Accès ouvert
2026
article
OpenAlex
Elizabeth Loxterkamp, Audrey Luo, Francesco Sanvito, Collin T. Le et autres
BACKGROUND: Pretreatment apparent diffusion coefficient (ADC) histogram analysis-specifically the lower Gaussian peak mean (ADC-L)-is a predictive biomarker of progression-free survival (PFS) and overall survival (OS) in recurrent IDH-wildtype glioblastoma receiving anti-VEGF treatment including bevacizumab. IDH-mutant gliomas differ biologically from glioblastoma, as they …
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(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Xinchen Chen, Sarah L. Perry, Bei Wang, Elizabeth Loxterkamp et autres
Tissue-specific gene knockout by CRISPR/Cas9 is a powerful approach for characterizing gene functions during development. However, this approach has not been successfully applied to most Drosophila tissues, including the Drosophila neuromuscular junction (NMJ). To expand tissue-specific CRISPR to this powerful model system, …
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(code pays fourni par la source)
Accès ouvert
2023
preprint
OpenAlex
Xinchen Chen, Sarah L. Perry, Bei Wang, Shuran Wang et autres
ABSTRACT Tissue-specific gene knockout by CRISPR/Cas9 is a powerful approach for characterizing gene functions in animal development. However, this approach has been successfully applied in only a small number of Drosophila tissues. The Drosophila motor nervous system is an excellent model system …
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(code pays fourni par la source)
Accès ouvert
2021
article
OpenAlex
Elizabeth Loxterkamp, Jaaram Cha, Katharine Wu, Janessa Sullivan et autres
, we expanded upon existing literature and compared spontaneous movement, sensitivity to mechanosensation, and sensitivity to chemosensation between males and hermaphrodites. In our paradigms, we found that males and hermaphrodites exhibit similar spontaneous movement as well as similar slow and sustained behaviors …
us
(code pays fourni par la source)