Haruhiko Higashi

A Case of Confirmed Diagnosis of Wild-Type Transthyretin Cardiac Amyloidosis from a Bladder Cancer Resection Specimen

Koki Fujio, Akinori Higaki, Noriyoshi Miura, KEISHO KUROKAWA et autres

5-Fluorouracil–associated coronary vasospasm with takotsubo-like myocardial dysfunction: A case report

KEISHO KUROKAWA, Toru Miyoshi, Yasuhisa Nakao, Shigehiro Miyazaki et autres

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Myocardial Infarction Following Systemic Air Embolism During Computed Tomography-Guided Lung Biopsy

Amane Otoi, Toru Miyoshi, Haruhiko Higashi, Shunsuke Tamaki et autres

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Correlation between estimated plasma volume status and extracellular volume ratio determined by bioelectrical impedance analysis in cardiovascular disease patients

Ryo Miyabe, Akinori Higaki, KEISHO KUROKAWA, Tomoaki Nishikawa et autres

< 0.01), suggesting that BIA-derived indices may more accurately reflect cardiac congestion than formula-based plasma volume estimates.

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Exercise capacity and quality-of-life improvements after catheter ablation in patients with clinically asymptomatic persistent atrial fibrillation

Tomoki Fujisawa, Hiroshi Kawakami, KEISHO KUROKAWA, Rikako Horie et autres

Background The clinical importance of catheter ablation in asymptomatic persistent atrial fibrillation (PeAF) remains uncertain, as current indications mainly focus on symptom relief. Asymptomatic patients may have unrecognized impairments in exercise capacity or quality of life (QoL), but prospective data are limited. …

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Coexistence of Wild-Type Transthyretin Cardiac Amyloidosis and Monoclonal Gammopathy in a Patient With Polycythemia Vera

Amane Otoi, Akinori Higaki, Masaki Maruta, Haruhiko Higashi et autres

Polycythemia vera is a type of myeloproliferative neoplasm characterized by panmyelosis, with a predominant increase in erythrocyte mass. In contrast, monoclonal gammopathy of undetermined significance is classified as a premalignant plasma cell disorder and is characterized by elevated levels of monoclonal γ-globulin …

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Complementary cardiac functional assessment using systolic time intervals and bioelectrical impedance analysis

Tomoaki Nishikawa, Akinori Higaki, KEISHO KUROKAWA, Arisa Abe et autres

Background The Forrester classification remains a cornerstone for assessing haemodynamic status in heart failure, yet its clinical application is restricted by the invasiveness of right heart catheterisation. This study aimed to develop a novel, non-invasive and reproducible alternative by integrating bioelectrical impedance …

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Association Between Human Papillomavirus Infection Status and Coronary Artery Calcification in Patients With Oropharyngeal Cancer

Tomoaki Nishikawa, Akinori Higaki, SOHEI MITANI, Haruhiko Higashi et autres

BACKGROUND/AIM: Human papillomavirus (HPV) is a known risk factor for oropharyngeal cancer (OPC); however, its role in atherosclerosis remains controversial. This study aimed to investigate the association between HPV type 16 infection status and coronary artery calcification (CAC) in patients with OPC. …

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An Implantable Right Ventricular Assist Device for End-Stage Right Heart Failure: First Report From Japan

Toru Miyoshi, Takashi Nishimura, Haruhiko Higashi, Hironori Izutani et autres

Severe right heart failure is typically managed using external right ventricular assist devices (RVADs) or inotropic agents while awaiting heart transplantation. Here, we report a successful case using an implantable RVAD to treat end-stage right-sided heart failure caused by arrhythmogenic right ventricular …

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Ventricular Tachycardia and Takotsubo-like Syndrome in a Patient Undergoing Afatinib Treatment for Advanced Lung Adenocarcinoma

KEISHO KUROKAWA, Akinori Higaki, Yasuhisa Nakao, Tomoaki Nishikawa et autres

Afatinib is a second-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor approved for the treatment of non-small-cell lung cancer. We herein report a 61-year-old woman who developed dyspnea and ventricular tachycardia (VT) after afatinib treatment for lung adenocarcinoma. Following restoration of …

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Validation of N-Terminal Pro B-Type Natriuretic Peptide Threshold for Early Detection of Pre-Heart Failure in a General Japanese Population ― Toon Health Study ―

Shigehiro Miyazaki, Shinji Inaba, Haruhiko Higashi, Shunsuke Tamaki et autres

BACKGROUND: An N-terminal pro B-type natriuretic peptide (NT-proBNP) level above 125 pg/mL has been suggested as a universal marker for heart failure (HF). Furthermore, the Japanese Heart Failure Society (JHFS) advises follow-up when NT-proBNP exceeds 55 pg/mL, even if it remains below …

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Bilateral Venous Access for Cardiac Resynchronization Therapy in a Hemodialysis Patient With Cabozantinib-associated Heart Failure

Amane Otoi, Akinori Higaki, Noriyoshi Miura, KEISHO KUROKAWA et autres

Background: Cabozantinib, a multi-targeted tyrosine kinase inhibitor, is widely used for the treatment of renal and hepatic cancers. While cabozantinib-associated cardiotoxicity is rare, it has been documented in several cases. In most instances, cancer therapeutics-related cardiac dysfunction (CTRCD) is managed by discontinuing …

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