Lauriane Jugé

The glioblastoma biomechanical landscape: A systematic review of magnetic resonance elastography (MRE) of brain tumors and healthy brain

Thuvarahan Jegathees, Lauriane Jugé, Eric K.C. Hau, Lynne E. Bilston et autres

Diagnosis of a glioblastoma (GBM) brain tumor is associated with very poor prognosis. Currently, few preclinical models used to identify new therapies address the soft brain tissue environment and GBM mechanoresponses, which are implicated in disease progression. Understanding the GBM biomechanical landscape …

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Compartmental inspiratory genioglossus electromyographic activity in supine, awake individuals with and without obstructive sleep apnoea

Lauriane Jugé, Peter G.R. Burke, Jade Yeung, Fiona L Knapman et autres

Abstract Inspiratory‐related genioglossus EMG activity is crucial to maintain upper airway patency. However, whether this activity differs between the oblique (middle) and horizontal (base) compartments or if they vary in people with obstructive sleep apnoea (OSA) is unknown. Here, intramuscular electrodes were …

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How mandibular and hyoid morphology alters tongue muscle architecture in healthy adults: An anatomical atlas and statistical shape model of the tongue

Robert A. Lloyd, Eranda Dissanayake, Lauriane Jugé, Bart Bolsterlee et autres

The tongue is a muscular hydrostat whose complex fibre architecture enables its diverse functions in swallowing, speech, and breathing. Current understanding of the tongue's structure is largely based on ex vivo dissections, which are not directly linked to function. This study aimed …

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Evaluating Obstructive Sleep Apnea Neuropathophysiology with 1H-MRS and Cerebral Small Vessel Disease Imaging

Christopher M. Bull, Kurt Lancaster, Peter G.R. Burke, Mark Butlin et autres

Motivation: 1H-MRS may be sensitive enough to detect neuropathological mechanisms of cerebral small vessel disease in obstructive sleep apnoea (OSA). Goal(s): To investigate the relationships between nocturnal blood pressure surges (caused by sleep disturbances) and hypoxic burden (due to recurring apnoeas) on …

O050 Regional electromyographic activity in genioglossus during quiet breathing in supine, awake individuals with and without sleep apnoea

Jade Yeung, Erik Brown, Patrick J. Burke, Lauriane Jugé et autres

Abstract Introduction Inspiratory-related genioglossus electromyography (EMG) activity is crucial to maintain upper airway patency during inspiration. Recent findings suggest variations in anterior/posterior genioglossus multiunit EMG activation during awake supine quiet breathing in healthy adults. However, whether such differences extend to EMG across …

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O048 Ultrasound evaluation of the pterygomandibular raphe in Obstructive Sleep Apnoea

Ediz Necati, Lauriane Jugé, Lynne E. Bilston, Erik Brown

Abstract Introduction The pterygomandibular raphe (PMR) is an aponeurotic junction in the lateral upper airway soft tissue that may be an anatomical marker to predict mandibular advancement splint (MAS) treatment success (Brown et al. 2021). We evaluated the feasibility of a novel …

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P001 Sleep disturbance in patients with long-term neurological sequelae of COVID-19

Kwok-Cheung Lung, Liz Brown, Lynne E. Bilston, Lauriane Jugé et autres

Abstract Introduction Post COVID-19 neurological sequelae (popularly termed “Long COVID”), which include chronic sleep disruption and “brain fog” are widespread; however, studies have not yet comprehensively evaluated the concurrent effects of these disruptions of neurocognitive function and their relationship to sleep disturbance. …

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Inspiratory dilatory tongue movement, as measured with tagged MRI, and intramuscular neural drive in obstructive sleep apnoea patients

Lauriane Jugé, Angela Liao, Jade Yeung, Fiona L Knapman et autres

As measured by tagged MRI, inspiratory tongue dilatory movement might be useful to shed new light on mechanisms controlling upper airway dilation in obstructive sleep apnoea (OSA). Nine healthy controls and 37 untreated OSA patients underwent an upper airway MRI scan and …

Regional associations between inspiratory tongue dilatory movement and genioglossus activity during wakefulness in people with obstructive sleep apnoea

Lauriane Jugé, Angela Liao, Jade Yeung, Fiona L Knapman et autres

Inspiratory tongue dilatory movement is believed to be mediated via changes in neural drive to genioglossus. However, this has not been studied during quiet breathing in humans. Therefore, this study investigated this relationship and its potential role in obstructive sleep apnoea (OSA). …

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O011 Exploring Nocturnal Blood Pressure Surges Relationships with Brain Health and Cognitive Function.

Christopher M. Bull, Tao Zhang, Patrick J. Burke, Mark Butlin et autres

Abstract Introduction Cerebral small vessel disease is a possible mechanism to explain the link between long-term incompletely treated obstructive sleep apnoea (OSA) and dementia. Recent evidence suggests nocturnal blood pressure (BP) surges triggered by OSA-related sympathetic hyperactivity could play a critical role. …

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O043 Investigating Upper-Airway Mechanics with Computational Tongue Models

Rhodri S. Lloyd, Lauriane Jugé, Lynne E. Bilston

Abstract With the use of computational models of the oral cavity, we aim to understand how changes in the morphology of the oral cavity and changes the stiffness of the tongue affect the movement of the posterior surface of the tongue. Anatomical …

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The combined use of MEGA- editing and asymmetric-PRESS methods improve the precision of cerebral lactate detection in healthy adults

Lauriane Jugé, Iain K. Ball, Caroline Rae

Here, we combined two 1H-MRS methods that have shown utility for detecting lactate in the brain, MEGA- editing and use of an asymmetric-PRESS and compared this approach (MEGA-APRESS) with MEGA-PRESS and A-PRESS in phantoms and eight individuals. MEGA-APRESS showed improved precision compared …