Pablo Carbonell

Living buildings with living electronics: towards biologically intelligent biohybrids

Pablo Carbonell, Rachel Armstrong, Jorge Barriuso, Ioannis Ieropoulos

es, be, gb (code pays fourni par la source)

Les raons de per què encara costa unir les peces de l'origen de la vida

J. Peretó, Pablo Carbonell

es (code pays fourni par la source)

RetroRules v1 (2019): SQLite Database providing retrosynthesis rules

Thomas Duigou, Melchior. Auteur de lettres Du Lac, Pablo Carbonell, Jean‐Loup Faulon

This deposit provides the SQLite database snapshot corresponding to the first public release of RetroRules (v1, 2019). RetroRules is a curated collection of reaction rules derived from biochemical reactions, generated at multiple rule diameters (promiscuity levels) and optionally encoding stereochemistry. In this …

fr, es, gb (code pays fourni par la source)

RetroRules v1 (2019): SQLite Database providing retrosynthesis rules

Thomas Duigou, Melchior. Auteur de lettres Du Lac, Pablo Carbonell, Jean‐Loup Faulon

This deposit provides the SQLite database snapshot corresponding to the first public release of RetroRules (v1, 2019). RetroRules is a curated collection of reaction rules derived from biochemical reactions, generated at multiple rule diameters (promiscuity levels) and optionally encoding stereochemistry. In this …

fr, es, gb (code pays fourni par la source)

BiosInt: Biosensor-based smart design of pathway dynamic regulation for industrial biomanufacturing

Hèctor Martín Lázaro, Irene Otero‐Muras, Pablo Carbonell

Abstract Industrial-scale production of bio-based chemicals in the circular green bioeconomy still faces inefficiencies arising from scaling up challenges. Biosensor mediated control of metabolic pathways has been proposed as a strategy to improve the performance of those bioprocesses. By linking industrial biosynthetic …

es (code pays fourni par la source)

Before LUCA: unearthing the chemical roots of metabolism

Pablo Carbonell, Juli Peretό

The transition from geochemistry to biochemistry marks a fundamental event in the emergence of life. Recent advancements in computational methods and systems chemistry offer new insights into how primitive biochemical systems evolved. While early Earth chemistry laid the foundation for protometabolic processes, …

es (code pays fourni par la source)

Challenges and Opportunities in Smart Biosensing for Biomanufacturing

Mara Pisani, Pablo Carbonell

Traditional metabolic engineering has largely focused on the direct construction of synthetic metabolic pathways, often overlooking the critical role of regulation. In contrast, natural metabolic pathways are inherently tightly regulated, enabling robust performance in dynamic environments. Dynamic regulation of synthetic metabolic pathways …

gb, it, es (code pays fourni par la source)

Context-Aware Biosensor Design Through Biology-Guided Machine Learning and Dynamical Modeling

Jonathan Tellechea‐Luzardo, Hèctor Martín Lázaro, C. Pérez, David Henriques et autres

Addressing the challenge of achieving a global circular bioeconomy requires efficient and robust bio-based processes operating at different scales. These processes should also be competitive replacements for the production of chemicals currently obtained from fossil resources, as well as for the production …

es (code pays fourni par la source)

Computer-aided design and implementation of efficient biosynthetic pathways to produce high added-value products derived from tyrosine in Escherichia coli

Sofia Ferreira, Alexandra Balola, Anastasia Sveshnikova, Vassily Hatzimanikatis et autres

Developing efficient bioprocesses requires selecting the best biosynthetic pathways, which can be challenging and time-consuming due to the vast amount of data available in databases and literature. The extension of the shikimate pathway for the biosynthesis of commercially attractive molecules often involves …

pt, ch, gb, es (code pays fourni par la source)

DetSpace: a web server for engineering detectable pathways for bio-based chemical production

Hèctor Martín Lázaro, Pablo Carbonell

Tackling climate change challenges requires replacing current chemical industrial processes through the rational and sustainable use of biodiversity resources. To that end, production routes to key bio-based chemicals for the bioeconomy have been identified. However, their production still remains inefficient in terms …

es (code pays fourni par la source)

Sensbio: an online server for biosensor design

Jonathan Tellechea‐Luzardo, Hèctor Martín Lázaro, Raúl Moreno López, Pablo Carbonell

Allosteric transcription factor (aTF) based biosensors can be used to engineer genetic circuits for a wide range of applications. The literature and online databases contain hundreds of experimentally validated molecule-TF pairs; however, the knowledge is scattered and often incomplete. Additionally, compared to …

es (code pays fourni par la source)

Transcription factor-based biosensors for screening and dynamic regulation

Jonathan Tellechea‐Luzardo, Martin Tillmann Stiebritz, Pablo Carbonell

Advances in synthetic biology and genetic engineering are bringing into the spotlight a wide range of bio-based applications that demand better sensing and control of biological behaviours. Transcription factor (TF)-based biosensors are promising tools that can be used to detect several types …

es (code pays fourni par la source)