid nanoparticles, where complex molecular interactions pose challenges to predictability, control, and therapeutic performance. In this study, based on preliminary findings, …

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Lipid/copolymer hybrid drug delivery systems: From design to performance

Efstathia Triantafyllopoulou, Dimitriοs Selianitis, Maria Chountoulesi, Maria Karayianni et autres

In recent years, nanomedicine has become very popular in the pharmaceutical field as it raises opportunities for precise and more effective pharmacotherapy. Among others, hybrid lipid/polymer systems have gained a lot of interest as drug delivery nanoplatforms having several assets: combine the …

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From cellular debris to intelligent therapeutics: recent advances and emerging paradigms in extracellular vesicle-based nanomedicine, highlighting technological improvements and clinical prospects

Efstathia Triantafyllopoulou, Zoi Kardasi, Νatassa Pippa, Maria G. Roubelakis et autres

Abstract Extracellular vesicles (EVs) participate in numerous fundamental biological processes, making them highly promising candidates for applications in nanomedicine, regenerative medicine, and diagnostics. Owing to their intrinsic biocompatibility, molecular complexity, and selective targeting capabilities, EVs have already been investigated extensively in both …

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Design and development of niacinamide lipid and polymeric nanoparticles and in vitro permeation studies using human epidermis

Dimitra Bompou, Emanuela Di Biase, Alexandra Sarika, Efstathia Triantafyllopoulou et autres

Design and development of niacinamide nanoparticles using Design of Experiments.

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Physicochemical Morphological Evaluation and Stability Assessment of Nanoemulsions Containing Nutrients for Parenteral Nutrition

Πάνος Παπανδρέου, Efstathia Triantafyllopoulou, Ioannis Pispas, Sophia Havaki et autres

Parenteral nutrition is an integral part of the nutritional support of critically ill neonates, infants, and children in the intensive care units (ICUs) and at home. Therefore, the adequacy and the effectiveness of parenteral nutrition, PN, support are among the major concerns …

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Lipid-Based Drug Delivery Systems: Concepts and Recent Advances in Transdermal Applications

Lefkothea Antonara, Efstathia Triantafyllopoulou, Maria Chountoulesi, Νatassa Pippa et autres

Lipid-based nanocarriers are ideal drug delivery systems for transdermal administration due to their biocompatibility and biodegradability. Their lipophilicity and/or similarity to the natural lipids of the epidermis enable intermolecular interactions with the lipid membrane and therefore result in effective passage through the …

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Recent advances in niosome-based transdermal drug delivery systems

Lefkothea Antonara, Efstathia Triantafyllopoulou, Maria Chountoulesi, Νatassa Pippa et autres

Niosomes are promising drug delivery nanosystems for transdermal administration. They exhibit several advantages for drug delivery and targeting applications, i.e., biocompatibility, increased physical stability, modified drug release properties, low cost, and easy scale-up. Additionally, they are deemed as favorable candidates due to …

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pH-Responsive Hydrogels: Recent Advances in Pharmaceutical Applications

Efstathia Triantafyllopoulou, Paraskevi-Evelina Goula, Vasiliki Karali, Maria Chountoulesi et autres

Hydrogels are three-dimensional polymeric systems, being able to accommodate different categories of bioactive agents and act as promising drug delivery systems in many different biomedical applications. Due to their extended 3D network, hydrogels exhibit many advantages, such as extensive loading capacity and …

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Designing Polysaccharide Graft Copolymers for Drug Delivery Applications

Aristeidis Papagiannopoulos, Theodore Sentoukas, Efstathia Triantafyllopoulou, Stergios Pispas et autres

One of the key advantages of polysaccharide graft copolymers is their biocompatibility. Graft polymerization enhances polysaccharides by preserving their beneficial properties while introducing new functionalities. Advances in controlled radical polymerization and ring-opening polymerization (ROP) techniques have opened new synthetic pathways for creating …

P.9.7 NOVEL HYBRID DSPC:P(OEGMA-CO-LMA) NANOPLATFORMS: EXPLORING THE DESIGN PARAMETERS AFFECTING THEIR PERFORMANCE

Efstathia Triantafyllopoulou, Dimitris Selianitis, A. Balafouti, N. Lagopati et autres