Tanja Schlaikjær Hartwig

From the shadow of pregnancy loss to a new pregnancy: couples’ perspectives and medical care priorities

Emily Koert, Rebecca Mackel, Tanja Schlaikjær Hartwig, Lone Schmidt et autres

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How big is the time window for cell-free fetal DNA testing after pregnancy loss and which factors are associated with a successful result?

Yasmin Isabella El Sammaa-Aru, Tanja Schlaikjær Hartwig, Maiken Hemme Bro‐Jørgensen, Emma Juuel Münter et autres

STUDY QUESTION: How fast does cell-free fetal DNA (cffDNA) decline after early pregnancy loss and which factors affect the decline? SUMMARY ANSWER: After pregnancy loss cffDNA declines gradually with detectable levels persisting up to 3 days post-tissue passage correlating with β-hCG decline. …

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Sequence Diversity Lost in Early Pregnancy

Gudny A. Arnadottir, Hákon Jónsson, Tanja Schlaikjær Hartwig, Jennifer R. Gruhn et autres

(Abstracted from Nature 2025;642(8068):672–681) Mutations in germ cells are passed from parent to child and occur before fertilization; variations can be evaluated using somatic tissue samples, and germline mutations that appear de novo in offspring (DNMs) have been studied extensively. Many DNMs …

First Do No Harm: Is Participation in Research Harmful to Couples Experiencing Pregnancy Loss? Experiences from the Copenhagen Pregnancy Loss Cohort

Clara Brinkmann, David Westergaard, Henriette Svarre Nielsen, Tanja Schlaikjær Hartwig

Aims and background: Pregnancy loss is a common life event with wide-reaching consequences, and further research is needed to better understand, treat, and care for this patient group.However, participation in research requires the couple to stay involved in the loss, and some …

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Systematic description of the development of a complex health intervention of information and support in a new pregnancy after pregnancy loss

Emily Koert, Sarah Fredsted Villadsen, Rebecca Mackel, Helene Cagara et autres

BACKGROUND: In this paper, we present a systematic description of the development method of a complex health intervention (PREGAFTERPL) for couples with prior pregnancy loss (PL) to provide information and support in a new pregnancy using co-production and prototyping. METHODS: A three-stage …

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O-077 Novel findings of thyroid dysfunction in pregnancy loss – suggestions for screening and further research

Sofie Bliddal, David Westergaard, Tanja Schlaikjær Hartwig, Laura Emilie Vexø et autres

Abstract Study question Do women experiencing pregnancy loss have undetected high thyroid stimulating hormone (TSH) levels? Is thyroid (dys)function associated with the risk of a euploid pregnancy loss? Summary answer Few women with pregnancy loss and high TSH were detected with current …

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P-473 Adenomyosis progression over time in patients with repeated pregnancy loss: ultrasound-based observations

Giuliana Beneduce, Nicolaj Brandt, Tanja Schlaikjær Hartwig, Laura Emilie Vexø et autres

Abstract Study question Does adenomyosis progress over time in women with two or more pregnancy losses? Summary answer Among women with two or more pregnancy losses, adenomyosis tends to gradually progress over time with notable changes observed in the junctional zone. What …

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O-218 Symptoms and signs of adenomyosis according to the revised MUSA criteria in 375 women with pregnancy loss and known ploidy of the pregnancy loss

Nicolaj Brandt, Giuliana Beneduce, Tanja Schlaikjær Hartwig, Laura Emilie Vexø et autres

Abstract Study question • Does adenomyosis increase risk of euploid pregnancy loss (PL)? • Is there a correlation of euploid PL and direct and/or indirect features of adenomyosis? Summary answer No increased risk of euploid PL was observed in women with ultrasonographic …

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O-156 Pregnancy loss has significant mental health consequences, a prospective cohort study of 2,085 women and 1,212 partners

Astrid Marie Kolte, Daniel Skipper, Tanja Schlaikjær Hartwig, Kilian Vomstein et autres

Abstract Study question What is the prevalence of stress, depression and anxiety among couples experiencing pregnancy loss and is this affected by reproductive history? Summary answer Depression, stress, and anxiety are common after pregnancy loss, especially among women. Couples with prior losses …

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Different thyroid hormone profiles in women with euploid compared to aneuploid pregnancy loss - a prospective cohort study

Sofie Bliddal, David Westergaard, Tanja Schlaikjær Hartwig, Laura Vexoe et autres

Immune changes in pregnancy: associations with pre-existing conditions and obstetrical complications at the 20th gestational week—a prospective cohort study

David Westergaard, Agnete Troen Lundgaard, Kilian Vomstein, Kathrine Vauvert Römmelmayer Hviid et autres

BACKGROUND: Pregnancy is a complex biological process and serious complications can arise when the delicate balance between the maternal and semi-allogeneic fetal immune systems is disrupted or challenged. Gestational diabetes mellitus (GDM), pre-eclampsia, preterm birth, and low birth weight pose serious threats …

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Vaginal Microbiota Transplantation (VMT) for treatment of vaginal dysbiosis without the use of antibiotics – A Double-Blinded Randomized Controlled Trial in healthy women with vaginal dysbiosis

Tine Wrønding, Kilian Vomstein, Kevin DeLong, Agnete Troen Lundgaard et autres

Abstract Here we describe the first double-blinded, randomized, placebo-controlled trial (RCT) on vaginal microbiota transplantation (VMT) without antibiotics in women with both symptomatic and asymptomatic vaginal dysbiosis. Forty-nine women were randomly assigned to VMT or placebo. The trial did not show a …

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