Rakesh Jalali

Advanced Radiotherapy Across a Multi‐Geography Referral Network for Children With Ewing Sarcoma and Rhabdomyosarcoma: Treatment Delivery and Early Outcomes—A Single‐Centre Experience

Srinivas Chilukuri, Abhilasha Sinha, Sham Sundar, Vishnu Ramanujan et autres

BACKGROUND: Children with Ewing sarcoma (ES) and rhabdomyosarcoma (RMS) across Asia, the Middle East and Africa often require cross-border referral for advanced radiotherapy, risking a disruption of multimodality care. We evaluated whether a structured referral network could deliver advanced radiotherapy while preserving …

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Compliance, toxicity and quality of life in a Phase 3 randomized trial of adjuvant temozolomide versus PCV in grade 2–3 gliomas

Nandini Menon, Tejpal Gupta, Abhishek Chatterjee, Amit Choudhari et autres

ABSTRACT Background: Procarbazine, lomustine, vincristine (PCV) and temozolomide (TMZ) are adjuvant therapy options for grade 2 and 3 gliomas. We report compliance, toxicity, and quality of life (QoL) outcomes from an ongoing study comparing these regimens. Objectives: The primary objective was to …

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TEMPORAL LOBE CHANGES FOLLOWING IMPT FOR SKULLBASE TUMOURS: CLINICAL AND DOSIMETRIC CORRELATION.

Sapna Nangia, Patrick Joshua, Nagarjuna Burela, Gaganpreet Singh et autres

Results: The proposed Particle Therapy Center comprised two PBT and one BNCT treatment rooms.Patient demand forecasting estimated annual utilization of approximately 600-800 patients for PBT and 250 patients for BNCT to sufficiently support phased implementation and stable service uptake.Estimated capital investment costs …

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COMPARISON OF EXTREME VERSUS MODERATE HYPOFRACTIONATION FROM A PROSPECTIVE STUDY OF IMAGE-GUIDED INTENSITY-MODULATED PROTON BEAM THERAPY FOR PROSTATE CANCER

Srinivas Chilukuri, Sham Sundar, Manikandan Arjunan, Abhilasha Sinha et autres

Conclusions: SFPT is effective and good tolerance in clinical practice for bulky tumors patients, and SFPT can help these weekly patients relieve symptoms and control tumors quickly.

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AOSNP‐ADAPTR resource level‐based recommendations on practical diagnostic strategies for medulloblastomas and other embryonal tumors

Chitra Sarkar, Maysa Al‐Hussaini, Vani Santosh, Vaishali Suri et autres

WHO CNS5 mandates integrated histo-molecular classification of medulloblastomas (MBs) and other CNS embryonal tumors. However, advanced molecular diagnostics remain inaccessible in many low- and lower-middle-income countries (LICs/LMICs), limiting implementation of molecularly informed risk stratification and therapy. The ADAPTR group (Adapting Diagnostic Approaches …

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PROTON THERAPY FOR RECTAL CANCERS: FIRST INDIAN EXPERIENCE -A GUIDE FOR POSSIBLE CASE SELECTION AND PROMISING INCREMENTAL BENEFITS

Ashu Abhishek, Ashwathy Mathew, Manikandan Arjunan, Venkatesh Munikrishnan et autres

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Effectiveness of Intensity Modulate Proton Therapy in Managing Complex Multiple Meningiomas: A Dosimetric and Radiobiological Comparative Study with Helical Tomotherapy on Neurological Risk

Gaganpreet Singh, Dayananda Sharma, S Gayen, Krishnan Ganapathy et autres

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Improving total bone marrow and lymphoid irradiation: feasibility of intensity-modulated proton therapy (IMPT) and dosimetric comparison with helical tomotherapy (HT)

Dayananda Sharma, Arjunan Manikandan, Gaganpreet Singh, Sanjib Gayen et autres

BACKGROUND AND PURPOSE: This study aims to develop and validate a novel whole-body intensity-modulated proton therapy (IMPT) approach for total marrow/lymphatic irradiation (TMI/TMLI) and compare its efficacy to helical tomotherapy (HT). MATERIALS AND METHODS: Whole-body IMPT plans were designed using five isocenters …

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1563 Ten-year tumour control, functional preservation with high-precision conformal RT in paediatric craniopharyngiomas – subset results of a Phase-3 RCT

Rakesh Jalali, Jayant S. Goda, Suman Ghosh, Abhishek Chatterjee et autres

Establishing the content validity of patient-reported outcome measures used in neuro-oncology based on the WHO ICF framework: Part of the RANO-PRO initiative

Ogechukwu A Asogwa, Linda Dirven, Tobias Walbert, Terri S. Armstrong et autres

BACKGROUND: Instruments to assess patient-reported outcomes (PRO) should generate high-quality evidence. Reliable PRO evidence is essential to policymakers, in conjunction with outcomes such as survival and radiological response, to understand the net clinical benefit of antitumor treatments. This study aimed to establish …

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High-precision radiotherapy achieves excellent long-term control and preserves function in pediatric craniopharyngioma—Subset analysis of a randomized trial

Rakesh Jalali, Abhishek Chatterjee, Savita Goswami, Nalini S. Shah et autres

BACKGROUND: The evolving treatment paradigm in children and adolescents with craniopharyngioma (CP) aims at minimizing late functional sequelae. Advanced radiotherapeutic techniques offer theoretical advantages of preserving neurological functions; however, clinical evidence of such is limited. The current study constitutes a secondary analysis …

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Proton and Heavy Ion Therapy

Siddhartha Laskar, Jifmi Jose Manjali, Srinivas Chilukuri, Dayanand Sharma et autres