Liz Brown

Compartmental inspiratory genioglossus electromyographic activity in supine, awake individuals with and without obstructive sleep apnoea

Lauriane Jugé, Peter G.R. Burke, Jade Yeung, Fiona L Knapman et autres

Abstract Inspiratory‐related genioglossus EMG activity is crucial to maintain upper airway patency. However, whether this activity differs between the oblique (middle) and horizontal (base) compartments or if they vary in people with obstructive sleep apnoea (OSA) is unknown. Here, intramuscular electrodes were …

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Evaluating Obstructive Sleep Apnea Neuropathophysiology with 1H-MRS and Cerebral Small Vessel Disease Imaging

Christopher M. Bull, Kurt Lancaster, Peter G.R. Burke, Mark Butlin et autres

Motivation: 1H-MRS may be sensitive enough to detect neuropathological mechanisms of cerebral small vessel disease in obstructive sleep apnoea (OSA). Goal(s): To investigate the relationships between nocturnal blood pressure surges (caused by sleep disturbances) and hypoxic burden (due to recurring apnoeas) on …

P001 Sleep disturbance in patients with long-term neurological sequelae of COVID-19

Kwok-Cheung Lung, Liz Brown, Lynne E. Bilston, Lauriane Jugé et autres

Abstract Introduction Post COVID-19 neurological sequelae (popularly termed “Long COVID”), which include chronic sleep disruption and “brain fog” are widespread; however, studies have not yet comprehensively evaluated the concurrent effects of these disruptions of neurocognitive function and their relationship to sleep disturbance. …

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Inspiratory dilatory tongue movement, as measured with tagged MRI, and intramuscular neural drive in obstructive sleep apnoea patients

Lauriane Jugé, Angela Liao, Jade Yeung, Fiona L Knapman et autres

As measured by tagged MRI, inspiratory tongue dilatory movement might be useful to shed new light on mechanisms controlling upper airway dilation in obstructive sleep apnoea (OSA). Nine healthy controls and 37 untreated OSA patients underwent an upper airway MRI scan and …

Stepwise and Targeted Therapy to Treat Sleep Apnea: A Novel, Physiology-informed, Personalised Approach Using Oral Appliance Therapy Plus Combination Therapy in Incomplete Responders

Danny Joel Eckert, B Tong, Atqiya Aishah, Ganesh R. Naik et autres

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Middle Passages: Lessons in Racial Subjection at the Hampton Institute and Carlisle Indian Industrial School

Liz Brown

Abstract: This essay argues that the historically Black Hampton Institute (1868) and the Carlisle Indian Industrial School (1879) are crucial sites to investigate how US political, territorial, and economic conquest were sutured to the project of emancipation after the Civil War. Rather …

Regional associations between inspiratory tongue dilatory movement and genioglossus activity during wakefulness in people with obstructive sleep apnoea

Lauriane Jugé, Angela Liao, Jade Yeung, Fiona L Knapman et autres

Inspiratory tongue dilatory movement is believed to be mediated via changes in neural drive to genioglossus. However, this has not been studied during quiet breathing in humans. Therefore, this study investigated this relationship and its potential role in obstructive sleep apnoea (OSA). …

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O011 Exploring Nocturnal Blood Pressure Surges Relationships with Brain Health and Cognitive Function.

Christopher M. Bull, Tao Zhang, Patrick J. Burke, Mark Butlin et autres

Abstract Introduction Cerebral small vessel disease is a possible mechanism to explain the link between long-term incompletely treated obstructive sleep apnoea (OSA) and dementia. Recent evidence suggests nocturnal blood pressure (BP) surges triggered by OSA-related sympathetic hyperactivity could play a critical role. …

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Stepwise Add-On and Endotype-informed Targeted Combination Therapy to Treat Obstructive Sleep Apnea: A Proof-of-Concept Study

Atqiya Aishah, B Tong, Amal M Osman, Geoffrey Pitcher et autres

Abstract Rationale Oral appliance therapy (OAT) is an effective treatment for many people with obstructive sleep apnea (OSA). However, OSA pathogenesis is heterogeneous, and, in ∼50% of cases, OAT does not fully control OSA. Objectives This study aimed to control OSA in …

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Our experience in developing and operating the Airway Intervention Registry for Recurrent Respiratory Papillomatosis (AIR-RRP): national data collection

Andrew J. Sims, Kim Keltie, Emma Belilios, Julie Burn et autres

Recurrent respiratory papillomatosis (RRP) is characterised by benign wart-like growths in the respiratory tract caused by the human papillomavirus (HPV). These warts vary in size and grow quickly, causing voice changes and airway obstruction. Whilst the condition is rare, RRP is more …

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Educating Heroic Chief Executives: Integrating Legal Studies and Social Change

Liz Brown

The relationship between mandibular advancement, tongue movement, and treatment outcome in obstructive sleep apnea

Lauriane Jugé, Fiona L Knapman, Peter Humburg, Peter G.R. Burke et autres

STUDY OBJECTIVES: To characterize how mandibular advancement enlarges the upper airway via posterior tongue advancement in people with obstructive sleep apnea (OSA) and whether this is associated with mandibular advancement splint (MAS) treatment outcome. METHODS: One-hundred and one untreated people with OSA …

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