Gottfried Fischer

Repeat ABO-B-incompatible living-donor kidney transplantation

Ismail Daoudi, Andreas Heinzel, Gottfried Fischer, László Wagner et autres

To the Editor, We present a 34-year-old woman admitted in July 2023 for a repeat ABO-B-incompatible (donor: ABO-B, recipient: ABO-O) living-donor kidney transplantation (LDKT). Her first allograft (ABO-compatible) failed at 5 years because of medication non-adherence leading to (anti-HLA-A2 positive) antibody-mediated rejection …

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The serine/threonine kinase PIM3 acts as essential gatekeeper of T cell functions 2743

Tobias Frey, K. Schaffer, Marlene C. Gerner, Simone Allram et autres

Abstract Description Intracellular signaling factors are important targets for immunosuppressive drugs. We report a selective induction of the serine/threonine kinase Provirus Integration site for Moloney murine leukemia virus 3 (PIM3), but not its homologs PIM1 and PIM2, in activated human T cells. …

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Severe COVID-19 induces prolonged elevation of the acute-phase protein pentraxin 3

Bernhard Kratzer, Robert B. Stieger, Doris Trapin, Pia Gattinger et autres

Introduction: During the acute-phase of COVID-19, elevated levels of several acute-phase proteins, such as C-reactive protein (CRP), mannose-binding lectin (MBL), pentraxin 3 (PTX-3), serum amyloid A (SAA) and surfactant protein D (SP-D), are associated with severe to fatal clinical outcomes. Typically, these …

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CD38-targeted therapy with Daratumumab in clinical lung transplantation: A single-center experience

Giuseppe Maggioni, Aya Sophia, Daniela Koren, Zsófia Kovács et autres

Background: Antibody-mediated rejection remains a major threat to long-term graft function after lung transplantation. Current therapies aim to eliminate circulating antibodies and suppress B-cell-activity but often fail to reduce donor-specific antibodies. Daratumumab, a monoclonal antibody targeting CD38, has shown potential in depleting …

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Prediction of antibody-mediated rejection by quantifying eplets potentially targeted by preformed donor-specific antibodies

K. Doberer, Sebastian Kapps, D. Kriks, Gottfried Fischer et autres

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Enhanced and long-lasting SARS-CoV-2 immune memory in individuals with common cold coronavirus cross-reactive T cell immunity

David M. Florian, Michael Bauer, Amelie Popovitsch, Ingrid Faé et autres

With the continuous emergence of novel SARS-CoV-2 variants, long-lasting and broadly reactive cellular and humoral immunity is critical for durable protection from COVID-19. We investigated SARS-CoV-2-specific T cell immunity in relation to antibodies, infection outcome and disease severity and assessed its durability …

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Differential decline of SARS‐CoV‐2‐specific antibody levels, innate and adaptive immune cells, and shift of Th1/inflammatory to Th2 serum cytokine levels long after first COVID‐19

Bernhard Kratzer, Pia Gattinger, Doris Trapin, Paul Ettel et autres

Abstract Background SARS‐CoV‐2 has triggered a pandemic and contributes to long‐lasting morbidity. Several studies have investigated immediate cellular and humoral immune responses during acute infection. However, little is known about long‐term effects of COVID‐19 on the immune system. Methods We performed a …

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Polyomavirus Nephropathy in ABO Blood Group-Incompatible Kidney Transplantation: Torque Teno Virus and Immunosuppressive Burden as an Approximation to the Problem

Michael Eder, Tarek A. Schrag, Ella F. Havel, Alexander Kainz et autres

Introduction Earlier reports suggest that patients after ABO-incompatible kidney transplantation (ABOi) are at enhanced risk to develop BK-virus (BKV) nephropathy (BKPyVAN). It remains elusive whether this is a result of more intense immunosuppression or an ABOi-associated ‘intrinsic attribute'. To address this question, …

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CD38 Antibody Daratumumab as an Add-On Rescue Therapy for AMR - First Report in Clinical Lung Transplantation

C. Hillebrand, S. Auner, Daniela Koren, Gottfried Fischer et autres

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CD38-Antibody Daratumumab in Allosensitized Recipients for Heart Transplantation: Outcomes and 3-Years of Single-Centre Experience

C. Atteneder, R. Moayedifar, D. Koren, Gottfried Fischer et autres

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Feasibility Study of Bronchoalveolar Donor-Derived Cell Free DNA as Diagnostic Biomarker of Graft Health

Z. Kovacs, K. Hoetzenecker, Péter Jaksch, Panja M. Boehm et autres

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Resolving unknown nucleotides in the IPD-IMGT/HLA database by extended and full-length sequencing of HLA class I and II alleles

Christina E.M. Voorter, Mathijs Groeneweg, Timo I. Olieslagers, Ingrid Faé et autres

In the past, identification of HLA alleles was limited to sequencing the region of the gene coding for the peptide binding groove, resulting in a lack of sequence information in the HLA database, challenging HLA allele assignment software programs. We investigated full-length …

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