Michael Kuepper

6th International Symposium on Molecular Allergology (ISMA)

Christiane Hilger, Kyra Swiontek, Jörg Fischer, François Hentges et autres

Background: Delayed food anaphylaxis upon consumption of red meat is attributed to specific IgE-antibodies directed to galactose-α-1,3-galactose (α-Gal).Anaphylactic reactions may occur after ingestion of meat from different mammals, mainly beef and pork, but reactions to lamb, rabbit or horse have also been …

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Blockade of thymic stromal lymphopoietin (TSLP) receptor inhibits TSLP-driven proliferation and signalling in lymphoblasts from a subset of B-precursor ALL patients

Tina Vetter, Andreas Borowski, Andreas Wohlmann, Michael Kuepper et autres

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Soluble extracellular matrix metalloproteinase inducer ( EMMPRIN , EMN ) regulates cancer‐related cellular functions by homotypic interactions with surface CD 147

Nadine Knutti, Michael Kuepper, Karlheinz Friedrich

EMMPRIN (extracellular matrix metalloproteinase inducer) is a widely expressed glycoprotein and a member of the immunoglobulin superfamily which exists in both a membrane-spanning and a soluble form. Homotypic interactions of EMMPRIN underlie its multiple roles in normal development and pathological situations such …

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Impact of smoking on dendritic cell phenotypes in the airway lumen of patients with COPD

Paul Stoll, Kai Bratke, Andrea Bier, Katharina Garbe et autres

BACKGROUND: Myeloid dendritic cells (DCs) are increased in the airway wall of patients with chronic obstructive pulmonary disease (COPD), and postulated to play a crucial role in COPD. However, DC phenotypes in COPD are poorly understood. METHODS: Function-associated surface molecules on bronchoalveolar …

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Vitamin D binding protein and vitamin D in human allergen-induced endobronchial inflammation

Kai Bratke, Anna Wendt, Katharina Garbe, Michael Kuepper et autres

Allergic asthma is a chronic disease of the airways associated with airway hyperresponsiveness, a variable degree of airflow obstruction, airway remodelling and a characteristic airway inflammation. Factors of the vitamin D axis, which include vitamin D metabolites and vitamin D binding protein …

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Fluticasone impact on airway dendritic cells in smokers: a randomized controlled trial

Marek Lommatzsch, Ulrike Kraeft, Laura Troebs, Katharina Garbe et autres

BACKGROUND: Myeloid Dendritic cells are key drivers of inflammation in smoke-related lung diseases, whereas plasmacytoid DCs play a crucial role in the defense against infections. Effects of inhaled corticosteroids (ICS) on airway DCs in smokers are unknown. METHODS: In this randomized, double-blind, …

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Expression analysis and specific blockade of the receptor for human thymic stromal lymphopoietin (TSLP) by novel antibodies to the human TSLPRα receptor chain

Andreas Borowski, Tina Vetter, Michael Kuepper, Andreas Wohlmann et autres

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Plasmacytoid dendritic cells in allergic asthma and the role of inhaled corticosteroid treatment

Kai Bratke, C. Prieschenk, Katharina Garbe, Michael Kuepper et autres

BACKGROUND: Plasmacytoid dendritic cells (pDCs) infiltrate sites of acute Th2-dominant inflammation, but their role in allergic asthma remains unclear. OBJECTIVE: To characterize circulating pDCs from patients with allergic asthma outside their respective allergen season. METHODS: Adhesion molecules, co-stimulatory molecules, immunoglobulin receptors and …

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Nabucco Gas Pipeline Project - A Challenging Project in the Prequalification Phase

Michael Kuepper, Joachim Roloff

Abstract The Nabucco Gas Pipeline is a transit and transport pipeline that will serve as a connection of several gas reserves in the Caspian Region as well as the Middle East to Europe. The Nabucco Gas Pipeline is one of the longest …

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Geselleschaftsnachrichten Information de la Societe

Katrin Hostettler, Ueli Studler, Michael Tamm, Martin Hugo Brutsche et autres

Front & Back Matter

Katrin Hostettler, Ueli Studler, Michael Tamm, Martin Hugo Brutsche et autres

Altered phenotype of blood dendritic cells in patients with acute pneumonia

Katharina Dreschler, Kai Bratke, Sebastian Petermann, Petra Thamm et autres

Background: Dendritic cells (DCs) play a key role in the host defense against inhaled pathogens. However, the phenotype of blood DCs in patients with acute respiratory infections is unknown. Objective: To investigate the number and the expression of function-associated molecules of blood …

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