Shuntaro Ikeda

Pcgf5 controls the exit from totipotency in mouse embryonic stem cells

Satoshi Mashiko, Shinnosuke Honda, Shuntaro Ikeda, Tomoyuki Tsukiyama

) during ZGA in 2-cell embryos, controls exit from the 2C-like state in mouse ESCs. Using a reporter ESC line carrying MERVL-tdTomato and Zscan4c-EGFP (MtZG), we manipulated Pcgf5 dosage bidirectionally. Doxycycline (Dox)-inducible overexpression (OE) of Pcgf5 reduced the double-positive (DP) 2C-like population. …

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A Case of Confirmed Diagnosis of Wild-Type Transthyretin Cardiac Amyloidosis from a Bladder Cancer Resection Specimen

Koki Fujio, Akinori Higaki, Noriyoshi Miura, KEISHO KUROKAWA et autres

Long-read sequencing reveals transposable element-derived chimeric transcripts at zygotic genome activation in mammalian embryos

Saki Kawakami, K. Kitao, Shuntaro Ikeda, Shinnosuke Honda

Abstract Background Transposable elements (TEs) are mobile genomic sequences that constitute one-third to one-half of the mammalian genome. Recently, TEs have been recognized for their important roles as cis-regulatory elements. TEs are broadly activated during zygotic genome activation (ZGA) in mammalian embryos, …

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5-Fluorouracil–associated coronary vasospasm with takotsubo-like myocardial dysfunction: A case report

KEISHO KUROKAWA, Toru Miyoshi, Yasuhisa Nakao, Shigehiro Miyazaki et autres

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Myocardial Infarction Following Systemic Air Embolism During Computed Tomography-Guided Lung Biopsy

Amane Otoi, Toru Miyoshi, Haruhiko Higashi, Shunsuke Tamaki et autres

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Prognostic value of pretest probability of heart failure with preserved ejection fraction in patients with coronary artery disease: an insight from the CLIDAS-PCI database

Tomoaki Nishikawa, Shunsuke Tamaki, Kazuhisa Nishimura, Yasutaka Ihara et autres

Coronary artery disease (CAD) is a major risk factor for the development of heart failure (HF) with preserved ejection fraction (HFpEF) and is associated with increased mortality. However, an optimal strategy to screen for HFpEF among patients with CAD has not yet …

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Correlation between estimated plasma volume status and extracellular volume ratio determined by bioelectrical impedance analysis in cardiovascular disease patients

Ryo Miyabe, Akinori Higaki, Keisho Kurokawa, Tomoaki Nishikawa et autres

< 0.01), suggesting that BIA-derived indices may more accurately reflect cardiac congestion than formula-based plasma volume estimates.

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Screening for heart failure with preserved ejection fraction using the BREATH2 score: diagnostic performance and prognostic value

Masaki Kinoshita, Tatsuro Tasaka, Kaori Fujimoto, Sumiko Sato et autres

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Cost-Effectiveness of TAVI vs Minimally Invasive SAVR for Low-Risk Aortic Stenosis in Japan

Hiroshi Kawakami, Taisuke Nakayama, Ryo Miyabe, Yasuhisa Nakao et autres

BACKGROUND: Transcatheter aortic valve implantation (TAVI) and minimally invasive surgical aortic valve replacement (MICS-AVR) are both less invasive options for treating severe aortic stenosis (AS). However, most cost-effectiveness analyses have compared TAVI with conventional full-sternotomy surgery, and the economic value of TAVI …

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Procedural Complexity and Outcomes of Catheter Ablation for Atrial Fibrillation in Patients With Sick Sinus Syndrome

Rikako Horie, Hiroshi Kawakami, KEISHO KUROKAWA, Tomoki Fujisawa et autres

BACKGROUND: The procedural complexity and outcomes of atrial fibrillation (AF) ablation in patients with sick sinus syndrome (SSS) remain unclear. This study aimed to evaluate procedural strategies, including pulmonary vein isolation (PVI) and additional ablation, and AF recurrence according to SSS status. …

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Exercise capacity and quality-of-life improvements after catheter ablation in patients with clinically asymptomatic persistent atrial fibrillation

Tomoki Fujisawa, Hiroshi Kawakami, KEISHO KUROKAWA, Rikako Horie et autres

Background The clinical importance of catheter ablation in asymptomatic persistent atrial fibrillation (PeAF) remains uncertain, as current indications mainly focus on symptom relief. Asymptomatic patients may have unrecognized impairments in exercise capacity or quality of life (QoL), but prospective data are limited. …

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Complementary cardiac functional assessment using systolic time intervals and bioelectrical impedance analysis

T Nishikawa, Akinori Higaki, Keisho Kurokawa, Arisa Abe et autres

Background The Forrester classification remains a cornerstone for assessing haemodynamic status in heart failure, yet its clinical application is restricted by the invasiveness of right heart catheterisation. This study aimed to develop a novel, non-invasive and reproducible alternative by integrating bioelectrical impedance …

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