Bruno T. Roseguini

Pre-activation Using Intermittent Hypoxia: Muscle Oxygenation, Blood Lactate, And 400 M Crawl Swimming Performance

Lara S. Araujo, Marcelo Papoti, Bruno T. Roseguini, Daniel M. Hirai et autres

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Does a pharmacologically driven elevation in cerebral blood flow modulate cognition during combined hypoxic and thermal stress?

Eloisa Herrera-Ospina, Ernesto Ramirez-Jr., Rachel Bailey, Samuel T Stiles et autres

Acetazolamide increases cerebral blood flow (CBF), but whether this perfusion "reserve" protects executive function during combined hypoxic and thermal stress is unknown. We tested cognition during normothermia, hypoxia, hyperthermia, and combined stress after acetazolamide or placebo in a randomized, double-blind crossover design. …

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Near-infrared spectroscopy assessment of plantar forefoot reactive hyperemia in type 2 diabetes and peripheral artery disease

Emily Chan, Josi Gallo, Allison Miller, G Chen et autres

Foot complications, including sensory and motor impairments and ulcerations, are common in individuals with type 2 diabetes (T2D) and peripheral artery disease (PAD). These manifestations may arise partly from disturbances in microvascular function within the skin, subcutaneous tissue, and skeletal muscle of …

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HOTFOOT: Acute Effects of Combined Foot Heating and Pneumatic Compression in Type 2 Diabetes: a Preliminary Report

Carolyn Bakx, Bruno T. Roseguini

Background and Hypothesis: Despite over 1.2 million annual U.S. Type 2 Diabetic (T2D) diagnoses, effective therapies for diabetic foot complications remain limited. We hypothesized that a device combining pneumatic compression and localized heating could increase leg blood flow and foot oxygenation in …

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Turning up the gain without resistance: uncoupling of sympathetic transduction and vascular conductance following exercise

Eloisa Herrera-Ospina, Bruno T. Roseguini

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Feasibility of unsupervised, home-based leg heat therapy in older adults: a pilot, sham-controlled trial

Bohyun Ro, Luiza G. Castanhas, Fiona Crenshaw, Paul Swift et autres

This pilot trial demonstrates the feasibility of unsupervised, home-based leg heat therapy using water-circulating trousers in older adults. High adherence, minimal adverse events, and promising improvements in walking endurance support its potential as a scalable intervention for mobility preservation in aging. Findings …

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Noradrenergic regulation of skeletal muscle oxygen pressures: Impact of heart failure with preserved ejection fraction and heat therapy

Edward T. N. Calvo, Jacob M. Pontorno, B. Zeidler, Taciane Maria Melges Pejon et autres

Abstract Attenuation of sympathetic vasoconstriction during exercise (functional sympatholysis) contributes to skeletal muscle oxygen delivery–utilization matching. However, the extent to which muscle contractions impact noradrenergic regulation of interstitial oxygen pressures (; the driving force for blood–myocyte oxygen flux) is unknown. We tested …

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Effects of heat therapy on exercise tolerance in a rat model of heart failure with preserved ejection fraction

Michael D. Belbis, Bohyun Ro, Luke E. Schepers, Kun Ho Kim et autres

This is the first evaluation of the effects of heat therapy (HT) in heart failure with preserved ejection fraction (HFpEF). HT elicited multiple central and peripheral adaptations that impacted positively exercise tolerance in a preclinical model of HFpEF. HT adaptations included improvements …

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Feasibility of unsupervised home-based leg heat therapy in older adults: a pilot sham-controlled trial

Bohyun Ro, Luiza G. Castanhas, Fiona Crenshaw, Paul Swift et autres

The progressive decline in lower-extremity functioning with advancing age curtails independence and is a strong predictor of disability, hospitalizations, and mortality. Structured exercise is the cornerstone for improving functional capacity, but many older adults face barriers to regular physical activity. Accumulating evidence …

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Heat Therapy Does Not Restore Functional Sympatholysis Impairments in HFpEF Rodents

Edward T. N. Calvo, Jacob M. Pontorno, Michael D. Belbis, Bruno T. Roseguini et autres

Attenuation of sympathetic vasoconstriction during exercise (i.e., functional sympatholysis) plays a key role in the regulation of arterial blood pressure, peripheral O 2 delivery, and exercise tolerance. During skeletal muscle contractions, functional sympatholysis constrains the fall in interstitial oxygen pressures (PO 2 …

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Effects of acute selective cyclooxygenase‐2 inhibition on skeletal muscle microvascular oxygenation and exercise tolerance

Michael D. Belbis, Michael J. Holmes, Joseph D. Yao, Christopher W. Kinnick et autres

Abstract The cyclooxygenase (COX) pathway regulates vascular tone and, therefore, local O 2 delivery‐utilization matching. The two main isoforms, COX‐1 and COX‐2, may promote opposing effects on contracting muscle O 2 transport in health by inducing vasoconstriction and vasodilatation, respectively. Whether COX‐2 …

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Development and feasibility testing of a new device for home-based leg heat therapy in patients with lower extremity peripheral artery disease

Bohyun Ro, John C. H. Spence, Paul A. Spence, Christian Buckley et autres

People with symptomatic lower extremity peripheral artery disease (PAD) suffer from severe leg pain, walking impairment, and reduced quality of life, but few effective treatments are available. Emerging evidence suggests that regular heat therapy (HT) may improve cardiovascular and physical function in …

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