Mathijs Groeneweg

Full-length gene polymorphism of the non-classical HLA-E in Estonian individuals

Timo I. Olieslagers, Ingrid Tagen, Mathijs Groeneweg, Marcel G.J. Tilanus et autres

Estonia is a small country in the Baltic region of Northern Europe with 1.3 million inhabitants. As a coastal area, the population of Estonia was subjected to migration influences. Due to this admixture of populations, HLA gene diversity in Estonia is interesting …

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Characterisation of the ABO Blood Group Phenotypes Using Third-Generation Sequencing

Fredrick M. Mobegi, Samuel S. Bruce, Naser El‐Lagta, Felipe Ayora et autres

Third-generation sequencing (TGS), also known as long-read sequencing, has become a promising tool in clinical and research laboratories because it delivers high-resolution results with unmatched throughput. Specialised immunohematology laboratories currently employ sequencing-based methods to characterise rare ABO blood group phenotypes that cannot …

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Somatic Genomic Alterations in Haematological Tumours Can Interfere With Accurate HLA and Chimerism Diagnostics

Timo I. Olieslagers, Mathijs Groeneweg, Gwendolyn N. Y. van Gorkom, Erik A.M. Beckers et autres

Tumour cells, which are often found in the peripheral blood of patients with acute leukaemia, may harbour multiple somatic alterations throughout the genome, including changes in the HLA region and short tandem repeat (STR) regions. We investigated whether such somatic alterations interfere …

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The 18th International HLA & Immunogenetics workshop project report: Creating fully representative MHC reference haplotypes

Nicholas R. Pollock, Ticiana D.J. Farias, Katherine M. Kichula, Jürgen Sauter et autres

A fundamental endeavor of the International Histocompatibility and Immunogenetics Workshop (IHIW) was assembling a collection of DNA samples homozygous through the MHC genomic region. This collection proved invaluable for assay development in the histocompatibility and immunogenetics field, for generating the human reference …

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Resolving unknown nucleotides in the IPD-IMGT/HLA database by extended and full-length sequencing of HLA class I and II alleles

Christina E.M. Voorter, Mathijs Groeneweg, Timo I. Olieslagers, Ingrid Faé et autres

In the past, identification of HLA alleles was limited to sequencing the region of the gene coding for the peptide binding groove, resulting in a lack of sequence information in the HLA database, challenging HLA allele assignment software programs. We investigated full-length …

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Polymorphic differences within HLA‐C alleles contribute to alternatively spliced transcripts lacking exon 5

Femke A. I. Ehlers, Timo I. Olieslagers, Mathijs Groeneweg, Gerard M.J. Bos et autres

The HLA genes are amongst the most polymorphic in the human genome. Alternative splicing could add an extra layer of complexity, but has not been studied extensively. Here, we applied an RNA based approach to study the influence of allele polymorphism on …

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HLA Class I Molecules as Immune Checkpoints for NK Cell Alloreactivity and Anti-Viral Immunity in Kidney Transplantation

Burcu Duygu, Timo I. Olieslagers, Mathijs Groeneweg, Christina E.M. Voorter et autres

Natural killer (NK) cells are innate lymphocytes that can kill diseased- or virally-infected cells, mediate antibody dependent cytotoxicity and produce type I immune-associated cytokines upon activation. NK cells also contribute to the allo-immune response upon kidney transplantation either by promoting allograft rejection …

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Polymorphism clustering of the 21.5 kb DPA‐promoter‐DPB region reveals novel extended full‐length haplotypes

Linh Truong, Benedict M. Matern, Mathijs Groeneweg, Lloyd D’Orsogna et autres

DPB1 and DPA1 genes share the same promoter region. Single-nucleotide polymorphisms (SNPs) within the regulatory regions of DP have been reported. This study hypothesizes that by including the SNPs in the promoter region of DP, extended haplotypes are defined, and promoter polymorphism …

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Long-Read Nanopore Sequencing Validated for Human Leukocyte Antigen Class I Typing in Routine Diagnostics

Benedict M. Matern, Timo I. Olieslagers, Mathijs Groeneweg, Burcu Duygu et autres

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Insights into the polymorphism in HLA‐DRA and its evolutionary relationship with HLA haplotypes

Benedict M. Matern, Timo I. Olieslagers, Christina E.M. Voorter, Mathijs Groeneweg et autres

HLA-DRA encodes the alpha chain of the HLA-DR protein, one of the classical HLA class II molecules. Reported polymorphism within HLA-DRA is currently limited compared with other HLA genes, as only a single polymorphism encodes an amino acid difference in the translated …

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P060 HLA-DRA polymorphism defines multiple lineages of DRB1*13∼DRB3∼DQB1 haplotypes

Benedict M. Matern, Timo I. Olieslagers, Christina E.M. Voorter, Mathijs Groeneweg et autres

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P046 Characterization of novel single-nucleotide polymorphisms in the promoter of HLA-DP region

Linh Truong, Benedict M. Matern, Mathijs Groeneweg, Marcel G.J. Tilanus et autres

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