John A. Hamilton

Potential Significance of CCL17 in Psoriatic Arthritis

Kevin Ming‐Chin Lee, Adrian Achuthan, Matthew Jiang, John A. Hamilton et autres

The data that support the findings of this study are available from the corresponding author upon reasonable request.

au (code pays fourni par la source)

Screening of the FDA-approved drug library identifies CCL17 inhibitors that block arthritic pain

Mahtab Eivazitork, Tanya Lupancu, Keith Lim, Yukuan Huang et autres

Rheumatoid arthritis (RA) is an inflammatory and destructive autoimmune polyarthritis that causes pain, swelling and deformity in the joints. While clinical trials targeting GM-CSF in RA are showing promise, the potential side effects of anti-GM-CSF therapy highlight the need for identifying downstream …

au (code pays fourni par la source)

Therapeutic blockade of CCL17 in obesity-exacerbated osteoarthritic pain and disease

Ming-Chin Lee, Tanya Lupancu, Stacey N. Keenan, Adrian Achuthan et autres

OBJECTIVES: We previously reported that CCL17 gene-deficient mice are protected from developing pain-like behaviour and exhibit less disease in destabilization of medial meniscus (DMM)-induced OA, as well as in high-fat diet (HFD)-exacerbated DMM-induced OA. Here, we explored if therapeutic neutralization of CCL17, …

au (code pays fourni par la source)

Colony Stimulating Factors (CSFs)

Adrian Achuthan, Andrew J. Fleetwood, John A. Hamilton

au (code pays fourni par la source)

The Anatomic Pathology Hospitalist Model : A Novel Approach to Frozen Section Practice in a Tertiary Care Center

Ellen E. Chapel, David B. Chapel, L. Priya Kunju, John A. Hamilton et autres

CONTEXT.—: Challenges to staffing a high-quality frozen section service include consolidation of health systems and pathology practices, off-campus relocation of some pathology offices, growing numbers of stand-alone surgery centers, and subspecialization among pathologists and surgeons. To address these challenges, we developed a …

us (code pays fourni par la source)

The mode of action of IL-23 in experimental inflammatory arthritic pain and disease

Ming-Chin Lee, Tanya Lupancu, Leon Chang, Carl L. Manthey et autres

OBJECTIVES: We have previously reported using gene-deficient mice that the interleukin (IL)-23p19 subunit is required for the development of innate immune-driven arthritic pain and disease. We aimed to explore here, using a number of in vivo approaches, how the IL-23p19 subunit can …

au, us (code pays fourni par la source)

IL-23p19 in osteoarthritic pain and disease

Ming-Chin Lee, Tanya Lupancu, Adrian Achuthan, Richard de Steiger et autres

OBJECTIVE: We have previously reported that the interleukin-23 p19 subunit (IL-23p19) is required for experimental inflammatory arthritic pain-like behavior and disease. Even though inflammation is often a characteristic feature of osteoarthritis (OA), IL-23 is not usually considered as a therapeutic target in …

au (code pays fourni par la source)

IL-23 regulation of myeloid cell biology during inflammation

Ming-Chin Lee, Tanya Lupancu, Leon Chang, Carl L. Manthey et autres

Interleukin (IL)-23 is implicated in the pathogenesis of several inflammatory diseases and is usually linked with helper T cell (Th17) biology. However, there is some data linking IL-23 with innate immune biology in such diseases. We therefore examined the effects of IL-23p19 …

au, us (code pays fourni par la source)

Signaling pathways underlying TGF-β mediated suppression of IL-12A gene expression in monocytes

Tetiana Hourani, Mahtab Eivazitork, Thivya Balendran, Ming-Chin Lee et autres

Transforming growth factor-β (TGF-β) is a pleiotropic cytokine essential for multiple biological processes, including the regulation of inflammatory and immune responses. One of the important functions of TGF-β is the suppression of the proinflammatory cytokine interleukin-12 (IL-12), which is crucial for mounting …

au (code pays fourni par la source)

TRPV4 is expressed by enteric glia and muscularis macrophages of the colon but does not play a prominent role in colonic motility

Pradeep Rajasekhar, Simona Carbone, Stuart T. Johnston, Cameron J. Nowell et autres

Abstract Background Mechanosensation is an important trigger of physiological processes in the gastrointestinal tract. Aberrant responses to mechanical input are associated with digestive disorders, including visceral hypersensitivity. Transient Receptor Potential Vanilloid 4 (TRPV4) is a mechanosensory ion channel with proposed roles in …

au, gb, ca, us (code pays fourni par la source)

Epigenetic and transcriptional regulation of CCL17 production by glucocorticoids in arthritis

Tanya Lupancu, Ming-Chin Lee, Mahtab Eivazitork, Cecil Hor et autres

resulted in decreased CCL17 production. This delineated pathway potentially provides new therapeutic options for the treatment of many inflammatory conditions, where GCs are used as an anti-inflammatory drug but without the associated adverse side effects.

au (code pays fourni par la source)

Targeting transcription factors for therapeutic benefit in rheumatoid arthritis

Thivya Balendran, Keith Lim, John A. Hamilton, Adrian Achuthan

Rheumatoid arthritis (RA) is a destructive inflammatory autoimmune disease that causes pain and disability. Many of the currently available drugs for treating RA patients are aimed at halting the progression of the disease and alleviating inflammation. Further, some of these treatment options …

au (code pays fourni par la source)