Mayrel Labrada

Itolizumab regulates activating and inhibitory signals on effector cells, improving their cytotoxicity against CD318+ tumor cell lines

C. Muñoz, Rydell Alvarez Arzola, A. Perez, Milagro de la Caridad Frometa Campanón et autres

Introduction The CD6‐CD318 axis has emerged as a potential target for immuno‐oncology. Recent work has shown that blocking the CD6‐CD318 interaction with a murine anti‐human CD6 antibody increases lymphocyte cytotoxicity. However, several studies have demonstrated the drawbacks associated with the clinical use …

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PREVAX: A Phase I Clinical Trial of an EGF-Based Vaccine in Moderate-to-Severe COPD Patients

Jenysbel de la C. Hernandez Reyes, Orestes Santos Morales, Laura Hernández Moreno, Pedro Pablo Pino Alfonso et autres

BACKGROUND: EGFR has been suggested to contribute to COPD development and progression. Excessive ligand activation of the receptor leads to epithelial hyperproliferation and increased production of mucus, together with alterations in the primary cilia. The present study was designed to evaluate the …

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Sticholysin II shows similar immunostimulatory properties to LLO stimulating dendritic cells and MHC-I restricted T cell responses of heterologous antigen

Anaixis del Valle, Nelson Acosta‐Rivero, Rady J. Laborde, Yoelys Cruz‐Leal et autres

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Marine Seagrass Extract of Thalassia testudinum Suppresses Colorectal Tumor Growth, Motility and Angiogenesis by Autophagic Stress and Immunogenic Cell Death Pathways

Ivones Hernández, Idania Rodeiro, Ken Declerck, Claudina Angela Perez-Novo et autres

Marine plants have become an inexhaustible reservoir of new phytopharmaceuticals for cancer treatment. We demonstrate in vitro/in vivo antitumor efficacy of a standardized polyphenol extract from the marine angiosperm Thalassia testudinum (TTE) in colon tumor cell lines (RKO, SW480, and CT26) and …

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Racotumomab-alum vaccine as active immunotherapy for neuroectodermal pediatric tumors

Maurenis Hernández, M. C. González, Anaisa C. Amores, Juan C. Arranz et autres

Background: Primitive neuroectodermal tumors frequently express NeuGlycolylGM3 gangliosides (NeuGcGM3).Racotumomab-alum is a therapeutic vaccine able to induce specific antibody response against NeuGcGM3.The aim of this study was to evaluate safety and immunogenicity of this vaccine in pediatric patients.Methods: A phase I, single arm, …

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Efficacy of direct current generated by multiple-electrode arrays on F3II mammary carcinoma: experiment and mathematical modeling

Narciso Antonio Villar Goris, Jorge Luis García Rodríguez, Maraelys Morales González, Beatriz Olivares Borges et autres

BACKGROUND: The modified Gompertz equation has been proposed to fit experimental data for direct current treated tumors when multiple-straight needle electrodes are individually inserted into the base perpendicular to the tumor long axis. The aim of this work is to evaluate the …

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Antitumor effects of the GM3(Neu5Gc) ganglioside-specific humanized antibody 14F7hT against Cmah-transfected cancer cells

Denise Dorvignit, Kayluz Frias Boligan, Ernesto Relova-Hernández, Marilyn Clavell et autres

The GM3(Neu5Gc) ganglioside represents a tumor-specific antigen that is considered a promising target for cancer immunotherapy. We previously demonstrated that the humanized antibody 14F7hT, specific for this ganglioside, exhibited significant antitumor effects in preclinical hematological tumor models. As this antibody recognizes human …

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Dose‐response study for the highly aggressive and metastatic primary F3II mammary carcinoma under direct current

Maraelys Morales González, Dasha Fuentes Morales, Luis Enrique Bergues Cabrales, Daniel Jay Pérez et autres

Electrochemical treatment has been suggested as an effective alternative to local cancer therapy. Nevertheless, its effectiveness decreases when highly aggressive primary tumors are treated. The aim of this research was to understand the growth kinetics of the highly aggressive and metastatic primary …

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GM3(Neu5Gc) ganglioside: an evolution fixed neoantigen for cancer immunotherapy

Mayrel Labrada, Denise Dorvignit, Giselle Hevia, Nely Rodríguez‐Zhurbenko et autres

Numerous molecules have been considered as targets for cancer immunotherapy because of their levels of expression on tumor cells, their putative importance for tumor biology, and relative immunogenicity. In this review we focus on the ganglioside GM3(Neu5Gc), a glycosphingolipid present on the …

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Chemical Characterization and Cytotoxic Potential of a Chloroform Fraction Obtained from Marine Plant Thalassia testudinum

Riera Romo M, Marrero Delange D, Hernandez Balmaseda, Kethia González et autres

Marine plants and algae represent a prolific source of new bioactive metabolites with multiple pharmacological applications. The hydroethanolic extract of marine angiosperm Thalassia testudinum is enriched in polyphenols and glucopyranosides and it has demonstrated cytoprotective and antioxidant properties in different models, however, …

Cyclooxygenase Inhibition in Cancer Immunotherapy: Combination of Indomethacin with Cancer Vaccines Is Not Always Beneficial

Giselle Hevia, Isabel Pablos, Marilyn Clavell, Judith Raymond et autres

Cyclooxygenase (COX)-1, but preferable COX-2 catalyzes the synthesis of PGE2 in several tumors, promoting angiogenesis and a suppressive inflammation in their microenvironments. Different types of cancer vaccines have been combined with COX-2 inhibitors, assuming that its particular mechanism of action will not …

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Mecanismos inmunológicos asociados a la vacunación terapéutica de cáncer con NGcGM3/VSSP

Mayrel Labrada

Antecedentes: El cancer es un grave problema de salud por la incidencia y la mortalidad crecientes, asi como por el impacto psicologico y el hecho de que los pacientes no mueren generalmente por el tumor primario, sino por las metastasis. Estudios previos …