Selim Guersel

Microglial Activation and Tau Accumulation in the Alzheimer's Disease Spectrum: Insights from Longitudinal PET Imaging

Marco Öchsner, Matthias Brendel, Nicolai Franzmeier, Lena‐Katharina Trappmann et autres

Abstract Background Recent evidence suggests that microglial activation mirrors tau accumulation along highly connected brain regions, but their relation remains unclear. We examined (a) longitudinal changes in microglial activation in Alzheimer's disease spectrum (ADS) compared to healthy controls (HC) (b) whether these …

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Microglial Activation and Tau Accumulation in the Alzheimer's Disease Spectrum: Insights from Longitudinal PET Imaging

Marco Öchsner, Matthias Brendel, Nicolai Franzmeier, Lena-Katharina Trappmann et autres

Background Recent evidence suggests that microglial activation mirrors tau accumulation along highly connected brain regions, but their relation remains unclear. We examined (a) longitudinal changes in microglial activation in Alzheimer's disease spectrum (ADS) compared to healthy controls (HC) (b) whether these changes …

Early Locus Coeruleus noradrenergic axon loss drives olfactory dysfunction in Alzheimer’s disease

Carolin Meyer, Theresa Niedermeier, Paul Feyen, Felix L. Struebing et autres

Abstract Alzheimer’s disease (AD) often begins with non-cognitive symptoms such as olfactory deficits, which can predict later cognitive decline, though the mechanisms remain unclear. Pathologically, the brainstem locus coeruleus (LC), the main source of the neurotransmitter noradrenalin (NA) modulating olfactory information processing …

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Perivascular space and white matter hyperintensities in Alzheimer’s disease: associations with disease progression and cognitive function

Philine Schirge, Robert Perneczky, Toshiaki Taoka, Adriana L. Ruiz‐Rizzo et autres

BACKGROUND: Alzheimer's disease (AD) is the leading cause of dementia, characterized by the accumulation of amyloid-beta (Aβ) and neurofibrillary tangles. Recent studies emphasize the role of vascular factors, including the glymphatic system, in AD pathogenesis, particularly in Aβ clearance. The diffusion tensor …

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Investigating Reactive Astrocytosis in Alzheimer's Disease Using [18F]Fluorodeprenyl‐D2 PET Imaging

Boris‐Stephan Rauchmann, Selim Guersel, Carolin Kurz, Simon Lindner et autres

Abstract Background Alzheimer's Disease (AD) is often accompanied by neuroinflammation, which manifests prior to significant cognitive decline. Reactive astrocytosis is a hallmark of such inflammation, potentially serving as an early biomarker for AD pathology. Our study employs [18F]fluorodeprenyl‐D2 ([18F]F‐DED) positron emission tomography …

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Noradrenergic axon loss drives olfactory dysfunction in Alzheimer’s disease

Carolin Meyer, Theresa Niedermeier, Paul Feyen, Felix Strübing et autres

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Plasma amyloid beta X‐42/X‐40 ratio and cognitive decline in suspected early and preclinical Alzheimer's disease

Jonathan S. Vogelgsang, Niels Hansen, Melina Stark, Michael Wagner et autres

INTRODUCTION: Blood-based biomarkers are a cost-effective and minimally invasive method for diagnosing the early and preclinical stages of amyloid positivity (AP). Our study aims to investigate our novel immunoprecipitation-immunoassay (IP-IA) as a test for predicting cognitive decline. METHODS: We measured levels of …

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Associations between sex, body mass index and the individual microglial response in Alzheimer’s disease

Gloria Biechele, Boris‐Stephan Rauchmann, Daniel Janowitz, Katharina Büerger et autres

Abstract Background and objectives 18-kDa translocator protein position-emission-tomography (TSPO-PET) imaging emerged for in vivo assessment of neuroinflammation in Alzheimer’s disease (AD) research. Sex and obesity effects on TSPO-PET binding have been reported for cognitively normal humans (CN), but such effects have not …

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Value of blood‐based biomarkers for differential diagnosis of Alzheimer’s disease: the ActiGliA cohort

Carolin Kurz, Laura De Carli, Selim Guersel, Isabelle Schrurs et autres

Abstract Background Cerebrospinal fluid (CSF) and positron emission tomography (PET) biomarkers of Alzheimer’s disease (AD), ß‐amyloid (Aß) and tau, can identify early disease stages with high accuracy. However, this approach is not suitable for routine clinical care because of the high costs …

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Blood‐brain barrier disruption measured by dynamic contrast‐enhanced MRI in Alzheimer’s disease

Boris‐Stephan Rauchmann, Hannah Toth, Selim Guersel, Philine Schirge et autres

Abstract Background Alzheimer’s disease (AD) is characterized by the accumulation of amyloid beta (Aβ) plaques in the brain. Blood‐brain barrier (BBB) dysfunction has been associated with AD. Aβ‐plaques have been found to disrupt the BBB, leading to increased permeability and invasion of …

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Blood‐brain barrier disruption measured by dynamic contrast‐enhanced MRI in Alzheimer’s disease

Boris‐Stephan Rauchmann, Hannah Toth, Selim Guersel, Philine Schirge et autres

Abstract Background Alzheimer’s disease (AD) is characterized by the accumulation of amyloid beta (Aß) plaques in the brain. Blood‐brain barrier (BBB) dysfunction has been associated with AD. Aß‐plaques have been found to disrupt the BBB, leading to increased permeability and invasion of …

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Associations between sex, body mass index and the individual microglial response in Alzheimer’s disease

Gloria Biechele, Boris‐Stephan Rauchmann, Daniel Janowitz, Katharina Büerger et autres

Abstract Background and Objectives: 18-kDa translocator protein position-emission-tomography (TSPO-PET) imaging emerged for in vivo assessment of neuroinflammation in Alzheimer’s disease (AD) research. Sex and obesity effects on TSPO-PET binding have been reported for cognitively normal humans (CN), but such effects have not …

de, ch (code pays fourni par la source)