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Arturo Sosa, Michael D. Belbis, Michael J. Holmes, Keith Screen et autres
us, gb (code pays fourni par la source)
Vishakha Dey, Michael J. Holmes, Sandeep Srivastava, Emma H. Wilson et autres
ABSTRACT Toxoplasma gondii is a protozoan parasite that causes persistent infection in warm-blooded vertebrates by undergoing differentiation from a replicative stage (tachyzoites) to a latent encysted stage (bradyzoites). Stage differentiation is critical for transmission and pathogenesis and relies on gene regulation driven …
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Michael D. Belbis, Michael J. Holmes, Joseph D. Yao, Christopher W. Kinnick et autres
Abstract The cyclooxygenase (COX) pathway regulates vascular tone and, therefore, local O 2 delivery‐utilization matching. The two main isoforms, COX‐1 and COX‐2, may promote opposing effects on contracting muscle O 2 transport in health by inducing vasoconstriction and vasodilatation, respectively. Whether COX‐2 …
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Vishakha Dey, Michael J. Holmes, Sandeep Srivastava, Emma H. Wilson et autres
ABSTRACT Toxoplasma gondii is a protozoan parasite that causes persistent infection in warm-blooded vertebrates by undergoing differentiation from a replicative stage (tachyzoites) to a latent encysted stage (bradyzoites). Stage differentiation is critical for transmission and pathogenesis and relies on gene regulation driven …
us (code pays fourni par la source)
Vishakha Dey, Michael J. Holmes, Matheus Silva e Bastos, Ronald C. Wek et autres
Translational control mechanisms modulate the microbial latency of eukaryotic pathogens, enabling them to evade immunity and drug treatments. The protozoan parasite Toxoplasma gondii persists in hosts by differentiating from proliferative tachyzoites to latent bradyzoites, which are housed inside tissue cysts. Transcriptional changes …
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Vishakha Dey, Michael J. Holmes, Matheus Silva e Bastos, Ronald C. Wek et autres
Abstract Translational control mechanisms modulate microbial latency of eukaryotic pathogens, enabling them to evade immunity and drug treatments. The protozoan parasite Toxoplasma gondii persists in hosts by differentiating from proliferative tachyzoites to latent bradyzoites, which are housed inside tissue cysts. Transcriptional changes …
us (code pays fourni par la source)
Feng‐Rong Wang, Michael J. Holmes, Hea Jin Hong, Pariyamon Thaprawat et autres
The parasite Toxoplasma gondii persists in its hosts by converting from replicating tachyzoites to latent bradyzoites housed in tissue cysts. The molecular mechanisms that mediate T. gondii differentiation remain poorly understood. Through a mutagenesis screen, we identified translation initiation factor eIF1.2 as …
us, it (code pays fourni par la source)
Michael J. Holmes, Matheus Silva e Bastos, Vishakha Dey, Vanessa Rossini Severo et autres
ABSTRACT The protozoan parasite Toxoplasma gondii causes serious opportunistic disease due to its ability to persist in patients as latent tissue cysts. The molecular mechanisms coordinating conversion between proliferative parasites (tachyzoites) and latent cysts (bradyzoites) are not fully understood. We previously showed …
us (code pays fourni par la source)
Feng‐Rong Wang, Michael J. Holmes, Hea Jin Hong, Pariyamon Thaprawat et autres
Abstracts The parasite Toxoplasma gondii persists in its hosts by converting from replicating tachyzoites to latent bradyzoites housed in tissue cysts. The molecular mechanisms that mediate T. gondii differentiation remain poorly understood. Through a mutagenesis screen, we identified translation initiation factor eIF1.2 …
us (code pays fourni par la source)
Michael J. Holmes, Matheus Silva e Bastos, Vishakha Dey, Vanessa Rossini Severo et autres
Abstract The protozoan parasite Toxoplasma gondii causes serious opportunistic disease due to its ability to persist in patients as latent tissue cysts. The molecular mechanisms coordinating conversion between proliferative parasites (tachyzoites) and dormant cysts (bradyzoites) are not fully understood. We previously showed …
us (code pays fourni par la source)
Sarah L. Sokol-Borrelli, Sarah M. Reilly, Michael J. Holmes, Stephanie B. Orchanian et autres
Identification of regulators of Toxoplasma gondii bradyzoite development and cyst formation is the most direct way to address the importance of parasite development in long-term persistence and reactivation of this parasite. Here we show that a T. gondii gene (named Regulator of …
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Sandeep Srivastava, Michael J. Holmes, Michael W. White, William J. Sullivan
Toxoplasma gondii is a parasite that undergoes its sexual stage exclusively in feline intestines, making cats a major source of transmission. A better understanding of the proteins controlling the parasite's life cycle stage transitions is needed for the development of new therapies …
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