Lijiang Gu

A Phenome-Wide Association and Mendelian Randomization Study of Genetically Predicted Membranous Nephropathy with Multiple Diseases

Alida Wenghaerbai, Akehu Alemasi, Lijiang Gu, Jianjun Deng et autres

INTRODUCTION: Membranous nephropathy constitutes a significant proportion of cases leading to end-stage renal disease. In such instances, the accurate distinction between primary and secondary forms is crucial for proper treatment. Consequently, we systematically examined the link between genetically predicted membranous nephropathy and …

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Hexylaminolevulinic acid in precision medicine: A review of advances in drug delivery and combination therapeutics

Lijiang Gu, Pan Zhang, Yibo Mei, Zheng Wang et autres

• Hexylaminolevulinic acid (HAL) causes the accumulation of protoporphyrin IX (PpIX) in tumor cells within a hormonal microenvironment by upregulating coproporphyrinogen oxidase (CPOX) and protoporphyrinogen oxidase (PPOX) and inhibiting ferrochelatase (FECH). • HAL's superior lipophilicity and cellular uptake over ALA, leads to …

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A novel 450 nm blue laser-mediated sinoporphyrin sodium-based photodynamic therapy inactivates Cutibacterium acnes through stress-mediated metabolic alterations

Hengtong Fan, Zejun Ren, Shuqi Chen, Tingting Huang et autres

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A Novel Photosensitizer Based 450-nm Blue Laser-Mediated Photodynamic Therapy Induces Apoptosis in Colorectal Cancer – in Vitro and in Vivo Study

Yibo Mei, Lijiang Gu, Yuhang Chen, Pan Zhang et autres

Background: Due to its non-invasive and widely applicable features, photodynamic therapy (PDT) has been a prominent treatment approach against cancer in recent years. However, its widespread application in clinical practice is limited by the dark toxicity of photosensitizers and insufficient penetration of …

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Gut microbiota in the association between obesity and kidney function decline: a metagenomics-based study in a rat model

Akehu Alemasi, Lijiang Gu, Yilun Zhou

Objectives: Obesity can induce dysbiosis in the gut microbiota and is considered a separate risk factor for kidney function decline.Nonetheless, the precise function of intestinal microorganisms in facilitating the connection between obesity and kidney function decline remains uncertain.Hence, the objective of this …

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Gut Microbiota Disorders in Obesity-Associated Benign Prostatic Hyperplasia in Rats

Lijiang Gu, Akehu Alemasi, Yuhang Chen, Xing Li et autres

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Genetic association between membranous nephropathy and malignancies: a two-sample Mendelian randomisation study

Akehu Alemasi, Lijiang Gu, Yilun Zhou

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A novel PDT: 5-aminolevulinic acid combined 450 nm blue laser photodynamic therapy significantly promotes cell death of HR-HPV infected cells

Yuqing Chen, Yibo Mei, Lijiang Gu, Xing Li et autres

Human papillomavirus (HPV) infection and related diseases are clinical challenges. The efficacy of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) using red laser (630 ± 5 nm) is remarkable and safe. In this study, we aim to investigate the efficacy of ALA-450 nm PDT …

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Additional file 1 of A novel 450-nm laser-mediated sinoporphyrin sodium-based photodynamic therapy induces autophagic cell death in gastric cancer through regulation of the ROS/PI3K/Akt/mTOR signaling pathway

Xing Li, Lijiang Gu, Yuhang Chen, Xiaobing Wang et autres

Additional file 1: Fig. S1. Cellular uptake of DVDMS and cytotoxic effects of PDT in GC cells. (A and B) Representative fluorescence images and quantitative analysis of the intracellular uptake of DVDMS after different incubation time points. Scale bar = 10 μm. …

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A novel 450-nm laser-mediated sinoporphyrin sodium-based photodynamic therapy induces autophagic cell death in gastric cancer through regulation of the ROS/PI3K/Akt/mTOR signaling pathway

Xing Li, Lijiang Gu, Yuhang Chen, Xiaobing Wang et autres

BACKGROUND: Photodynamic therapy (PDT) has become an ideal and promising therapeutic method for fighting cancer, but its common application in clinical practice is prevented by the limitations of expensive devices in light sources and phototoxicity in photosensitizers. The aim of this study …

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Photoactivatable metal organic framework for synergistic ferroptosis and photodynamic therapy using 450 nm laser

Yuhang Chen, Lijiang Gu, Bohan Ma, Xing Li et autres

Photodynamic therapy (PDT) is an appealing treatment modality by producing reactive oxygen species (ROS) with photosensitizers (PSs) to induce cell apoptosis, but still suffering poor efficacy in treating hypoxic solid tumor. Herein, we have developed a nanocarrier (naming HAFeR) by encapsulating PSs …

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Integrated Analysis and Identification of Critical RNA-Binding Proteins in Bladder Cancer

Lijiang Gu, Yuhang Chen, Xing Li, Yibo Mei et autres

RBPs in the development and progression of BC remains unclear. Here, we elucidated the role of RBPs in predicting the survival of patients with BC. Clinical information and RNA sequencing data of the training and validation cohorts were downloaded from the Cancer …

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